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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorBALDO, Marcelo Perim-
dc.contributor.authorCUNHA, Roberto S.-
dc.contributor.authorMOLINA, Maria del Carmen B.-
dc.contributor.authorCHOR, Dora-
dc.contributor.authorGRIEP, Rosane H.-
dc.contributor.authorDUNCAN, Bruce B.-
dc.contributor.authorSCHMIDT, Maria Ines-
dc.contributor.authorRIBEIRO, Antonio L. P.-
dc.contributor.authorBARRETO, Sandhi M.-
dc.contributor.authorLOTUFO, Paulo A.-
dc.contributor.authorBENSENOR, Isabela M.-
dc.contributor.authorPEREIRA, Alexandre C.-
dc.contributor.authorMILL, Jose Geraldo-
dc.identifier.citationINTERNATIONAL JOURNAL OF CARDIOLOGY, v.251, p.90-95, 2018-
dc.description.abstractBackground: Aging declines essential physiological functions, and the vascular system is strongly affected by artery stiffening. We intended to define the age-and sex-specific reference values for carotid-to-femoral pulse wave velocity (cf-PWV) in a sample free of major risk factors. Methods and results: The ELSA-Brasil study enrolled 15,105 participants aged 35-74 years. The healthy sample was achieved by excluding diabetics, those over the optimal and normal blood pressure levels, body mass index <= 18.5 or >= 25 kg/m(2), current and former smokers, and those with self-report of previous cardiovascular disease. After exclusions, the sample consisted of 2158 healthy adults (1412 women). Although cf-PWV predictors were similar between sex (age, mean arterial pressure (MAP) and heart rate), cf-PWV was higher in men (8.74 +/- 1.15 vs. 8.31 +/- 1.13 m/s; adjusted for age and MAP, P < 0.001) for all age intervals. When divided by MAP categories, cf-PWV was significantly higher in those which MAP >= 85 mm Hg, regardless of sex, and for all age intervals. Risk factors for arterial stiffening in the entire ELSA-Brasil population (n = 15,105) increased by twice the age-related slope of cf-PWV growth, regardless of sex (0.0919 +/- 0.182 vs. 0.0504 +/- 0.153 m/s per year for men, 0.0960 +/- 0.173 vs. 0.0606 +/- 0.139 m/s per year for women). Conclusions: cf-PWVis different between men and women and even in an optimal and normal range of MAP and free of other classical risk factors for arterial stiffness, reference values for cf-PWV should take into account MAP levels. Also, the presence of major risk factors in the general population doubles the age-related rise in cf-PWV.-
dc.description.sponsorshipBrazilian Ministry of Health (Department of Science and Technology)-
dc.description.sponsorshipMinistry of Science, Technology and Innovation (FINEP, Financiadora de Estudos e Projetos) [01 06 0010.00, 01 06 0212.00, 01 06 0300.00, 01 06 0278.00, 01 06 0115.00, 01 06 0071.00]-
dc.description.sponsorshipCNPq (the National Council for Scientific and Technological Development)-
dc.relation.ispartofInternational Journal of Cardiology-
dc.subjectArterial stiffness-
dc.subjectReference value-
dc.subjectHealthy sample-
dc.subjectSex differences-
dc.subjectRisk factors-
dc.subject.otherarterial stiffness-
dc.subject.othercardiovascular risk-
dc.subject.otherhypertensive patients-
dc.subject.otheraortic stiffness-
dc.titleCarotid-femoral pulse wave velocity in a healthy adult sample: The ELSA-Brasil study-
dc.rights.holderCopyright ELSEVIER IRELAND LTD-
dc.subject.wosCardiac & Cardiovascular Systems-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Marcelo Perim:Montes Claros State Univ, Dept Pathophysiol, Montes Claros, MG, Brazil-, Roberto S.:Univ Fed Espirito Santo, Dept Physiol Sci, Ave Marechal Campos 1468, BR-29042755 Vitoria, ES, Brazil-, Maria del Carmen B.:Univ Fed Espirito Santo, Post Grad Programme Publ Hlth, Vitoria, ES, Brazil-, Dora:Fundacao Oswaldo Cruz, Escola Nacl Saude Publ, Rio De Janeiro, Brazil-, Rosane H.:Fundacao Oswaldo Cruz, Lab Educ Ambiente & Saude, Inst Oswaldo Cruz, Rio De Janeiro, Brazil-, Bruce B.:Univ Fed Rio Grande do Sul, Fac Med, Porto Alegre, RS, Brazil; Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil-, Maria Ines:Univ Fed Rio Grande do Sul, Fac Med, Porto Alegre, RS, Brazil; Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil-, Antonio L. P.:Univ Fed Minas Gerais, Fac Med, Belo Horizonte, MG, Brazil; Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG, Brazil-, Sandhi M.:Univ Fed Minas Gerais, Fac Med, Belo Horizonte, MG, Brazil; Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG, Brazil-, Jose Geraldo:Univ Fed Espirito Santo, Dept Physiol Sci, Ave Marechal Campos 1468, BR-29042755 Vitoria, ES, Brazil-
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/13
LIM/13 - Laboratório de Genética e Cardiologia Molecular

Artigos e Materiais de Revistas Científicas - LIM/20
LIM/20 - Laboratório de Terapêutica Experimental

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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