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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorFLORES, Gustavo-
dc.contributor.authorCULTON, Donna A.-
dc.contributor.authorPRISAYANH, Phillip-
dc.contributor.authorQAQISH, Bahjat F.-
dc.contributor.authorJAMES, Kirk-
dc.contributor.authorMALDONADO, Mike-
dc.contributor.authorAOKI, Valeria-
dc.contributor.authorHANS-FILHO, Gunter-
dc.contributor.authorRIVITTI, Evandro A.-
dc.contributor.authorDIAZ, Luis A.-
dc.identifier.citationJOURNAL OF INVESTIGATIVE DERMATOLOGY, v.132, n.11, p.2573-2580, 2012-
dc.description.abstractIt is well established that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of pemphigus vulgaris and pemphigus foliaceus, including its endemic form fogo selvagem (FS). Isolated reports have shown that in certain patients with these diseases, autoantibodies against other desmosomal cadherins and E-cadherin may also be present. The goal of this investigation was to determine whether FS patients and normal individuals living in endemic areas possess autoantibodies against other desmosomal cadherins and E-cadherin. By testing a large number of FS and endemic control sera by ELISA, we found a consistent and specific autoantibody response against Dsg1 and other keratinocyte cadherins in these individuals, which is quite different from healthy individuals from the United States (US controls). Overall, the highest correlations among the autoantibody responses tested were in the endemic controls, followed by FS patients, and lowest in the US controls. These findings suggest that multiple, perhaps cross-reactive, keratinocyte cadherins are recognized by FS patients and endemic controls.-
dc.description.sponsorshipNational Institutes of Health (NIH) [R01-AR30281, R01-AR32599, T32-AR07369]-
dc.relation.ispartofJournal of Investigative Dermatology-
dc.subject.otherbrazilian pemphigus-
dc.subject.otherdesmoglein 1-
dc.titleIgG Autoantibody Response against Keratinocyte Cadherins in Endemic Pemphigus Foliaceus (Fogo Selvagem)-
dc.rights.holderCopyright NATURE PUBLISHING GROUP-
dc.contributor.groupauthorCooperative Grp Fogo Selvagem Res-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Gustavo:Univ N Carolina, Dept Dermatol, Chapel Hill, NC 27599 USA-, Donna A.:Univ N Carolina, Dept Dermatol, Chapel Hill, NC 27599 USA-, Phillip:Univ N Carolina, Dept Dermatol, Chapel Hill, NC 27599 USA-, Bahjat F.:Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA-, Kirk:Univ N Carolina, Dept Dermatol, Chapel Hill, NC 27599 USA-, Mike:Univ N Carolina, Dept Dermatol, Chapel Hill, NC 27599 USA-, Gunter:Univ Fed Mato Grosso do Sul, Dept Dermatol, Campo Grande, Brazil-, Luis A.:Univ N Carolina, Dept Dermatol, Chapel Hill, NC 27599 USA-
hcfmusp.publisher.cityNEW YORK-
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Artigos e Materiais de Revistas Científicas - FM/MDT
Departamento de Dermatologia - FM/MDT

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/56
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências

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