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https://observatorio.fm.usp.br/handle/OPI/23398
Title: | Increased Brain Membrane Fluidity in Schizophrenia |
Authors: | ECKERT, G. P.; SCHAEFFER, E. L.; SCHMITT, A.; MARAS, A.; GATTAZ, W. F. |
Citation: | PHARMACOPSYCHIATRY, v.44, n.4, p.161-163, 2011 |
Abstract: | Recent findings showing significant correlations between phospholipase A2 (PLA2) activity and structural changes in schizophrenic brains contribute to the membrane hypothesis of schizophrenia, which was hampered because a clean functional link between elevated PLA2 activity and brain structure was missing (Neuroimage, 2010; 52: 1314-1327). We measured membrane fluidity parameters and found that brain membranes isolated from the prefrontal cortex of schizophrenic patients showed significantly increased flexibility of fatty acid chains. Our findings support a possible link between elevated PLA2 activity in cortical areas of schizophrenic patients and subsequent alterations of the biophysical parameters of neuronal membranes leading to structural changes in these areas. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPS Artigos e Materiais de Revistas Científicas - LIM/27 |
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