Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/23625
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | SOUZA, Daniela Raguer Valadao de | - |
dc.contributor.author | SANABANI, Sabri Saeed | - |
dc.contributor.author | SOUZA, Ana Carolina Mamana Fernandes de | - |
dc.contributor.author | ODONE, Vicente Filho | - |
dc.contributor.author | EPELMAN, Sidnei | - |
dc.contributor.author | BENDIT, Israel | - |
dc.date.accessioned | 2017-11-27T16:38:25Z | - |
dc.date.available | 2017-11-27T16:38:25Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | PEDIATRIC BLOOD & CANCER, v.56, n.5, p.749-756, 2011 | - |
dc.identifier.issn | 1545-5009 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/23625 | - |
dc.description.abstract | Background. The aims of this study were to define the mRNA expression profiles of MYCN, DDX1, TrkA, and TrkC in biopsy tumor samples from 64 Brazilian patients with neuroblastomas of different risk stages and to correlate altered expression with prognostic values. Procedure. Patients were retrospectively classified into low- (n = 11), intermediate- (n = 18), and high-risk (n = 35) groups using standard criteria. The mRNA levels of the above genes were measured by quantitative real-time polymerase chain reaction. Univariate analyses were performed and survival curves were plotted by the Kaplan-Meier method. Results. Of the 64 patients, 53% were female and 62.5% were older than 18 months. The 5-year overall survival (OS) for the entire cohort was 40.3%, with inferior median OS in patients identified in the intermediate- and high-risk groups. A significant difference in OS with respect to TrkA mRNA expression was found for the high-risk group vs. either the low- or intermediate-risk groups (P < 0.01, log rank test). Within the intermediate-risk group, neuroblastoma patients with positive TrkA mRNA expression had better clinical outcomes than patients with no TrkA transcript expression (P = 0.004). Another difference in OS was only found between the intermediate- and high-risk groups (P < 0.027, log rank test). No significant correlation of mRNA expression and survival outcome could be detected for the MYCN, DDX1. Conclusions. Positive expression of TrkA mRNA may be a clinically useful addition to the current risk classification system, allowing the identification of NB tumors with favorable prognosis. Pediatr Blood Cancer 2011; 56: 749-756. (c) 2010 Wiley-Liss, Inc. | - |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [03/09696-6] | - |
dc.language.iso | eng | - |
dc.publisher | WILEY PERIODICALS, INC | - |
dc.relation.ispartof | Pediatric Blood & Cancer | - |
dc.rights | restrictedAccess | - |
dc.subject | gene expression | - |
dc.subject | neuroblastoma | - |
dc.subject | risk classification | - |
dc.subject.other | improved survival probability | - |
dc.subject.other | time quantitative pcr | - |
dc.subject.other | nerve growth-factor | - |
dc.subject.other | dead box gene | - |
dc.subject.other | n-myc | - |
dc.subject.other | amplified neuroblastoma | - |
dc.subject.other | international criteria | - |
dc.subject.other | nonamplified mycn | - |
dc.subject.other | neuro-blastoma | - |
dc.subject.other | stage iv | - |
dc.title | Prognostic Impact of MYCN, DDX1, TrkA, and TrkC Gene Transcripts Expression in Neuroblastoma | - |
dc.type | article | - |
dc.rights.holder | Copyright WILEY PERIODICALS, INC | - |
