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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLUGARESI, Rebeca
dc.contributor.authorLEME, Marco
dc.contributor.authorPAINELLI, Vitor de Salles
dc.contributor.authorMURAI, Igor Hisashi
dc.contributor.authorROSCHEL, Hamilton
dc.contributor.authorSAPIENZA, Marcelo Tatit
dc.contributor.authorLANCHA JUNIOR, Antonio Herbert
dc.contributor.authorGUALANO, Bruno
dc.identifier.citationJOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION, v.10, article ID 26, 6p, 2013
dc.description.abstractBackground: The aim of this study was to determine the effects of creatine supplementation on kidney function in resistance-trained individuals ingesting a high-protein diet. Methods: A randomized, double-blind, placebo-controlled trial was performed. The participants were randomly allocated to receive either creatine (20 g/d for 5 d followed by 5 g/d throughout the trial) or placebo for 12 weeks. All of the participants were engaged in resistance training and consumed a high-protein diet (i.e., >= 1.2 g/Kg/d). Subjects were assessed at baseline (Pre) and after 12 weeks (Post). Glomerular filtration rate was measured by Cr-51-EDTA clearance. Additionally, blood samples and a 24-h urine collection were obtained for other kidney function assessments. Results: No significant differences were observed for Cr-51-EDTA clearance throughout the trial (Creatine: Pre 101.42 +/- 13.11, Post 108.78 +/- 14.41 mL/min/1.73m(2); Placebo: Pre 103.29 +/- 17.64, Post 106.68 +/- 16.05 mL/min/1.73m(2); group x time interaction: F = 0.21, p = 0.64). Creatinine clearance, serum and urinary urea, electrolytes, proteinuria, and albuminuria remained virtually unchanged. Conclusions: A 12-week creatine supplementation protocol did not affect kidney function in resistance-trained healthy individuals consuming a high-protein diet; thus reinforcing the safety of this dietary supplement.
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) e Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
dc.relation.ispartofJournal of the International Society of Sports Nutrition
dc.subjectGlomerular filtration rate
dc.subjectCr-51-EDTA clearance
dc.subjectSide effects
dc.titleDoes long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet?
dc.rights.holderCopyright BIOMED CENTRAL LTD
dc.subject.wosNutrition & Dietetics
dc.subject.wosSport Sciences
dc.type.categoryoriginal article
dc.type.versionpublishedVersion, Rebeca:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil, Marco:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil, Vitor de Salles:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil, Igor Hisashi:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil, Hamilton:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil; Univ Sao Paulo, Div Rheumatol, Sch Med, BR-05508030 Sao Paulo, Brazil; Univ Sao Paulo, Lab Neuromuscular Adaptat Strength Training, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil JUNIOR, Antonio Herbert:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
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Appears in Collections:

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - HC/InRad
Instituto de Radiologia - HC/InRad

Artigos e Materiais de Revistas Científicas - LIM/43
LIM/43 - Laboratório de Medicina Nuclear

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