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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | GOIS, Pedro Henrique Franca | - |
dc.contributor.author | MARTINES, Monique Silva | - |
dc.contributor.author | FERREIRA, Daniela | - |
dc.contributor.author | VOLPINI, Rildo | - |
dc.contributor.author | CANALE, Daniele | - |
dc.contributor.author | MALAQUE, Ceila | - |
dc.contributor.author | CRAJOINAS, Renato | - |
dc.contributor.author | GIRARDI, Adriana Castello Costa | - |
dc.contributor.author | SHIMIZU, Maria Heloisa Massola | - |
dc.contributor.author | SEGURO, Antonio Carlos | - |
dc.date.accessioned | 2018-03-06T15:21:12Z | - |
dc.date.available | 2018-03-06T15:21:12Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | PLOS NEGLECTED TROPICAL DISEASES, v.11, n.11, article ID e0006024, 15p, 2017 | - |
dc.identifier.issn | 1935-2735 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/25744 | - |
dc.description.abstract | Snakebites have been recognized as a neglected public health problem in several tropical and subtropical countries. Bothrops snakebites frequently complicate with acute kidney injury (AKI) with relevant morbidity and mortality. To date, the only treatment available for Bothrops envenomation is the intravenous administration of antivenom despite its several limitations. Therefore, the study of novel therapies in Bothrops envenomation is compelling. The aim of this study was to evaluate the protective effect of Allopurinol (Allo) in an experimental model of Bothrops jararaca venom (BJ)-associated AKI. Five groups of Wistar rats were studied: Sham, Allo, BJ, BJ+Allo, BJ+ipAllo. BJ (0.25 mg/kg) was intravenously injected during 40'. Saline at same dose and infusion rate was administered to Sham and Allo groups. Allo and BJ+Allo groups received Allo (300 mg/L) in the drinking water 7 days prior to Saline or BJ infusion respectively. BJ+ipAllo rats received intraperitoneal Allo (25 mg/Kg) 40' after BJ infusion. BJ rats showed markedly reduced glomerular filtration rate (GFR, inulin clearance) associated with intense renal vasoconstriction, hemolysis, hemoglobinuria, reduced glutathione and increased systemic and renal markers of nitro-oxidative stress (Nitrotyrosine). Allo ameliorated GFR, renal blood flow (RBF), renal vascular resistance and arterial lactate levels. In addition, Allo was associated with increased serum glutathione as well as reduced levels of plasma and renal Nitrotyrosine. Our data show that Allo attenuated BJ-associated AKI, reduced oxidative stress, improved renal hemodynamics and organ perfusion. It might represent a novel adjuvant approach for Bothrops envenomation, a new use for an old and widely available drug. | - |
dc.description.sponsorship | National Council for Scientific and Technological Development (CNPq) [306148/2013-7] | - |
dc.description.sponsorship | Sao Paulo Research Foundation (FAPESP) [2015/11933-3] | - |
dc.language.iso | eng | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.relation.ispartof | Plos Neglected Tropical Diseases | - |
dc.rights | openAccess | - |
dc.subject.other | oxidative stress | - |
dc.subject.other | uric-acid | - |
dc.subject.other | snake-venom | - |
dc.subject.other | experimental-model | - |
dc.subject.other | hemorrhagic-shock | - |
dc.subject.other | renal-failure | - |
dc.subject.other | bites | - |
dc.subject.other | hyperuricemia | - |
dc.subject.other | pretreatment | - |
dc.subject.other | reperfusion | - |
dc.title | Allopurinol attenuates acute kidney injury following Bothrops jararaca envenomation | - |
dc.type | article | - |
dc.rights.holder | Copyright PUBLIC LIBRARY SCIENCE | - |
dc.identifier.doi | 10.1371/journal.pntd.0006024 | - |
