Evaluation of the Combination of Cytology and Hybrid Capture to Safely Predict the High-Grade Lesion Status of Patients Treated with Conization with Large Loop Excision of the Transformation Zone

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author RONCAGLIA, Maria Teresa FMUSP-HC
MOTTA, Eduardo Vieira da FMUSP-HC
ALVES, Venancio Avancini Ferreira FMUSP-HC
dc.date.issued 2011
dc.identifier.citation ACTA CYTOLOGICA, v.55, n.5, p.421-425, 2011
dc.identifier.issn 0001-5547
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/23531
dc.description.abstract Objectives: This study aimed to verify whether human papillomavirus (HPV) testing after conization treatment has some potential usefulness for predicting patients' outcome. Study Design: One hundred and twenty women were treated for HSIL by conization with large loop excision of the transformation zone (LLETZ). Cytology, colposcopy-guided biopsy, and hybrid capture 2 (HC2) HPV DNA tests were performed before the surgical procedure and every 6 months for 2 years at follow-up. Results: More than 90% of the patients tested positive for high-risk HPV prior to the surgical intervention. Six months after the cervical conization, 74.75% of the patients tested negative for high-risk HPV DNA, and 19.41% were positive. Of the women who were HC2 negative, 72 showed normal cytological smears, 3 ASC-US, 2 LSIL, and 1 HSIL. Of those who were HC2 positive, 8 showed normal smears, 2 ASC-US, 2 ASC-H, 5 LSIL, and 1 case had HSIL, AGC, and squamous cells invasive carcinoma. Clinically, the HSIL case with a negative HPV test did not show any sign of high-grade lesions, and the clinical follow-up did not show residual lesions. Conclusions: Negative HPV tests correlated with freedom from high-grade disease after 2 years of postconization follow-up, which strongly suggests that negative HPV tests predict the absence of cervical disease.
dc.language.iso eng
dc.publisher KARGER
dc.relation.ispartof Acta Cytologica
dc.rights restrictedAccess
dc.subject Human papillomavirus; Hybrid capture; Conization; High-grade lesion
dc.subject.other cervical intraepithelial neoplasia; human-papillomavirus; women; cancer; hpv; persistence; lletz
dc.title Evaluation of the Combination of Cytology and Hybrid Capture to Safely Predict the High-Grade Lesion Status of Patients Treated with Conization with Large Loop Excision of the Transformation Zone
dc.type article
dc.rights.holder Copyright KARGER
dc.description.group LIM/14
dc.description.group LIM/03
dc.description.group LIM/58
dc.identifier.doi 10.1159/000330808
dc.identifier.pmid 21986168
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author RONCAGLIA, Maria Teresa:FM:
hcfmusp.author TACLA, Maricy:HC:ICHC
hcfmusp.author MOTTA, Eduardo Vieira da:HC:ICHC
hcfmusp.author CAIAFFA, Helio:HC:ICHC
hcfmusp.author AB'SABER, Alexandre:HC:ICHC
hcfmusp.author ALVES, Venancio Avancini Ferreira:FM:MPT
hcfmusp.author LONGATTO FILHO, Adhemar:HC:LIM/14
hcfmusp.author BARACAT, Edmund C.:FM:MOG
hcfmusp.origem.id WOS:000296242700005
hcfmusp.origem.id 2-s2.0-80155192497
hcfmusp.publisher.city BASEL
hcfmusp.publisher.country SWITZERLAND
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dc.description.index MEDLINE
hcfmusp.citation.scopus 4
hcfmusp.scopus.lastupdate 2021-08-27

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