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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorLIMA, Melchior Luiz-
dc.contributor.authorFIORELLI, Alfredo Inacio-
dc.contributor.authorVASSALLO, Dalton Valentim-
dc.contributor.authorPINHEIRO, Bruno Botelho-
dc.contributor.authorSTOLF, Noedir Antonio Groppo-
dc.contributor.authorGOMES, Otoni Moreira-
dc.identifier.citationREVISTA BRASILEIRA DE CIRURGIA CARDIOVASCULAR, v.27, n.1, p.110-116, 2012-
dc.description.abstractBackground: There is a growing need to improve myocardial protection, which will lead to better performance of cardiac operations and reduce morbidity and mortality. Therefore, the objective of this study was to compare the efficacy of myocardial protection solution using both intracellular and extracellular crystalloid type regarding the performance of the electrical conduction system, left ventricular contractility and edema, after being subjected to ischemic arrest and reperfusion. Methods: Hearts isolated from male Wistar (n=32) rats were prepared using Langendorff method and randomly divided equally into four groups according the cardioprotective solutions used Krebs-Henseleit-Buffer (KHB), Bretschneider-HTK (HTK), St. Thomas-1 (STH-1) and Celsior (CEL). After stabilization with KHB at 37 degrees C, baseline values (control) were collected for heart rate (HR), left ventricle systolic pressure (LVSP), maximum first derivate of rise left ventricular pressure (+dP/dt), maximum first derivate of fall left ventricular pressure (-dP/dt) and coronary flow (CF). The hearts were then perfused at 10 degrees C for 5 min and kept for 2 h in static ischemia at 20 degrees C in each cardioprotective solution. Data evaluation was done using analysis of variance in completely randomized One-Way ANOVA and Tukey's test for multiple comparisons. The level of statistical significance chosen was P<0.05. Results: HR was restored with all the solutions used. The evaluation of left ventricular contractility (LVSP, +dP/dt and -dP/dt) showed that treatment with CEL solution was better compared to other solutions. When analyzing the CF, the HTK solution showed better protection against edema. Conclusion: Despite the cardioprotective crystalloid solutions studied are not fully able to suppress the deleterious effects of ischemia and reperfusion in the rat heart, the CEL solution had significantly higher results followed by HTK>KHB>STH-1.-
dc.description.sponsorshipBrazilian Association for Organ Transplant (ABTO)-
dc.relation.ispartofRevista Brasileira de Cirurgia Cardiovascular-
dc.subjectHeart arrest, induced-
dc.subjectMyocardial reperfusion injury-
dc.subjectCardioplegic solutions-
dc.subjectVentricular function, left-
dc.subjectRats, Wistar-
dc.subject.otherreperfusion injury-
dc.subject.othertemperature threshold-
dc.subject.otherrabbit heart-
dc.titleComparative experimental study of myocardial protection with crystalloid solutions for heart transplantation-
dc.rights.holderCopyright SOC BRASIL CIRURGIA CARDIOVASC-
dc.subject.wosCardiac & Cardiovascular Systems-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Melchior Luiz:Cardiovasc Surg Cardiovasc Fdn St Francis, Belo Horizonte, MG, Brazil; AMBPresidente DEPEX BSCVS, Vitoria, ES, Brazil-, Dalton Valentim:Univ Fed Rio de Janeiro, BR-21941 Rio De Janeiro, Brazil-, Bruno Botelho:Cardiovasc Surg Cardiovasc Fdn St Francis Assisi, Goiania, Go, Brazil-, Otoni Moreira:Univ Sao Paulo, Fed Univ Minas Gerais UFMG, Cardiovasc Fdn St Francis Assisi Servcor, Belo Horizonte, MG, Brazil-
hcfmusp.publisher.citySAO PAULO SP-
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Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCP
Departamento de Cardio-Pneumologia - FM/MCP

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/11
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação

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