dc.identifier.pmid | 29155815 | - |
dc.subject.wos | Infectious Diseases | - |
dc.subject.wos | Parasitology | - |
dc.subject.wos | Tropical Medicine | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | MARTINES, Monique Silva:Univ Sao Paulo, Sch Med, Nephrol Dept, Lab Med Res LIM12, Sao Paulo, Brazil | - |
hcfmusp.author.external | FERREIRA, Daniela:Univ Sao Paulo, Sch Med, Nephrol Dept, Lab Med Res LIM12, Sao Paulo, Brazil | - |
hcfmusp.author.external | MALAQUE, Ceila:Vital Brazil Hosp, Butantan Inst, Sao Paulo, Brazil | - |
hcfmusp.description.articlenumber | e0006024 | - |
hcfmusp.description.issue | 11 | - |
hcfmusp.description.volume | 11 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-85036662824 | - |
hcfmusp.origem.id | WOS:000416832800017 | - |
hcfmusp.publisher.city | SAN FRANCISCO | - |
hcfmusp.publisher.country | USA | - |
hcfmusp.relation.reference | Alape-Giron A, 2008, J PROTEOME RES, V7, P3556, DOI 10.1021/pr800332p | - |
hcfmusp.relation.reference | ALLAN G, 1986, BRIT J PHARMACOL, V89, P149, DOI 10.1111/j.1476-5381.1986.tb11130.x | - |
hcfmusp.relation.reference | AMARAL CFS, 1985, TOXICON, V23, P877, DOI 10.1016/0041-0101(85)90379-4 | - |
hcfmusp.relation.reference | Badr KF, 2005, ANTIOXID REDOX SIGN, V7, P236, DOI 10.1089/ars.2005.7.236 | - |
hcfmusp.relation.reference | Boer-Lima PA, 1999, AM J TROP MED HYG, V61, P698, DOI 10.4269/ajtmh.1999.61.698 | - |
hcfmusp.relation.reference | Brown NI, 2012, PLOS NEGLECT TROP D, V6, DOI 10.1371/journal.pntd.0001670 | - |
hcfmusp.relation.reference | BURDMANN EA, 1993, AM J TROP MED HYG, V48, P82, DOI 10.4269/ajtmh.1993.48.82 | - |
hcfmusp.relation.reference | Calvete JJ, 2011, J PROTEOMICS, V74, P510, DOI 10.1016/j.jprot.2011.01.003 | - |
hcfmusp.relation.reference | Cardoso J. L. C., 2009, ANIMAIS PECONHENTOS | - |
hcfmusp.relation.reference | CASTELLI P, 1995, J CARDIOVASC PHARM, V25, P119, DOI 10.1097/00005344-199501000-00019 | - |
hcfmusp.relation.reference | CHAVES F, 1995, TOXICON, V33, P31, DOI 10.1016/0041-0101(94)00135-U | - |
hcfmusp.relation.reference | Chippaux JP, 1998, B WORLD HEALTH ORGAN, V76, P515 | - |
hcfmusp.relation.reference | CUNNINGHAM SK, 1978, EUR SURG RES, V10, P305, DOI 10.1159/000128020 | - |
hcfmusp.relation.reference | de Castroa I, 2004, TOXICON, V43, P833, DOI 10.1016/j.toxicon.2004.03.015 | - |
hcfmusp.relation.reference | Doley R, 2009, CELL MOL LIFE SCI, V66, P2851, DOI 10.1007/s00018-009-0050-2 | - |
hcfmusp.relation.reference | Erol T, 2013, INT J CARDIOL, V167, P1396, DOI 10.1016/j.ijcard.2012.04.068 | - |
hcfmusp.relation.reference | Feig DI, 2006, J AM SOC NEPHROL, V17, pS69, DOI 10.1681/ASN.2005121331 | - |
hcfmusp.relation.reference | Gois PHF, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008652.pub3 | - |
hcfmusp.relation.reference | Gasparovic AC, 2017, BRIT J PHARMACOL, V174, P1771, DOI 10.1111/bph.13673 | - |
hcfmusp.relation.reference | Gois PHF, 2016, FREE RADIC BIOL MED, P101 | - |
hcfmusp.relation.reference | Goncalves-Machado L, 2016, J PROTEOMICS, V135, P73, DOI 10.1016/j.jprot.2015.04.029 | - |
hcfmusp.relation.reference | Guan WP, 2003, J CARDIOVASC PHARM, V41, P699, DOI 10.1097/00005344-200305000-00005 | - |
hcfmusp.relation.reference | Gutierrez JM, 2006, PLOS MED, V3, P727, DOI 10.1371/journal.pmed.0030150 | - |
hcfmusp.relation.reference | Gutierrez Jose Maria, 2011, Inflammation & Allergy Drug Targets, V10, P369 | - |
hcfmusp.relation.reference | Harrison RA, 2009, PLOS NEGLECT TROP D, V3, DOI 10.1371/journal.pntd.0000569 | - |
hcfmusp.relation.reference | Johnson RJ, 2013, NEPHROL DIAL TRANSPL, V28, P2221, DOI 10.1093/ndt/gft029 | - |
