Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/2391
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLUGARESI, Rebeca
dc.contributor.authorLEME, Marco
dc.contributor.authorPAINELLI, Vitor de Salles
dc.contributor.authorMURAI, Igor Hisashi
dc.contributor.authorROSCHEL, Hamilton
dc.contributor.authorSAPIENZA, Marcelo Tatit
dc.contributor.authorLANCHA JUNIOR, Antonio Herbert
dc.contributor.authorGUALANO, Bruno
dc.date.accessioned2013-09-23T16:54:19Z
dc.date.available2013-09-23T16:54:19Z
dc.date.issued2013
dc.identifier.citationJOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION, v.10, article ID 26, 6p, 2013
dc.identifier.issn1550-2783
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2391
dc.description.abstractBackground: The aim of this study was to determine the effects of creatine supplementation on kidney function in resistance-trained individuals ingesting a high-protein diet. Methods: A randomized, double-blind, placebo-controlled trial was performed. The participants were randomly allocated to receive either creatine (20 g/d for 5 d followed by 5 g/d throughout the trial) or placebo for 12 weeks. All of the participants were engaged in resistance training and consumed a high-protein diet (i.e., >= 1.2 g/Kg/d). Subjects were assessed at baseline (Pre) and after 12 weeks (Post). Glomerular filtration rate was measured by Cr-51-EDTA clearance. Additionally, blood samples and a 24-h urine collection were obtained for other kidney function assessments. Results: No significant differences were observed for Cr-51-EDTA clearance throughout the trial (Creatine: Pre 101.42 +/- 13.11, Post 108.78 +/- 14.41 mL/min/1.73m(2); Placebo: Pre 103.29 +/- 17.64, Post 106.68 +/- 16.05 mL/min/1.73m(2); group x time interaction: F = 0.21, p = 0.64). Creatinine clearance, serum and urinary urea, electrolytes, proteinuria, and albuminuria remained virtually unchanged. Conclusions: A 12-week creatine supplementation protocol did not affect kidney function in resistance-trained healthy individuals consuming a high-protein diet; thus reinforcing the safety of this dietary supplement.
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) e Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
dc.language.isoeng
dc.publisherBIOMED CENTRAL LTD
dc.relation.ispartofJournal of the International Society of Sports Nutrition
dc.rightsopenAccess
dc.subjectGlomerular filtration rate
dc.subjectCr-51-EDTA clearance
dc.subjectSide effects
dc.subject.otherrenal-function
dc.subject.otherexercise
dc.subject.othermetabolism
dc.subject.otherhealth
dc.titleDoes long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet?
dc.typearticle
dc.rights.holderCopyright BIOMED CENTRAL LTD
dc.identifier.doi10.1186/1550-2783-10-26
dc.identifier.pmid23680457
dc.subject.wosNutrition & Dietetics
dc.subject.wosSport Sciences
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
hcfmusp.author.externalLUGARESI, Rebeca:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
hcfmusp.author.externalLEME, Marco:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
hcfmusp.author.externalPAINELLI, Vitor de Salles:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
hcfmusp.author.externalMURAI, Igor Hisashi:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
hcfmusp.author.externalROSCHEL, Hamilton:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil; Univ Sao Paulo, Div Rheumatol, Sch Med, BR-05508030 Sao Paulo, Brazil; Univ Sao Paulo, Lab Neuromuscular Adaptat Strength Training, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
hcfmusp.author.externalLANCHA JUNIOR, Antonio Herbert:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
hcfmusp.description.articlenumber26
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000319441000001
hcfmusp.origem.id2-s2.0-84878130794
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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dc.description.indexPubMed
hcfmusp.remissive.sponsorshipFAPESP
hcfmusp.citation.scopus27
hcfmusp.scopus.lastupdate2022-06-17-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - HC/InRad
Instituto de Radiologia - HC/InRad

Artigos e Materiais de Revistas Científicas - LIM/43
LIM/43 - Laboratório de Medicina Nuclear


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