Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorWITKIN, Steven S.-
dc.contributor.authorMINIS, Evelyn-
dc.contributor.authorATHANASIOU, Aikaterini-
dc.contributor.authorLEIZER, Julie-
dc.contributor.authorLINHARES, Iara M.-
dc.identifier.citationCLINICAL AND VACCINE IMMUNOLOGY, v.24, n.10, article ID UNSP e00203-17, 9p, 2017-
dc.description.abstractChlamydia trachomatis is an obligate intracellular bacterium whose only natural host is humans. Although presenting as asymptomatic in most women, genital tract chlamydial infections are a leading cause of pelvic inflammatory disease, tubal factor infertility, and ectopic pregnancy. C. trachomatis has evolved successful mechanisms to avoid destruction by autophagy and the host immune system and persist within host epithelial cells. The intracellular form of this organism, the reticulate body, can enter into a persistent nonreplicative but viable state under unfavorable conditions. The infectious form of the organism, the elementary body, is again generated when the immune attack subsides. In its persistent form, C. trachomatis ceases to produce its major structural and membrane components, but synthesis of its 60-kDa heat shock protein (hsp60) is greatly upregulated and released from the cell. The immune response to hsp60, perhaps exacerbated by repeated cycles of productive infection and persistence, may promote damage to fallopian tube epithelial cells, scar formation, and tubal occlusion. The chlamydial and human hsp60 proteins are very similar, and hsp60 is one of the first proteins produced by newly formed embryos. Thus, the development of immunity to epitopes in the chlamydial hsp60 that are also present in the corresponding human hsp60 may increase susceptibility to pregnancy failure in infected women. Delineation of host factors that increase the likelihood that C. trachomatis will avoid immune destruction and survive within host epithelial cells and utilization of this knowledge to design individualized preventative and treatment protocols are needed to more effectively combat infections by this persistent pathogen.-
dc.relation.ispartofClinical and Vaccine Immunology-
dc.subjectChlamydia trachomatis-
dc.subjectheat shock protein-
dc.subjecttubal occlusion-
dc.subject.othermannose-binding lectin-
dc.subject.otherin-vitro fertilization-
dc.subject.othergene polymorphism-
dc.subject.othermouse embryo-
dc.titleChlamydia trachomatis: the Persistent Pathogen-
dc.rights.holderCopyright AMER SOC MICROBIOLOGY-
dc.subject.wosInfectious Diseases-
dc.type.versionpublishedVersion-, Steven S.:Weill Cornell Med, Dept Obstet & Gynecol, Div Immunol & Infect Dis, New York, NY USA-, Evelyn:Weill Cornell Med, Dept Obstet & Gynecol, Div Immunol & Infect Dis, New York, NY USA-, Aikaterini:Weill Cornell Med, Dept Obstet & Gynecol, Div Immunol & Infect Dis, New York, NY USA-, Julie:Weill Cornell Med, Dept Obstet & Gynecol, Div Immunol & Infect Dis, New York, NY USA-
