Comparison between the effects of platelet-rich plasma and bone marrow concentrate on defect consolidation in the rabbit tibia

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author BATISTA, Marco Antonio FMUSP-HC
LEIVAS, Tomaz Puga FMUSP-HC
RODRIGUES, Consuelo Junqueira FMUSP-HC
ARENAS, Gessica Cantadori Funes
BELITARDO, Donizeti Rodrigues
GUARNIERO, Roberto FMUSP-HC
dc.date.issued 2011
dc.identifier.citation CLINICS, v.66, n.10, p.1787-1792, 2011
dc.identifier.issn 1807-5932
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/23256
dc.description.abstract OBJECTIVE: To perform a comparative analysis of the effects of platelet-rich plasma and centrifuged bone marrow aspirate on the induction of bone healing in rabbits. METHOD: Twenty adult, male New Zealand rabbits were randomly separated into two equal groups, and surgery was performed to create a bone defect (a cortical orifice 3.3 mm in diameter) in the proximal metaphysis of each rabbit's right tibia. In the first group, platelet-rich plasma was implanted in combination with beta-tricalcium phosphate (platelet-rich plasma group), and in the second group, centrifuged bone marrow in combination with beta-tricalcium phosphate (centrifuged bone marrow group) was implanted. After a period of four weeks, the animals were euthanized, and the tibias were evaluated using digital radiography, computed tomography, and histomorphometry. RESULTS: Seven samples from each group were evaluated. The radiographic evaluation confirmed the absence of fractures in the postoperative limb and identified whether bone consolidation had occurred. The tomographic evaluation revealed a greater amount of consolidation and the formation of a greater cortical bone thickness in the platelet-rich plasma group. The histomorphometry revealed a greater bone density in the platelet-rich plasma group compared with the centrifuged bone marrow group. CONCLUSION: After four weeks, the platelet-rich plasma promoted a greater amount of bone consolidation than the bone marrow aspirate concentrate.
dc.language.iso eng
dc.publisher HOSPITAL CLINICAS, UNIV SAO PAULO
dc.relation.ispartof Clinics
dc.rights openAccess
dc.subject Bone substitutes; Fracture healing; Radiology; Tomography; Histology
dc.subject.other growth-factors; fractures; surgery; biology; grafts; repair
dc.title Comparison between the effects of platelet-rich plasma and bone marrow concentrate on defect consolidation in the rabbit tibia
dc.type article
dc.rights.holder Copyright HOSPITAL CLINICAS, UNIV SAO PAULO
dc.description.group LIM/41
dc.identifier.doi 10.1590/S1807-593220110007000018
dc.identifier.pmid 22012052
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author BATISTA, Marco Antonio:HC:LIM/41
hcfmusp.author LEIVAS, Tomaz Puga:HC:IOT
hcfmusp.author RODRIGUES, Consuelo Junqueira:FM:MOT
hcfmusp.author GUARNIERO, Roberto:FM:MOT
hcfmusp.author.external · ARENAS, Gessica Cantadori Funes:Univ Sao Paulo, Fac Med, Sao Paulo, Brazil
· BELITARDO, Donizeti Rodrigues:Univ Estadual Londrina, Clin Cirurgica, Londrina, PR, Brazil
hcfmusp.origem.id 2-s2.0-80054771646
hcfmusp.origem.id WOS:000296015500018
hcfmusp.publisher.city SAO PAULO
hcfmusp.publisher.country BRAZIL
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dc.description.index MEDLINE
hcfmusp.citation.scopus 18
hcfmusp.affiliation.country Brasil
hcfmusp.scopus.lastupdate 2021-07-14


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