dc.identifier.doi | 10.1002/pbc.22823 | - |
dc.identifier.pmid | 21154590 | - |
dc.subject.wos | Oncology | - |
dc.subject.wos | Hematology | - |
dc.subject.wos | Pediatrics | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | EPELMAN, Sidnei:Hosp Santa Marcelina Sao Paulo, Sao Paulo, Brazil | - |
hcfmusp.description.beginpage | 749 | - |
hcfmusp.description.endpage | 756 | - |
hcfmusp.description.issue | 5 | - |
hcfmusp.description.volume | 56 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000288132100008 | - |
hcfmusp.origem.id | 2-s2.0-79952179097 | - |
hcfmusp.publisher.city | MALDEN | - |
hcfmusp.publisher.country | USA | - |
hcfmusp.relation.reference | Alaminos M, 2005, PEDIATR BLOOD CANCER, V45, P909, DOI 10.1002/pbc.20505 | - |
hcfmusp.relation.reference | LAVENIUS E, 1995, CELL GROWTH DIFFER, V6, P727 | - |
hcfmusp.relation.reference | Cohn SL, 2000, J CLIN ONCOL, V18, P3604 | - |
hcfmusp.relation.reference | LOOK AT, 1991, J CLIN ONCOL, V9, P581 | - |
hcfmusp.relation.reference | MANOHAR CF, 1995, GENE CHROMOSOME CANC, V14, P196, DOI 10.1002/gcc.2870140307 | - |
hcfmusp.relation.reference | SEEGER RC, 1985, NEW ENGL J MED, V313, P1111, DOI 10.1056/NEJM198510313131802 | - |
hcfmusp.relation.reference | Aoki T, 2009, MOL BIOL CELL, V20, P2639, DOI 10.1091/mbc.E08-11-1104 | - |
hcfmusp.relation.reference | MATSUSHIMA H, 1993, MOL CELL BIOL, V13, P7447 | - |
hcfmusp.relation.reference | De Preter K, 2002, MODERN PATHOL, V15, P159, DOI 10.1038/modpathol.3880508 | - |
hcfmusp.relation.reference | Fredlund E, 2008, P NATL ACAD SCI USA, V105, P14094, DOI 10.1073/pnas.0804455105 | - |
hcfmusp.relation.reference | SQUIRE JA, 1995, ONCOGENE, V10, P1417 | - |
hcfmusp.relation.reference | NAKAGAWARA A, 1993, NEW ENGL J MED, V328, P847, DOI 10.1056/NEJM199303253281205 | - |
hcfmusp.relation.reference | Weber A, 2004, J CLIN ONCOL, V22, P2681, DOI 10.1200/JCO.2004.07.192 | - |
hcfmusp.relation.reference | Kaneko S, 2007, J CANCER RES CLIN, V133, P185, DOI 10.1007/s00432-006-0156-y | - |
hcfmusp.relation.reference | Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262 | - |
hcfmusp.relation.reference | Oberthuer A, 2009, FUTURE ONCOL, V5, P625, DOI [10.2217/fon.09.41, 10.2217/FON.09.41] | - |
hcfmusp.relation.reference | Wei JS, 2004, CANCER RES, V64, P6883, DOI 10.1158/0008-5472.CAN-04-0695 | - |
hcfmusp.relation.reference | Maris JM, 2007, LANCET, V369, P2106, DOI 10.1016/S0140-6736(07)60983-0 | - |
hcfmusp.relation.reference | Schmidt ML, 2000, J CLIN ONCOL, V18, P1260 | - |
hcfmusp.relation.reference | BRODEUR GM, 1993, J CLIN ONCOL, V11, P1466 | - |
hcfmusp.relation.reference | Fulda S, 1999, ONCOGENE, V18, P1479, DOI 10.1038/sj.onc.1202435 | - |
hcfmusp.relation.reference | Alaminos M, 2003, CANCER RES, V63, P4538 | - |
hcfmusp.relation.reference | NAKAGAWARA A, 1994, MOL CELL BIOL, V14, P759 | - |
hcfmusp.relation.reference | DuBois SG, 1999, J PEDIAT HEMATOL ONC, V21, P181, DOI 10.1097/00043426-199905000-00005 | - |
hcfmusp.relation.reference | Shimada H, 1999, CANCER, V86, P364, DOI 10.1002/(SICI)1097-0142(19990715)86:2<364::AID-CNCR21>3.0.CO;2-7 | - |
hcfmusp.relation.reference | Peirce SK, 2009, ONCOL REP, V22, P1443, DOI 10.3892/or_00000586 | - |
hcfmusp.relation.reference | Schmidt ML, 2005, J CLIN ONCOL, V23, P6474, DOI 10.1200/JCO.2005.05.183 | - |