hcfmusp.description.articlenumberUNSP e00203-17-
hcfmusp.relation.referenceAbdelRahman YM, 2005, FEMS MICROBIOL REV, V29, P949, DOI 10.1016/j.femsre.2005.03.002-
hcfmusp.relation.referenceAgrawal T, 2009, J REPROD IMMUNOL, V83, P173, DOI 10.1016/j.jri.2009.07.013-
hcfmusp.relation.referenceAiyar A, 2014, FRONT CELL INFECT MI, V4, DOI 10.3389/fcimb.2014.00072-
hcfmusp.relation.referenceAl-Younes HM, 2011, AUTOPHAGY, V7, P814, DOI 10.4161/auto.7.8.15597-
hcfmusp.relation.referenceAl-Younes HM, 2004, INFECT IMMUN, V72, P4751, DOI 10.1128/IAI.72.8.4751-4762.2004-
hcfmusp.relation.referenceAl-Zeer MA, 2013, AUTOPHAGY, V9, P50, DOI 10.4161/auto.22482-
hcfmusp.relation.referenceAl-Zeer MA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004588-
hcfmusp.relation.referenceBastidas RJ, 2013, CSH PERSPECT MED, V3, DOI 10.1101/cshperspect.a010256-
hcfmusp.relation.referenceBavoil PM, 2014, FRONT CELL INFECT MI, V4, DOI 10.3389/fcimb.2014.00027-
hcfmusp.relation.referenceBEATTY WL, 1994, INFECT IMMUN, V62, P3705-
hcfmusp.relation.referenceBEATTY WL, 1993, P NATL ACAD SCI USA, V90, P3998, DOI 10.1073/pnas.90.9.3998-
hcfmusp.relation.referenceBENSAUDE O, 1983, EMBO J, V2, P173-
hcfmusp.relation.referenceBrunham RC, 2005, NAT REV IMMUNOL, V5, P149, DOI 10.1038/nri1551-
hcfmusp.relation.referenceBulut Y, 2002, J IMMUNOL, V168, P1435-
hcfmusp.relation.referenceDaponte A, 2012, J REPROD IMMUNOL, V93, P102, DOI 10.1016/j.jri.2012.01.003-
hcfmusp.relation.referenceDarville T, 2010, J INFECT DIS, V201, pS114, DOI 10.1086/652397-
hcfmusp.relation.referencede la Maza LM, 2017, CLIN VACCINE IMMUNOL, V24, DOI [10.1128/CVI.00543-16, 10.1128/cvi.00543-16]-
hcfmusp.relation.referenceDeka S, 2006, CELL MICROBIOL, V8, P149, DOI 10.1111/j.1462-5822.2005.00608.x-
hcfmusp.relation.referenceEckert LO, 1997, J INFECT DIS, V175, P1453-
hcfmusp.relation.referenceExpert Committee on Pelvic Inflammatory Disease, 1991, SEX TRANSM DIS, V18, P46-
hcfmusp.relation.referenceEggert-Kruse W, 2014, FERTIL STERIL, V101, P1675, DOI 10.1016/j.fertnstert.2014.02.048-
hcfmusp.relation.referenceEleuterio J, 2015, INT J STD AIDS, V26, P960, DOI 10.1177/0956462414563627-
hcfmusp.relation.referenceELIAS D, 1990, P NATL ACAD SCI USA, V87, P1576, DOI 10.1073/pnas.87.4.1576-
hcfmusp.relation.referenceElwell C, 2016, NAT REV MICROBIOL, V14, P385, DOI 10.1038/nrmicro.2016.30-
hcfmusp.relation.referenceEquils O, 2006, J IMMUNOL, V177, P1257-
hcfmusp.relation.referenceFan T, 1998, J EXP MED, V187, P487, DOI 10.1084/jem.187.4.487-
hcfmusp.relation.referenceFolger AT, 2014, MATERN CHILD HLTH J, V18, P1795, DOI 10.1007/s10995-013-1423-6-
hcfmusp.relation.referenceGeisler WM, 2010, J INFECT DIS, V201, pS104, DOI 10.1086/652402-
hcfmusp.relation.referenceGieffers J, 2004, ANTIMICROB AGENTS CH, V48, P1402, DOI 10.1128/AAC.48.4.1402-1405.2004-
