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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorMORENO, Maria Cecilia Rey-
dc.contributor.authorFUSSELL, Karma C.-
dc.contributor.authorGROETERS, Sibylle-
dc.contributor.authorSCHNEIDER, Steffen-
dc.contributor.authorSTRAUSS, Volker-
dc.contributor.authorSTINCHCOMBE, Stefan-
dc.contributor.authorFEGERT, Ivana-
dc.contributor.authorVERAS, Mariana-
dc.contributor.authorRAVENZWAAY, Bennard van-
dc.date.accessioned2013-09-23T16:55:56Z-
dc.date.available2013-09-23T16:55:56Z-
dc.date.issued2013-
dc.identifier.citationBIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY, v.98, n.3, p.208-221, 2013-
dc.identifier.issn1542-9733-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2458-
dc.description.abstractEpoxiconazole (CAS-No. 133855-98-8) was recently shown to cause both a marked depletion of maternal estradiol blood levels and a significantly increased incidence of late fetal mortality when administered to pregnant rats throughout gestation (GD 7-18 or 21); estradiol supplementation prevented this epoxiconazole effect in rats (Stinchcombe et al., 2013), indicating that epoxiconazole-mediated estradiol depletion is a critical key event for induction of late fetal resorptions in rats. For further elucidation of the mode of action, the placentas from these modified prenatal developmental toxicity experiments with 23 and 50 mg/kg bw/d epoxiconazole were subjected to a detailed histopathological examination. This revealed dose-dependent placental degeneration characterized by cystic dilation of maternal sinuses in the labyrinth, leading to rupture of the interhemal membrane. Concomitant degeneration occurred in the trophospongium. Both placentas supporting live fetuses and late fetal resorptions were affected; the highest degree of severity was observed in placentas with late resorptions. Placental degeneration correlated with a severe decline in maternal serum estradiol concentration. Supplementation with 0.5 and 1.0 g of the synthetic estrogen estradiol cyclopentylpropionate per day reduced the severity of the degeneration in placentas with live fetuses. The present study demonstrates that both the placental degeneration and the increased incidence of late fetal resorptions are due to decreased levels of estrogen, since estrogen supplementation ameliorates the former and abolishes the latter. Birth Defects Res (Part B) 98:208-221, 2013. (c) 2013 Wiley Periodicals, Inc.-
dc.language.isoeng-
dc.publisherWILEY-BLACKWELL-
dc.relation.ispartofBirth Defects Research Part B-Developmental and Reproductive Toxicology-
dc.rightsrestrictedAccess-
dc.subjectepoxiconazole-
dc.subjectrat-
dc.subjectplacenta-
dc.subjecthistopathology-
dc.subjectplacental degeneration-
dc.subject.otherin-vivo-
dc.subject.otherpregnancy-
dc.subject.othergestation-
dc.subject.otherestrogen-
dc.subject.othermurine-
dc.subject.otherexpression-
dc.subject.otherfungicides-
dc.subject.othergrowth-
dc.subject.othercells-
dc.subject.othermodel-
dc.titleEpoxiconazole-Induced Degeneration in Rat Placenta and the Effects of Estradiol Supplementation-
dc.typearticle-
dc.rights.holderCopyright WILEY-BLACKWELL-
dc.identifier.doi10.1002/bdrb.21055-
dc.identifier.pmid23749492-
dc.subject.wosOncology-
dc.subject.wosGenetics & Heredity-
dc.subject.wosToxicology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalMORENO, Maria Cecilia Rey:BASF SE, Dept Expt Toxicol & Ecol, D-67056 Ludwigshafen, Germany-
hcfmusp.author.externalFUSSELL, Karma C.:BASF SE, Dept Expt Toxicol & Ecol, D-67056 Ludwigshafen, Germany-
hcfmusp.author.externalGROETERS, Sibylle:BASF SE, Dept Expt Toxicol & Ecol, D-67056 Ludwigshafen, Germany-
hcfmusp.author.externalSCHNEIDER, Steffen:BASF SE, Dept Expt Toxicol & Ecol, D-67056 Ludwigshafen, Germany-
hcfmusp.author.externalSTRAUSS, Volker:BASF SE, Dept Expt Toxicol & Ecol, D-67056 Ludwigshafen, Germany-
hcfmusp.author.externalSTINCHCOMBE, Stefan:BASF SE, Dept Prod Safety Regulat Toxicol & Ecol, D-67056 Ludwigshafen, Germany-
hcfmusp.author.externalFEGERT, Ivana:BASF SE, Dept Prod Safety Regulat Toxicol & Ecol, D-67056 Ludwigshafen, Germany-
hcfmusp.author.externalRAVENZWAAY, Bennard van:BASF SE, Dept Expt Toxicol & Ecol, D-67056 Ludwigshafen, Germany-
hcfmusp.description.beginpage208-
hcfmusp.description.endpage221-
hcfmusp.description.issue3-
hcfmusp.description.volume98-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000320126300002-
hcfmusp.origem.id2-s2.0-84878993065-
hcfmusp.publisher.cityHOBOKEN-
hcfmusp.publisher.countryUSA-
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dc.description.indexMEDLINE-
hcfmusp.citation.scopus19-
hcfmusp.scopus.lastupdate2022-05-06-
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Artigos e Materiais de Revistas Científicas - LIM/05
LIM/05 - Laboratório de Poluição Atmosférica Experimental

Artigos e Materiais de Revistas Científicas - LIM/25
LIM/25 - Laboratório de Endocrinologia Celular e Molecular

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


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