Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/23333
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorSZYMANSKA, K.-
dc.contributor.authorHUNG, R. J.-
dc.contributor.authorWUENSCH-FILHO, V.-
dc.contributor.authorELUF-NETO, J.-
dc.contributor.authorCURADO, M. P.-
dc.contributor.authorKOIFMAN, S.-
dc.contributor.authorMATOS, E.-
dc.contributor.authorMENEZES, A.-
dc.contributor.authorFERNANDEZ, L.-
dc.contributor.authorDAUDT, A. W.-
dc.contributor.authorBOFFETTA, P.-
dc.contributor.authorBRENNAN, P.-
dc.date.accessioned2017-11-27T16:33:58Z-
dc.date.available2017-11-27T16:33:58Z-
dc.date.issued2011-
dc.identifier.citationCANCER CAUSES & CONTROL, v.22, n.7, p.1037-1046, 2011-
dc.identifier.issn0957-5243-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/23333-
dc.description.abstractCancers of the upper aerodigestive tract (UADT; including oral cavity, pharynx, larynx and oesophagus) have high incidence rates all over the world, and they are especially frequent in some parts of Latin America. However, the data on the role of the major risk factors in these areas are still limited. We have evaluated the role of alcohol and tobacco consumption, based on 2,252 upper aerodigestive squamous-cell carcinoma cases and 1,707 controls from seven centres in Brazil, Argentina, and Cuba. We show that alcohol drinkers have a risk of UADT cancers that is up to five times higher than that of never-drinkers. A very strong effect of aperitifs and spirits as compared to other alcohol types was observed, with the ORs reaching 12.76 (CI 5.37-30.32) for oesophagus. Tobacco smokers were up to six times more likely to develop aerodigestive cancers than never-smokers, with the ORs reaching 11.14 (7.72-16.08) among current smokers for hypopharynx and larynx cancer. There was a trend for a decrease in risk after quitting alcohol drinking or tobacco smoking for all sites. The interactive effect of alcohol and tobacco was more than multiplicative. In this study, 65% of all UADT cases were attributable to a combined effect of alcohol and tobacco use. In this largest study on UADT cancer in Latin America, we have shown for the first time that a prevailing majority of UADT cancer cases is due to a combined effect of alcohol and tobacco use and could be prevented by quitting the use of either of these two agents.-
dc.description.sponsorshipEuropean Commission [IC18-CT97-0222]-
dc.description.sponsorshipFondo para la Investigacion Cientifica y Tecnologica (Argentina)-
dc.description.sponsorshipFundacao de Amparo a Pesquisa no Estado de Sao Paulo [01/01768-2]-
dc.description.sponsorshipInternational Agency for Research on Cancer-
dc.language.isoeng-
dc.publisherSPRINGER-
dc.relation.ispartofCancer Causes & Control-
dc.rightsrestrictedAccess-
dc.subjectUpper aerodigestive tract-
dc.subjectSouth America-
dc.subjectTobacco-
dc.subjectAlcohol-
dc.subjectCancer-
dc.subject.otheresophageal cancer-
dc.subject.othermate drinking-
dc.subject.otheruruguay-
dc.subject.otherbrazil-
dc.subject.othersmoking-
dc.subject.otherbeverage-
dc.subject.othersmokers-
dc.subject.othereurope-
dc.subject.otherdiet-
dc.titleAlcohol and tobacco, and the risk of cancers of the upper aerodigestive tract in Latin America: a case-control study-
dc.typearticle-
dc.rights.holderCopyright SPRINGER-
dc.identifier.doi10.1007/s10552-011-9779-7-
dc.identifier.pmid21607590-
dc.subject.wosOncology-
dc.subject.wosPublic, Environmental & Occupational Health-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalSZYMANSKA, K.:Int Agcy Res Canc, F-69008 Lyon, France-
