Gender-Specific Differences in Fetal Cardiac Troponin T in Pregnancies Complicated by Placental Insufficiency

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author NOMURA, Roseli M. Y. FMUSP-HC
ORTIGOSA, Cristiane FMUSP-HC
FIORELLI, Lilian R.
LIAO, Adolfo W. FMUSP-HC
ZUGAIB, Marcelo FMUSP-HC
dc.date.issued 2011
dc.identifier.citation GENDER MEDICINE, v.8, n.3, p.202-208, 2011
dc.identifier.issn 1550-8579
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/23201
dc.description.abstract Background: Placental insufficiency and fetal growth restriction may lead to fetal hypoxia and acidemia, which result in fetal cardiac injury. Objective: The goal of this study was to compare the levels of fetal cardiac troponin T (cTnT) at birth and fetal Doppler parameters according to fetal gender in pregnancies complicated by placental insufficiency before 34 weeks' gestation. Methods: Between March 2007 and November 2010, singleton pregnancies with placental insufficiency characterized by abnormal umbilical artery Doppler results were prospectively studied. All the patients delivered by cesarean section, and Doppler examinations were performed up to 48 hours before birth. Immediately after delivery, umbilical artery blood samples were obtained for fetal cTnT measurements. Results: Fifty high-risk pregnant women met the study criteria. The study groups were as follows: group 1 consisted of 23 male fetuses (46%) and group 2 consisted of 27 female fetuses (54%). cTnT levels were significantly higher in the group of male fetuses (median, 0.14; range, 0.01-0.85) compared with the group of female fetuses (median, 0.05; range, 0.01-0.27) (P = 0.039). In the group of male fetuses, Doppler results of the ductus venosus assessment revealed values of pulsatility index for veins >= 1.0 in 15 male fetuses (65.2%) and 9 female fetuses (33.3%) (P = 0.032). Conclusions: Fetal gender was associated with cTnT level at birth in pregnancies complicated by placental insufficiency before 34 weeks' gestation, although the Doppler findings did not support gender differences. The fetal cardiac compromise and cardiac injury may be influenced by fetal gender, suggesting differences in the cardiovascular response to fetal hypoxia. (Gend Med. 2011;8:202-208) (C) 2011 Elsevier HS Journals, Inc. All rights reserved.
dc.language.iso eng
dc.publisher EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
dc.relation.ispartof Gender Medicine
dc.rights restrictedAccess
dc.subject gender and health; placental insufficiency; troponin T; ultrasonography/doppler
dc.subject.other gestational-age; preterm birth; sex; weight; term; flow; 1st-trimester; disease; growth
dc.title Gender-Specific Differences in Fetal Cardiac Troponin T in Pregnancies Complicated by Placental Insufficiency
dc.type article
dc.rights.holder Copyright EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
dc.description.group LIM/57
dc.identifier.doi 10.1016/j.genm.2011.05.001
dc.identifier.pmid 21664586
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author NOMURA, Roseli M. Y.:FM:MOG
hcfmusp.author ORTIGOSA, Cristiane:FM:
hcfmusp.author LIAO, Adolfo W.:FM:MOG
hcfmusp.author ZUGAIB, Marcelo:FM:MOG
hcfmusp.author.external · FIORELLI, Lilian R.:Univ Sao Paulo, Sch Med, Dept Obstet & Gynecol, BR-05403000 Sao Paulo, Brazil
hcfmusp.origem.id 2-s2.0-79958706906
hcfmusp.origem.id WOS:000292439800005
hcfmusp.publisher.city BRIDGEWATER
hcfmusp.publisher.country USA
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dc.description.index PubMed
hcfmusp.citation.scopus 3
hcfmusp.affiliation.country Brasil
hcfmusp.scopus.lastupdate 2021-08-27


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