hcfmusp.relation.reference | Kasturiratne A, 2008, PLOS MED, V5, P1591, DOI 10.1371/journal.pmed.0050218 | - |
hcfmusp.relation.reference | Keel CE, 2013, UROLOGY, V81, DOI 10.1016/j.urology.2012.08.016 | - |
hcfmusp.relation.reference | Khosla UM, 2005, KIDNEY INT, V67, P1739, DOI 10.1111/j.1523-1755.2005.00273.x | - |
hcfmusp.relation.reference | Kossmann S, 2014, J BIOL CHEM, V289, P27540, DOI 10.1074/jbc.M114.604231 | - |
hcfmusp.relation.reference | Legrand M, 2008, MOL MED, V14, P502, DOI 10.2119/2008-00006.Legrand | - |
hcfmusp.relation.reference | Gutierrez JM, 2010, J PROTEOME RES, V9, P564, DOI 10.1021/pr9009518 | - |
hcfmusp.relation.reference | Gutierrez JM, 2009, TOXICON, V54, P976, DOI 10.1016/j.toxicon.2009.01.039 | - |
hcfmusp.relation.reference | Martines MS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086828 | - |
hcfmusp.relation.reference | Mazzali M, 2001, HYPERTENSION, V38, P1101, DOI 10.1161/hy1101.092839 | - |
hcfmusp.relation.reference | MEISTER A, 1983, ANNU REV BIOCHEM, V52, P711, DOI 10.1146/annurev.bi.52.070183.003431 | - |
hcfmusp.relation.reference | Moore KP, 1998, J BIOL CHEM, V273, P31731, DOI 10.1074/jbc.273.48.31731 | - |
hcfmusp.relation.reference | Nunez V, 2009, J PROTEOMICS, V73, P57, DOI 10.1016/j.jprot.2009.07.013 | - |
hcfmusp.relation.reference | Otero-Patino R, 2009, TOXICON, V54, P998, DOI 10.1016/j.toxicon.2009.07.001 | - |
hcfmusp.relation.reference | Pacher P, 2006, PHARMACOL REV, V58, P87, DOI 10.1124/pr.58.1.6 | - |
hcfmusp.relation.reference | Ribeiro LA, REV I MED TROP SAO P, V32, P436 | - |
hcfmusp.relation.reference | Rodrigues RS, 2009, BIOCHIMIE, V91, P490, DOI 10.1016/j.biochi.2008.12.004 | - |
hcfmusp.relation.reference | Sanchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V295, pF1134, DOI 10.1152/ajprenal.00104.2008 | - |
hcfmusp.relation.reference | Santhosh MS, 2013, J THROMB THROMBOLYS, V36, P424, DOI 10.1007/s11239-013-0888-x | - |
hcfmusp.relation.reference | Santos CXC, 1999, ARCH BIOCHEM BIOPHYS, V372, P285, DOI 10.1006/abbi.1999.1491 | - |
hcfmusp.relation.reference | Sapalidis Konstantinos, 2013, J Emerg Trauma Shock, V6, P203, DOI 10.4103/0974-2700.115346 | - |
hcfmusp.relation.reference | Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006 | - |
hcfmusp.relation.reference | SEDLAK J, 1968, ANAL BIOCHEM, V25, P192, DOI 10.1016/0003-2697(68)90092-4 | - |
hcfmusp.relation.reference | Sgrignolli LR, 2011, NEPHRON CLIN PRACT, V119, pC131, DOI 10.1159/000324228 | - |
hcfmusp.relation.reference | Sharma V, 2009, BRIT J PHARMACOL, V157, P907, DOI 10.1111/j.1476-5381.2009.00267.x | - |
hcfmusp.relation.reference | Strapazzon JD, 2015, J APPL BIOMED, V13, P161, DOI 10.1016/j.jab.2014.11.002 | - |
hcfmusp.relation.reference | Sunitha K, 2015, TOXICON, V98, P89, DOI 10.1016/j.toxicon.2015.02.014 | - |
hcfmusp.relation.reference | TAN NH, 1991, COMP BIOCHEM PHYS B, V100, P361, DOI 10.1016/0305-0491(91)90387-S | - |
hcfmusp.relation.reference | Tanabe K, 2014, J CARDIOL, V64, P86, DOI 10.1016/j.jjcc.2013.11.017 | - |
hcfmusp.relation.reference | Walker LM, 2001, TOXICOL SCI, V63, P143, DOI 10.1093/toxsci/63.1.143 | - |
hcfmusp.relation.reference | Wayenberg JL, 2009, FREE RADICAL BIO MED, V47, P975, DOI 10.1016/j.freeradbiomed.2009.07.003 | - |
hcfmusp.relation.reference | Weston RE, 1943, AM J PHYSIOL, V138, P0450 | - |
hcfmusp.relation.reference | Williams DJ, 2011, J PROTEOMICS, V74, P1735, DOI 10.1016/j.jprot.2011.05.027 | - |
hcfmusp.relation.reference | Zengin S, 2014, EMERG MED J, V31, P48, DOI 10.1136/emermed-2012-202013 | - |
dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 10 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
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