hcfmusp.relation.reference | BRODEUR GM, 1984, SCIENCE, V224, P1121, DOI 10.1126/science.6719137 | - |
hcfmusp.relation.reference | BRODEUR GM, 1995, EUR J CANCER, V31A, P505, DOI 10.1016/0959-8049(95)00040-P | - |
hcfmusp.relation.reference | BRODEUR GM, 1988, J CLIN ONCOL, V6, P1874 | - |
hcfmusp.relation.reference | Chan HSL, 1997, CLIN CANCER RES, V3, P1699 | - |
hcfmusp.relation.reference | Coelho MCM, 2008, PEDIATR SURG INT, V24, P1017, DOI 10.1007/s00383-008-2207-8 | - |
hcfmusp.relation.reference | De Preter K, 2005, J CLIN ONCOL, V23, P3168 | - |
hcfmusp.relation.reference | De Preter K, 2005, J CLIN ONCOL, V23, P3167, DOI 10.1200/JCO.2005.05.346 | - |
hcfmusp.relation.reference | Fulda S, 2000, MED PEDIATR ONCOL, V35, P582, DOI 10.1002/1096-911X(20001201)35:6<582::AID-MPO19>3.0.CO;2-2 | - |
hcfmusp.relation.reference | George RE, 1997, EUR J CANCER, V33, P2037, DOI 10.1016/S0959-8049(97)00206-2 | - |
hcfmusp.relation.reference | Lavoie JF, 2005, J BIOL CHEM, V280, P29199, DOI 10.1074/jbc.M502364200 | - |
hcfmusp.relation.reference | NAKAGAWARA A, 1992, CANCER RES, V52, P1364 | - |
hcfmusp.relation.reference | Nakagawara A, 2001, CANCER LETT, V169, P107, DOI 10.1016/S0304-3835(01)00530-4 | - |
hcfmusp.relation.reference | NAKAGAWARA A, 1990, CANCER RES, V50, P3043 | - |
hcfmusp.relation.reference | NEGRONI A, 1991, CELL GROWTH DIFFER, V2, P511 | - |
hcfmusp.relation.reference | NISEN PD, 1988, J NATL CANCER I, V80, P1633, DOI 10.1093/jnci/80.20.1633 | - |
hcfmusp.relation.reference | Oberthuer A, 2007, CANCER LETT, V250, P250, DOI 10.1016/j.canlet.2006.10.016 | - |
hcfmusp.relation.reference | Oberthuer A, 2006, J CLIN ONCOL, V24, P5070, DOI 10.1200/JCO.2006.06.1879 | - |
hcfmusp.relation.reference | Ohira M, 2005, CANCER CELL, V7, P337, DOI 10.1016/j.ccr.2005.03.019 | - |
hcfmusp.relation.reference | Ryden M, 1996, BRIT J CANCER, V74, P773, DOI 10.1038/bjc.1996.435 | - |
hcfmusp.relation.reference | SCHMIDT ML, 1994, CELL GROWTH DIFFER, V5, P171 | - |
hcfmusp.relation.reference | Schramm A, 2005, ONCOGENE, V24, P7902, DOI 10.1038/sj.onc.1208936 | - |
hcfmusp.relation.reference | Seeger R C, 1988, Prog Clin Biol Res, V271, P41 | - |
hcfmusp.relation.reference | SLAVC I, 1990, CANCER RES, V50, P1459 | - |
hcfmusp.relation.reference | Souza ACMF, 2009, BRAZ J MED BIOL RES, V42, P791, DOI 10.1590/S0100-879X2009000900004 | - |
hcfmusp.relation.reference | SUZUKI T, 1993, J NATL CANCER I, V85, P377, DOI 10.1093/jnci/85.5.377 | - |
hcfmusp.relation.reference | Tajiri T, 2007, J PEDIATR SURG, V42, P2046, DOI 10.1016/j.jpedsurg.2007.08.024 | - |
hcfmusp.relation.reference | TANAKA T, 1995, CANCER, V76, P1086, DOI 10.1002/1097-0142(19950915)76:6<1086::AID-CNCR2820760625>3.0.CO;2-8 | - |
hcfmusp.relation.reference | Westermann F, 2008, GENOME BIOL, V9, DOI 10.1186/gb-2008-9-10-r150 | - |
dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 10 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPE Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/ICr Artigos e Materiais de Revistas Científicas - LIM/03 Artigos e Materiais de Revistas Científicas - LIM/36 Artigos e Materiais de Revistas Científicas - LIM/52 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_SOUZA_Prognostic_Impact_of_MYCN_DDX1_TrkA_and_TrkC_2011.PDF Restricted Access | publishedVersion (English) | 276.78 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.