MAIT cells are activated in acute Dengue virus infection and after in vitro Zika virus infection

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP PAQUIN-PROULX, Dominic
BARSOTTI, Nathalia Silveira
SIROMA, Fabiana
RAMOS, Jessica Fernandes FMUSP-HC
TONACIO, Adriana Coracini FMUSP-HC
FELIX, Alvina Clara FMUSP-HC
LEVI, Jose Eduardo FMUSP-HC
GREENSPUN, Benjamin C.
ROUGVIE, Miguel de Mulder
NIXON, Douglas F.
KALLAS, Esper G. FMUSP-HC 2018
dc.identifier.citation PLOS NEGLECTED TROPICAL DISEASES, v.12, n.1, article ID e0006154, 15p, 2018
dc.identifier.issn 1935-2735
dc.description.abstract Dengue virus (DENV) and Zika virus (ZIKV) are members of the Flaviviridae and are pre-dominantly transmitted via mosquito bites. Both viruses are responsible for a growing number of infections in tropical and subtropical regions. DENV infection can cause lethargy with severe morbidity and dengue shock syndrome leading to death in some cases. ZIKV is now linked with Guillain-Barre A syndrome and fetal malformations including microcephaly and developmental disorders (congenital Zika syndrome). The protective and pathogenic roles played by the immune response in these infections is unknown. Mucosal-associated invariant T (MAIT) cells are a population of innate T cells with potent anti-bacterial activity. MAIT cells have also been postulated to play a role in the immune response to viral infections. In this study, we evaluated MAIT cell frequency, phenotype, and function in samples from subjects with acute and convalescent DENV infection. We found that in acute DENV infection, MAIT cells had elevated co-expression of the activation markers CD38 and HLA-DR and had a poor IFN gamma response following bacterial stimulation. Furthermore, we found that MAIT cells can produce IFN gamma in response to in vitro infection with ZIKV. This MAIT cell response was independent of MR1, but dependent on IL-12 and IL-18. Our results suggest that MAIT cells may play an important role in the immune response to Flavivirus infections.
dc.description.sponsorship · District of Columbia Center for AIDS Research, an NIH [AI117970]
· GWU SMHS Office of International Medicine Programs
dc.language.iso eng
dc.relation.ispartof Plos Neglected Tropical Diseases
dc.rights openAccess
dc.subject.other invariant t-cells; hemorrhagic-fever; hiv-infection; mr1; transmission; population; immunity
dc.title MAIT cells are activated in acute Dengue virus infection and after in vitro Zika virus infection
dc.type article
dc.rights.holder Copyright PUBLIC LIBRARY SCIENCE LIM/37 LIM/49 LIM/52 LIM/54 LIM/60
dc.identifier.doi 10.1371/journal.pntd.0006154
dc.identifier.pmid 29357366
dc.type.category original article
dc.type.version publishedVersion AVELINO-SILVA, Vivian I.:HC:ICHC SANTOS, Bianca A. N.:FM: RAMOS, Jessica Fernandes:HC:ICHC TONACIO, Adriana Coracini:HC:ICHC SONG, Alice:HC:ICHC MAESTRI, Alvino:HC:ICHC CERQUEIRA, Natalia Barros:FM: FELIX, Alvina Clara:IMT:SCVIRO-83 LEVI, Jose Eduardo:IMT: KALLAS, Esper G.:FM:MCM · PAQUIN-PROULX, Dominic:George Washington Univ, Dept Microbiol Immunol & Trop Med, Washington, DC 20052 USA
· BARSOTTI, Nathalia Silveira:Univ Sao Paulo, Sch Med, Sao Paulo, Brazil
· SIROMA, Fabiana:Hosp Sirio Libanes, Sao Paulo, Brazil
· GREENSPUN, Benjamin C.:George Washington Univ, Dept Microbiol Immunol & Trop Med, Washington, DC 20052 USA
· ROUGVIE, Miguel de Mulder:George Washington Univ, Dept Microbiol Immunol & Trop Med, Washington, DC 20052 USA
· ROSENBERG, Michael G.:Jacobi Med Ctr, Pediat Infect Dis Dept, Bronx, NY USA
· NIXON, Douglas F.:George Washington Univ, Dept Microbiol Immunol & Trop Med, Washington, DC 20052 USA WOS:000424022700027 2-s2.0-85041703525 SAN FRANCISCO USA
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dc.description.index MEDLINE
hcfmusp.citation.scopus 23 Brasil Estados Unidos
hcfmusp.scopus.lastupdate 2021-07-13

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