Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/2513
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | CONDE, Sandro Jose | - |
dc.contributor.author | LUVIZOTTO, Renata de Azevedo Melo | - |
dc.contributor.author | SIBIO, Maria Teresa de | - |
dc.contributor.author | SARAIVA, Patricia Pinto | - |
dc.contributor.author | BRENTANI, Maria Mitzi | - |
dc.contributor.author | NOGUEIRA, Celia Regina | - |
dc.date.accessioned | 2013-10-02T19:19:34Z | - |
dc.date.available | 2013-10-02T19:19:34Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA, v.56, n.4, p.238-243, 2012 | - |
dc.identifier.issn | 0004-2730 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/2513 | - |
dc.description.abstract | Objective: The aim of this study was to determine thyroid hormone (TH) profile in postmenopausal patients with breast cancer (BC). Subjects and methods: 12 CaM patients stages I or II, without interventions that could interfere with tumor progression were selected, as well as and a control group with 18 postmenopausal women without CaM. We measured serum anti-thyroperoxidase antibody (TPOAB), thyroid-stimulating hormone (TSH), free thyroxine (T4L), estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH), before and after surgery, besides immunohistochemistry for estrogen (ER) and progesterone (PR) receptors. Results: Four patients with CaM showed changes in thyroid hormone profile: two had hyperthyroidism, one hypothyroidism, and one was positive for TPO-AB. All of them positive for ER and PR.TSH levels in breast cancer patients were not different from levels found in the control group (1.89 +/- 1.56 vs. 2.86 +/- 3.12 mIU/mL), but the levels of T4L in patients with CaM were statistically higher than those of the control group (1.83 +/- 0.57 vs. 1.10 +/- 0.20 ng/dL). Conclusion: These results reinforce the need for assessment of thyroid status in CaM patients, since in the absence of E2, changes in clinical HTs can act in E2-controlled processes. Arq Bras Endocrinol Metab. 2012;56(4):238-43 | - |
dc.description.abstract | Objetivo: Verificar o perfil dos hormônios tireóideos (HTs) em pacientes pós-menopausa portadoras de carcinoma de mama (CaM). Sujeitos e métodos: Participaram 12 pacientes com CaM em estádio I ou II sem intervenções que pudessem interferir na progressão tumoral e um grupo controle com 18 pacientes em pós-menopausa sem CaM. Foram dosados os níveis séricos de anticorpo antitiroperoxidase (TPOAB), hormônio estimulante da tireoide (TSH), tiroxina livre (T4L), estradiol (E2), hormônio folículo estimulante (FSH) e hormônio luteinizante (LH) antes e após a cirurgia, e realizada a imunoistoquímica dos receptores de estrógeno (ER) e progesterona (PR). Resultados: Quatro pacientes com CaM apresentaram alterações do perfil hormonal tireoidiano: dois hipertireoidismo, um hipotireoidismo e positividade TPO-AB, todas com ER e PR positivos. Os níveis de TSH dessas pacientes não foram diferentes dos níveis encontrados no grupo controle (1,89 ± 1,56 vs . 2,86 ± 3,12 mUI/mL), porém os níveis de T4L nas pacientes com CaM foram estatisticamente maiores que o controle (1,83 ± 0,57 vs. 1,10 ± 0,20 ng/dL). Conclusão: Esses resultados reforçam a necessidade de avaliação do status tireoidiano em pacientes com CaM, uma vez que, na ausência de E2, mudanças clínicas nos HTs podem atuar em vias controladas pelo E2. Arq Bras Endocrinol Metab. 2012;56(4):238-43 | - |
dc.language.iso | por | - |