hcfmusp.relation.referenceGottlieb SL, 2010, J INFECT DIS, V201, pS85, DOI 10.1086/652392-
hcfmusp.relation.referenceHaggerty CL, 2010, J INFECT DIS, V201, pS134, DOI 10.1086/652395-
hcfmusp.relation.referenceHUTCHINSON GR, 1979, BRIT J VENER DIS, V55, P194-
hcfmusp.relation.referenceHybiske K, 2007, P NATL ACAD SCI USA, V104, P11430, DOI 10.1073/pnas.0703218104-
hcfmusp.relation.referenceJakus S, 2008, AM J REPROD IMMUNOL, V59, P85, DOI 10.1111/j.1600-0897.2007.00539.x-
hcfmusp.relation.referenceJINDAL S, 1989, MOL CELL BIOL, V9, P2279-
hcfmusp.relation.referenceKanninen TT, 2014, BJOG-INT J OBSTET GY, V121, P958, DOI 10.1111/1471-0528.12755-
hcfmusp.relation.referenceKarlin S, 2000, P NATL ACAD SCI USA, V97, P11348, DOI 10.1073/pnas.97.21.11348-
hcfmusp.relation.referenceLichtenwalner AB, 2004, INFECT IMMUN, V72, P1159, DOI 10.1128/IAI.72.2.1159-1161.2004-
hcfmusp.relation.referenceLINDQUIST S, 1988, ANNU REV GENET, V22, P631, DOI 10.1146/
hcfmusp.relation.referenceLinhares IM, 2010, CELL STRESS CHAPERON, V15, P467, DOI 10.1007/s12192-010-0171-4-
hcfmusp.relation.referenceMcClarty G, 2007, CURR OPIN MICROBIOL, V10, P47, DOI 10.1016/j.mib.2006.12.003-
hcfmusp.relation.referenceMiguel RDV, 2017, INFECT IMMUN, V85, DOI 10.1128/IAI.00129-17-
hcfmusp.relation.referenceMiles SM, 2017, FERTIL STERIL, V107, P813, DOI 10.1016/j.fertnstert.2016.11.028-
hcfmusp.relation.referenceMizushima N, 2011, CELL, V147, P728, DOI 10.1016/j.cell.2011.10.026-
hcfmusp.relation.referenceMoreno I, 2016, AM J OBSTET GYNECOL, V215, P684, DOI 10.1016/j.ajog.2016.09.075-
hcfmusp.relation.referenceMorrison RP, 1992, SEXUALLY TRANSMITTED, P57-
hcfmusp.relation.referenceMUNK ME, 1989, J IMMUNOL, V143, P2844-
hcfmusp.relation.referenceMuramatsu MK, 2016, INFECT IMMUN, V84, P2791, DOI 10.1128/IAI.00356-16-
hcfmusp.relation.referenceNans A, 2015, MICROBES INFECT, V17, P727, DOI 10.1016/j.micinf.2015.08.004-
hcfmusp.relation.referenceNardini P, 2016, SCI REP-UK, V6, DOI 10.1038/srep29024-
hcfmusp.relation.referenceNasioudis D, 2017, BJOG-INT J OBSTET GY, V124, P61, DOI 10.1111/1471-0528.14209-
hcfmusp.relation.referenceNeth O, 2000, INFECT IMMUN, V68, P688, DOI 10.1128/IAI.68.2.688-693.2000-
hcfmusp.relation.referenceNeuer A, 1998, HUM REPROD, V13, P987, DOI 10.1093/humrep/13.4.987-
hcfmusp.relation.referenceOmsland A, 2014, FEMS MICROBIOL REV, V38, P779, DOI 10.1111/1574-6976.12059-
hcfmusp.relation.referenceOndondo BO, 2009, J INFECT DIS, V199, P1771, DOI 10.1086/599095-
hcfmusp.relation.referencePaavonen J, 1999, HUM REPROD UPDATE, V5, P433, DOI 10.1093/humupd/5.5.433-
hcfmusp.relation.referencePachikara N, 2009, FEMS MICROBIOL LETT, V292, P240, DOI 10.1111/j.1574-6968.2009.01494.x-
hcfmusp.relation.referencePeeling RW, 1996, EMERG INFECT DIS, V2, P307-
hcfmusp.relation.referencePeeling RW, 1999, J INFECT DIS, V180, P774, DOI 10.1086/314919-
