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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | SESSO, A. | - |
dc.contributor.author | BELIZARIO, J. E. | - |
dc.contributor.author | MARQUES, M. M. | - |
dc.contributor.author | HIGUCHI, M. L. | - |
dc.contributor.author | SCHUMACHER, R. I. | - |
dc.contributor.author | COLQUHOUN, A. | - |
dc.contributor.author | ITO, E. | - |
dc.contributor.author | KAWAKAMI, J. | - |
dc.date.accessioned | 2013-10-02T19:32:06Z | - |
dc.date.available | 2013-10-02T19:32:06Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, v.295, n.10, p.1647-1659, 2012 | - |
dc.identifier.issn | 1932-8486 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/2572 | - |
dc.description.abstract | Outer mitochondrial membrane (OMM) rupture was first noted in isolated mitochondria in which the inner mitochondrial membrane (IMM) had lost its selective permeability. This phenomenon referred to as mitochondrial permeability transition (MPT) refers to a permeabilized inner membrane that originates a large swelling in the mitochondrial matrix, which distends the outer membrane until it ruptures. Here, we have expanded previous electron microscopic observations that in apoptotic cells, OMM rupture is not caused by a membrane stretching promoted by a markedly swollen matrix. It is shown that the widths of the ruptured regions of the OMM vary from 6 to 250 nm. Independent of the perforation size, herniation of the mitochondrial matrix appeared to have resulted in pushing the IMM through the perforation. A large, long focal herniation of the mitochondrial matrix, covered with the IMM, was associated with a rupture of the OMM that was as small as 6 nm. Contextually, the collapse of the selective permeability of the IMM may precede or follow the release of the mitochondrial proteins of the intermembrane space into the cytoplasm. When the MPT is a late event, exit of the intermembrane space proteins to the cytoplasm is unimpeded and occurs through channels that transverse the outer membrane, because so far, the inner membrane is impermeable. No channel within the outer membrane can expose to the cytoplasm a permeable inner membrane, because it would serve as a conduit for local herniation of the mitochondrial matrix. Anat Rec, 2012. (c) 2012 Wiley Periodicals, Inc. | - |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, FAPESP [00/06648-2] | - |
dc.description.sponsorship | Conselho Nacional de Pesquisas, CNPq [Processo 520359/1996-8 e, Processo 472208/2004-7] | - |
dc.language.iso | eng | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.ispartof | Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology | - |
dc.rights | restrictedAccess | - |
dc.subject | electron microscopy | - |
dc.subject | mitochondria | - |
dc.subject | apoptosis | - |
dc.subject | rupture of the outer mitochondrial membrane | - |
dc.subject | focal matrix herniation in mitochondria | - |
dc.subject | inner mitochondrial membrane | - |
dc.subject | mitochondrial outer membrane permeabilization | - |
dc.subject | mitochondrial proteins of the intermembrane space | - |
dc.subject | mitochon-drial permeability transition | - |
dc.subject | outer mitochon-drial membrane | - |
dc.subject.other | permeability transition pore | - |
dc.subject.other | cytochrome-c release | - |
dc.subject.other | delta-psi-m | - |
dc.subject.other | oxidative stress | - |
dc.subject.other | epithelial-cells | - |
dc.subject.other | death | - |
dc.subject.other | proteins | - |
dc.subject.other | bax | - |
dc.subject.other | p53 | - |
dc.subject.other | ultrastructure | - |
dc.title | Mitochondrial Swelling and Incipient Outer Membrane Rupture in Preapoptotic and Apoptotic Cells | - |
dc.type | article | - |
dc.rights.holder | Copyright WILEY-BLACKWELL | - |
dc.identifier.doi | 10.1002/ar.22553 | - |
dc.identifier.pmid | 22907871 | - |
dc.subject.wos | Anatomy & Morphology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | BELIZARIO, J. E.:Univ Sao Paulo, Dept Farmacol, Inst Ciencias Biomed, BR-05403000 Sao Paulo, Brazil | - |
hcfmusp.author.external | MARQUES, M. M.:Univ Sao Paulo, Dept Dent, Fac Odontol, BR-05403000 Sao Paulo, Brazil | - |
hcfmusp.author.external | SCHUMACHER, R. I.:Univ Sao Paulo, Dept Bioquim, Inst Quim, BR-05403000 Sao Paulo, Brazil | - |
hcfmusp.author.external | COLQUHOUN, A.:Univ Sao Paulo, Dept Histol, Inst Ciencias Biomed, BR-05403000 Sao Paulo, Brazil | - |
hcfmusp.author.external | ITO, E.:Univ Sao Paulo, Setor Biol Estrutural, Lab Imunopatol, Inst Trop Med, BR-05403000 Sao Paulo, Brazil | - |
hcfmusp.description.beginpage | 1647 | - |
hcfmusp.description.endpage | 1659 | - |
hcfmusp.description.issue | 10 | - |
hcfmusp.description.volume | 295 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84866156089 | - |
hcfmusp.origem.id | WOS:000308638600014 | - |
hcfmusp.publisher.city | HOBOKEN | - |
hcfmusp.publisher.country | USA | - |
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dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | CNPq | - |
hcfmusp.remissive.sponsorship | FAPESP | - |
hcfmusp.citation.scopus | 56 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/06 |
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