dc.publisher | SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA | - |
dc.relation.ispartof | Arquivos Brasileiros de Endocrinologia e Metabologia | - |
dc.rights | openAccess | - |
dc.subject | Thyroid hormones | - |
dc.subject | breast neoplasms | - |
dc.subject | hyperthyroidism | - |
dc.subject | postmenopause | - |
dc.subject | Hormônios tireóideos | - |
dc.subject | neoplasias da mama | - |
dc.subject | hipertireoidismo | - |
dc.subject | pós-menopausa | - |
dc.subject.other | cell-lines | - |
dc.subject.other | mammary cancer | - |
dc.subject.other | estrogen | - |
dc.subject.other | disease | - |
dc.subject.other | growth | - |
dc.subject.other | triiodothyronine | - |
dc.subject.other | proliferation | - |
dc.subject.other | women | - |
dc.subject.other | risk | - |
dc.subject.other | hypothyroidism | - |
dc.title | Perfil dos hormônios da tireoide em pacientes com câncer de mama em estado de menopausa | - |
dc.title.alternative | Thyroid hormone profile in breast cancer patients in postmenopause | - |
dc.type | article | - |
dc.rights.holder | Copyright SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA | - |
dc.identifier.doi | 10.1590/S0004-27302012000400004 | - |
dc.identifier.pmid | 22790468 | - |
dc.subject.wos | Endocrinology & Metabolism | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | CONDE, Sandro Jose:Univ Estadual Paulista Julio de Mesquista Filho U, Dept Clin Med, Botucatu, SP, Brazil | - |
hcfmusp.author.external | LUVIZOTTO, Renata de Azevedo Melo:Univ Estadual Paulista Julio de Mesquista Filho U, Dept Clin Med, Botucatu, SP, Brazil | - |
hcfmusp.author.external | SIBIO, Maria Teresa de:Univ Estadual Paulista Julio de Mesquista Filho U, Dept Clin Med, Botucatu, SP, Brazil | - |
hcfmusp.author.external | SARAIVA, Patricia Pinto:Univ Sagrado Coracao, Dept Odontol, Bauru, SP, Brazil | - |
hcfmusp.author.external | NOGUEIRA, Celia Regina:Univ Estadual Paulista Julio de Mesquista Filho U, Dept Clin Med, Botucatu, SP, Brazil | - |
hcfmusp.description.beginpage | 238 | - |
hcfmusp.description.endpage | 243 | - |
hcfmusp.description.issue | 4 | - |
hcfmusp.description.volume | 56 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84864048042 | - |
hcfmusp.origem.id | WOS:000306369200004 | - |
hcfmusp.origem.id | SCIELO:S0004-27302012000400004 | - |
hcfmusp.publisher.city | RIO DE JANEIRO, RJ | - |
hcfmusp.publisher.country | BRAZIL | - |
hcfmusp.relation.reference | ADAMOPOULOS DA, 1986, CANCER, V57, P125, DOI 10.1002/1097-0142(19860101)57:1<125::AID-CNCR2820570125>3.0.CO;2-4 | - |
hcfmusp.relation.reference | BRINTON LA, 1984, J CHRON DIS, V37, P877, DOI 10.1016/0021-9681(84)90062-6 | - |
hcfmusp.relation.reference | Cestari SH, 2009, ARQ BRAS ENDOCRINOL, V53, P859, DOI 10.1590/S0004-27302009000700010 | - |
hcfmusp.relation.reference | Condel SJ, 2008, J ENDOCRINOL INVEST, V31, P1047 | - |
hcfmusp.relation.reference | Conde SJ, 2012, EUR J CANCER PREV, V21, P333, DOI 10.1097/CEJ.0b013e32834dbc42 | - |
hcfmusp.relation.reference | Dinda S, 2002, ONCOGENE, V21, P761, DOI 10.1038/sj.onc.1205136 | - |
hcfmusp.relation.reference | Giani C, 1996, J CLIN ENDOCR METAB, V81, P990, DOI 10.1210/jc.81.3.990 | - |
hcfmusp.relation.reference | GOLDMAN MB, 1990, EPIDEMIOL REV, V12, P16 | - |
hcfmusp.relation.reference | HEDLEY AJ, 1981, LANCET, V1, P131 | - |
hcfmusp.relation.reference | Ito K, 1975, Lancet, V2, P1119 | - |