hcfmusp.relation.referencePeeling RW, 1997, J INFECT DIS, V175, P1153-
hcfmusp.relation.referencePerez-Munoz ME, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0268-4-
hcfmusp.relation.referenceRami A, 2008, AUTOPHAGY, V4, P422-
hcfmusp.relation.referenceRaulston JE, 1997, INFECT IMMUN, V65, P4539-
hcfmusp.relation.referenceRavel J, 2011, P NATL ACAD SCI USA, V108, P4680, DOI 10.1073/pnas.1002611107-
hcfmusp.relation.referenceRekart ML, 2008, SEX TRANSM INFECT, V84, P87, DOI 10.1136/sti.2007.027938-
hcfmusp.relation.referenceRodel J, 1998, INFECT IMMUN, V66, P4491-
hcfmusp.relation.referenceRours GIJG, 2011, EUR J EPIDEMIOL, V26, P493, DOI 10.1007/s10654-011-9586-1-
hcfmusp.relation.referenceSasaki-Imamura T, 2011, FEMS MICROBIOL LETT, V322, P51, DOI 10.1111/j.1574-6968.2011.02329.x-
hcfmusp.relation.referenceSHEMER Y, 1985, INFECT IMMUN, V48, P592-
hcfmusp.relation.referenceSpandorfer SD, 1999, HUM REPROD, V14, P60, DOI 10.1093/humrep/14.1.60-
hcfmusp.relation.referenceSwanson AF, 1998, INFECT IMMUN, V66, P1607-
hcfmusp.relation.referenceSziller I, 2007, HUM REPROD, V22, P1861, DOI 10.1093/humrep/dem107-
hcfmusp.relation.referenceSziller I, 2008, AM J REPROD IMMUNOL, V59, P99, DOI 10.1111/j.1600-0897.2007.00553.x-
hcfmusp.relation.referenceTiitinen A, 2006, HUM REPROD, V21, P1533, DOI 10.1093/humrep/de1014-
hcfmusp.relation.referenceTurner MW, 2003, MOL IMMUNOL, V40, P423, DOI 10.1016/S0161-5890(03)00155-X-
hcfmusp.relation.referenceVasilevsky S, 2014, CLIN MICROBIOL REV, V27, P346, DOI 10.1128/CMR.00105-13-
hcfmusp.relation.referenceWelter-Stahl L, 2006, CELL MICROBIOL, V8, P1047, DOI 10.1111/j.1462-5822.2006.00686.x-
hcfmusp.relation.referenceWitkin SS, 2017, BJOG-INT J OBSTET GY, V124, P606, DOI 10.1111/1471-0528.14390-
hcfmusp.relation.referenceWitkin S S, 1999, Infect Dis Obstet Gynecol, V7, P35, DOI 10.1155/S1064744999000083-
hcfmusp.relation.referenceWITKIN SS, 1994, AM J OBSTET GYNECOL, V171, P455-
hcfmusp.relation.referenceWITKIN SS, 1994, AM J OBSTET GYNECOL, V171, P1208-
hcfmusp.relation.referenceWITKIN SS, 1993, J INFECT DIS, V167, P1379-
hcfmusp.relation.referenceWitkin SS, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3003944-
hcfmusp.relation.referenceWyrick PB, 2010, J INFECT DIS, V201, pS88, DOI 10.1086/652394-
hcfmusp.relation.referenceYI YJ, 1993, INFECT IMMUN, V61, P1117-
hcfmusp.relation.referenceZhong GM, 2001, J EXP MED, V193, P935, DOI 10.1084/jem.193.8.935-
hcfmusp.relation.referenceZhong GM, 2009, TRENDS MICROBIOL, V17, P467, DOI 10.1016/j.tim.2009.07.007-
hcfmusp.relation.referenceZiklo N, 2016, TRENDS MICROBIOL, V24, P750, DOI 10.1016/j.tim.2016.05.007-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/58
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular

Files in This Item:
File Description SizeFormat 
  Restricted Access
publishedVersion(English)210.4 kBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.