hcfmusp.author.externalHUNG, R. J.:Int Agcy Res Canc, F-69008 Lyon, France; Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada-
hcfmusp.author.externalWUENSCH-FILHO, V.:Univ Sao Paulo, Sao Paulo, Brazil-
hcfmusp.author.externalCURADO, M. P.:Int Agcy Res Canc, F-69008 Lyon, France; Goiania Canc Registry, Goiania, Go, Brazil-
hcfmusp.author.externalKOIFMAN, S.:Sch Publ Hlth, Rio De Janeiro, Brazil-
hcfmusp.author.externalMATOS, E.:Univ Buenos Aires, Buenos Aires, DF, Argentina-
hcfmusp.author.externalMENEZES, A.:Univ Fed Pelotas, Pelotas, Brazil-
hcfmusp.author.externalFERNANDEZ, L.:Inst Oncol & Radiobiol, Havana, Cuba-
hcfmusp.author.externalDAUDT, A. W.:Clin Hosp Porto Alegre, Porto Alegre, RS, Brazil-
hcfmusp.author.externalBOFFETTA, P.:Int Agcy Res Canc, F-69008 Lyon, France-
hcfmusp.author.externalBRENNAN, P.:Int Agcy Res Canc, F-69008 Lyon, France-
hcfmusp.description.beginpage1037-
hcfmusp.description.endpage1046-
hcfmusp.description.issue7-
hcfmusp.description.volume22-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-79960236536-
hcfmusp.origem.idWOS:000291742700010-
hcfmusp.publisher.cityDORDRECHT-
hcfmusp.publisher.countryNETHERLANDS-
hcfmusp.relation.referenceFRANCO EL, 1989, INT J CANCER, V43, P992, DOI 10.1002/ijc.2910430607-
hcfmusp.relation.referenceHashibe M, 2007, INT J CANCER, V120, P1518, DOI 10.1002/ijc.22507-
hcfmusp.relation.referenceSchlecht NF, 1999, AM J EPIDEMIOL, V150, P1129-
hcfmusp.relation.reference[Anonymous], 2000, INT CLASSIFICATION D-
hcfmusp.relation.referenceRibeiro KB, 2011, INT J EPIDEMIOL, V40, P489, DOI 10.1093/ije/dyq249-
hcfmusp.relation.referenceCastellsague X, 1999, INT J CANCER, V82, P657, DOI 10.1002/(SICI)1097-0215(19990827)82:5<657::AID-IJC7>3.0.CO;2-C-
hcfmusp.relation.reference[Anonymous], 2004, IARC MONOGRAPHS EVAL-
hcfmusp.relation.referenceBosetti C, 2002, BRIT J CANCER, V87, P516, DOI 10.1038/sj.bjc.6600469-
hcfmusp.relation.referenceHanley JA, 2001, J EPIDEMIOL COMMUN H, V55, P508, DOI 10.1136/jech.55.7.508-
hcfmusp.relation.referenceHashibe M, 2007, AM J EPIDEMIOL, V165, P814, DOI 10.1093/aje/kwk066-
hcfmusp.relation.referenceVineis P, 2004, JNCI-J NATL CANCER I, V96, P99, DOI 10.1093/jnci/djh014-
hcfmusp.relation.referenceCASTELLETTO R, 1994, CANCER EPIDEM BIOMAR, V3, P557-
hcfmusp.relation.referenceGarrote LF, 2001, BRIT J CANCER, V85, P46, DOI 10.1054/bjoc.2000.1825-
hcfmusp.relation.referenceDESTEFANI E, 1988, REV EPIDEMIOL SANTE, V36, P389-
hcfmusp.relation.referenceDESTEFANI E, 1990, CANCER RES, V50, P426-
hcfmusp.relation.referenceDESTEFANI E, 1987, CANCER, V60, P3087, DOI 10.1002/1097-0142(19871215)60:12<3087::AID-CNCR2820601238>3.0.CO;2-6-
hcfmusp.relation.referenceFERLAY J, 2002, GLOBOCAN-
hcfmusp.relation.referenceFioretti F, 1999, ORAL ONCOL, V35, P375, DOI 10.1016/S1368-8375(98)00125-0-
hcfmusp.relation.referenceOREGGIA F, 1991, CANCER, V67, P180, DOI 10.1002/1097-0142(19910101)67:1<180::AID-CNCR2820670130>3.0.CO;2-R-
hcfmusp.relation.referenceSchlect NF, 1999, EPIDEMIOLOGY, V10, P412, DOI 10.1097/00001648-199907000-00012-
hcfmusp.relation.referenceSchlecht NF, 2001, CANCER CAUSE CONTROL, V12, P579, DOI 10.1023/A:1011226520220-
hcfmusp.relation.referenceVASSALLO A, 1985, J NATL CANCER I, V75, P1005-
hcfmusp.relation.referenceZambon P, 2000, INT J CANCER, V86, P144, DOI 10.1002/(SICI)1097-0215(20000401)86:1<144::AID-IJC23>3.0.CO;2-B-
hcfmusp.relation.reference1988, IARC MONOGRAPHS EVAL-
hcfmusp.relation.reference2008, IARC MONOGRAPHS EVAL-
dc.description.indexMEDLINE-
hcfmusp.citation.scopus45-
hcfmusp.scopus.lastupdate2022-09-30-
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