hcfmusp.relation.reference | Jensen EV, 2001, P NATL ACAD SCI USA, V98, P15197, DOI 10.1073/pnas.211556298 | - |
hcfmusp.relation.reference | KALACHE A, 1982, BRIT J SURG, V69, P434, DOI 10.1002/bjs.1800690731 | - |
hcfmusp.relation.reference | KAPDI CC, 1976, JAMA-J AM MED ASSOC, V236, P1124, DOI 10.1001/jama.236.10.1124 | - |
hcfmusp.relation.reference | LEMAIRE M, 1986, EUR J CANCER CLIN ON, V22, P301, DOI 10.1016/0277-5379(86)90395-0 | - |
hcfmusp.relation.reference | MITTRA I, 1974, LANCET, V1, P885 | - |
hcfmusp.relation.reference | Moossa A R, 1973, Ann R Coll Surg Engl, V53, P178 | - |
hcfmusp.relation.reference | MUHLBOCK O, 1959, CANCER RES, V19, P402 | - |
hcfmusp.relation.reference | MUSTACCHI P, 1977, JAMA-J AM MED ASSOC, V237, P1446, DOI 10.1001/jama.237.14.1446 | - |
hcfmusp.relation.reference | NATOLI C, 1983, BREAST CANCER RES TR, V3, P23, DOI 10.1007/BF01806231 | - |
hcfmusp.relation.reference | NISKER J A, 1981, Clinical Obstetrics and Gynecology, V24, P301, DOI 10.1097/00003081-198103000-00025 | - |
hcfmusp.relation.reference | Nogueira CR, 1996, J STEROID BIOCHEM, V59, P271, DOI 10.1016/S0960-0760(96)00117-3 | - |
hcfmusp.relation.reference | PERRY M, 1978, ANN ROY COLL SURG, V60, P290 | - |
hcfmusp.relation.reference | RASMUSSON B, 1987, EUR J CANCER CLIN ON, V23, P553, DOI 10.1016/0277-5379(87)90319-1 | - |
hcfmusp.relation.reference | ROSE DP, 1978, CANCER, V41, P666, DOI 10.1002/1097-0142(197802)41:2<666::AID-CNCR2820410234>3.0.CO;2-H | - |
hcfmusp.relation.reference | Saraiva PP, 2005, BRAZ J MED BIOL RES, V38, P761, DOI 10.1590/S0100-879X2005000500014 | - |
hcfmusp.relation.reference | SCHMIDT GH, 1967, ENDOCRINOLOGY, V81, P14 | - |
hcfmusp.relation.reference | SICHER K, 1967, BRIT J CANCER, V21, P512, DOI 10.1038/bjc.1967.60 | - |
hcfmusp.relation.reference | Smyth PPA, 1996, J CLIN ENDOCR METAB, V81, P937, DOI 10.1210/jc.81.3.937 | - |
hcfmusp.relation.reference | Smyth PPA, 1998, J CLIN ENDOCR METAB, V83, P2711, DOI 10.1210/jc.83.8.2711 | - |
hcfmusp.relation.reference | SORRENTINO JM, 1976, J NATL CANCER I, V56, P1155 | - |
hcfmusp.relation.reference | SPENCER JGC, 1954, BRIT J CANCER, V8, P393, DOI 10.1038/bjc.1954.41 | - |
hcfmusp.relation.reference | STEWART AJ, 1990, J BIOL CHEM, V265, P21172 | - |
hcfmusp.relation.reference | TAKATANI O, 1989, CANCER RES, V49, P3109 | - |
hcfmusp.relation.reference | THOMAS BS, 1983, EUR J CANCER CLIN ON, V19, P1213, DOI 10.1016/0277-5379(83)90198-0 | - |
hcfmusp.relation.reference | TOPPER YJ, 1980, PHYSIOL REV, V60, P1049 | - |
hcfmusp.relation.reference | Turken O, 2003, BREAST CANCER RES, V5, pR110, DOI 10.1186/bcr609 | - |
hcfmusp.relation.reference | Vasudevan N, 2001, MOL BRAIN RES, V95, P9, DOI 10.1016/S0169-328X(01)00165-6 | - |
hcfmusp.relation.reference | VONDERHAAR BK, 1979, ENDOCRINOLOGY, V104, P409 | - |
hcfmusp.relation.reference | VORHERR H, 1987, EUR J CANCER CLIN ON, V23, P255, DOI 10.1016/0277-5379(87)90066-6 | - |
hcfmusp.relation.reference | Weiss HA, 1999, INT J EPIDEMIOL, V28, P816, DOI 10.1093/ije/28.5.816 | - |
dc.description.index | MEDLINE | - |
hcfmusp.lim.ref | 2012 | - |
hcfmusp.citation.scopus | 1 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MDR Artigos e Materiais de Revistas Científicas - LIM/24 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_BRENTANI_Thyroid_hormone_profile_in_breast_cancer_patients_in_2012.PDF | publishedVersion (Portuguese) | 118.79 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.