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Title: Multiple endocrine neoplasia type 1 presenting as refractory epilepsy and polyneuropathy - A case report
Authors: PAIVA, Anderson Rodrigues Brandao deCASTRO, Luiz Henrique MartinsRODRIGUES JR., WaldyrPASSARELLI, ValmirJORGE, Carmen LisaBROTTO, Mario Wilson I.HIRATA, Maria Teresa AlvesMARCHIORI, Paulo Euripedes
Citation: JOURNAL OF THE NEUROLOGICAL SCIENCES, v.315, n.1-2, p.172-175, 2012
Abstract: Hypoglycemia is a well recognized cause of acute symptomatic seizures. The fact that hypoglycemia can cause peripheral neuropathy is less appreciated. We describe a case of insulinoma associated peripheral neuropathy. A 17 year-old previously healthy man was referred for investigation of refractory epilepsy. A history of recurrent seizures, slowly progressive weakness of his feet and hands, and weight gain was obtained. Physical examination showed signs of a chronic sensory-motor polyneuropathy. He was diagnosed with insulinoma and primary hyperparathyroidism, characterizing multiple endocrine neoplasia, type 1 syndrome. Cases of insulinoma associated peripheral neuropathy are very rare. The more characteristic clinical picture appears to be distal weakness, worse in the intrinsic hand and feet muscles, and no or mild sensory signs. Peripheral nervous system symptoms may not completely resolve, despite removal of the cause of hyperinsulinism/hypoglycemia and full reversion of central nervous system symptoms. Mechanisms underlying hypoglycemic neuropathy are still poorly understood.
Appears in Collections:Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/15
Artigos e Materiais de Revistas Científicas - LIM/45

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