HER2 Testing in Breast Carcinoma Very Low Concordance Rate Between Reference and Local Laboratories in Brazil

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author WLUDARSKI, Sheila Cristina Lordelo FMUSP-HC
LOPES, Lisandro Ferreira
SILVA, Tacio R. Berto e
WEISS, Lawrence M.
dc.date.issued 2011
dc.identifier.citation APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, v.19, n.2, p.112-118, 2011
dc.identifier.issn 1062-3345
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/23517
dc.description.abstract Breast cancer accounts for approximately one quarter of all cancers in females. HER2 gene amplification or HER2 protein overexpression, detected in about 20% of breast carcinomas, predicts a more aggressive clinical course and determines eligibility for targeted therapy with trastuzumab. HER2 testing has become an essential part of the clinical evaluation of all breast carcinoma patients, and accurate HER2 results are critical in identifying patients who may be benefited from targeted therapy. This study investigated the concordance in the results of HER2 immunohistochemistry assays performed in 500 invasive breast carcinomas between a reference laboratory and 149 local laboratories from all geographic regions of Brazil. Our results showed an overall poor concordance (171 of 500 cases, 34.2%) regarding HER2 results between local and reference laboratories, which may be related to the low-volume load of HER2 assays, inexperience with HER2 scoring system, and/or technical issues related to immunohistochemistry in local laboratories. Standardization of HER2 testing with rigorous quality control measures by local laboratories is highly recommended to avoid erroneous treatment of breast cancer patients.
dc.language.iso eng
dc.relation.ispartof Applied Immunohistochemistry & Molecular Morphology
dc.rights restrictedAccess
dc.subject Brazil; HER2; immunohistochemistry; local laboratory; reference laboratory
dc.subject.other her-2/neu gene amplification; rabbit monoclonal-antibody; situ hybridization fish; of-american-pathologists; archival tissue samples; cancer; immunohistochemistry; trastuzumab; oncogene; ihc
dc.title HER2 Testing in Breast Carcinoma Very Low Concordance Rate Between Reference and Local Laboratories in Brazil
dc.type article
dc.rights.holder Copyright LIPPINCOTT WILLIAMS & WILKINS
dc.description.group LIM/14
dc.identifier.doi 10.1097/PAI.0b013e3181f0b044
dc.identifier.pmid 20930616
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author WLUDARSKI, Sheila Cristina Lordelo:FM:
hcfmusp.author CARVALHO, Filomena M.:FM:MPT
hcfmusp.author BACCHI, Carlos E.:FM:
hcfmusp.author.external · LOPES, Lisandro Ferreira:Consultoria Patol, BR-18602010 Botucatu, SP, Brazil
· SILVA, Tacio R. Berto e:Consultoria Patol, BR-18602010 Botucatu, SP, Brazil
· WEISS, Lawrence M.:City Hope Natl Med Ctr, Div Pathol, Duarte, CA 91010 USA
hcfmusp.origem.id 2-s2.0-79951942570
hcfmusp.origem.id WOS:000287190000005
hcfmusp.publisher.city PHILADELPHIA
hcfmusp.publisher.country USA
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dc.description.index WoS
hcfmusp.citation.scopus 14
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Estados Unidos
hcfmusp.scopus.lastupdate 2021-08-27

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