Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/23284
Title: P-Glycoprotein Expression, Tumor Weight, Age, and Relapse in Patients with Stage I and II Favorable-Histology Wilms' Tumor
Authors: TEIXEIRA, Roberto Augusto PlazaODONE-FILHO, VicenteCAMARGO, Beatriz deZERBINI, Maria ClaudiaFILLIPI, RenneALENCAR, ArlaineCRISTOFANI, Lilian
Citation: PEDIATRIC HEMATOLOGY AND ONCOLOGY, v.28, n.3, p.194-202, 2011
Abstract: Fifteen percent of patients with Wilms'' tumor (WT) experience relapse. It has been suggested that weight and age may affect the chances of relapse. Few studies have investigated the role, if any, between P-glycoprotein (P-gp) and relapse. The authors assessed the prognostic value of tumor weight and age at diagnosis and asked whether some other potential biological markers, specifically P-gp protein expression, had a prognostic value in favorable-histology WT. No association between age and relapse could be found. Patients with tumor weight >= a parts per thousand yen550 g were 6 times more likely to relapse, whereas P-gp expression was positive in 18/40 (45%%) of the patients, of which 10/12 (83.3%%) relapsed and 8/28 (28.6%%) did not. Further studies are necessary to elucidate whether or not P-gp is related to relapse in patients with histologically favorable Wilms'' tumor. If confirmed, the protein may be used in the future as a target for new drugs and treatments for this group of patients.</.
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Artigos e Materiais de Revistas Científicas - FM/MPE
Departamento de Pediatria - FM/MPE

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - HC/ICr
Instituto da Criança - HC/ICr

Artigos e Materiais de Revistas Científicas - LIM/14
LIM/14 - Laboratório de Investigação em Patologia Hepática

Artigos e Materiais de Revistas Científicas - LIM/36
LIM/36 - Laboratório de Pediatria Clínica


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