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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBERMUDES, Ana Carolina G.
dc.contributor.authorCARVALHO, Werther B. de
dc.contributor.authorZAMBERLAN, Patricia
dc.contributor.authorMURAMOTO, Giovana
dc.contributor.authorMARANHAO, Raul C.
dc.contributor.authorDELGADO, Artur F.
dc.identifier.citationNUTRITION, v.47, p.104-109, 2018
dc.description.abstractObjectives: Limited knowledge exists regarding the lipid profiles of critically ill pediatric patients with systemic inflammatory response syndrome. The aim of this study was to evaluate the relationship between the intensity of the inflammatory response and changes in the lipid profiles of critically ill pediatric patients admitted to a pediatric intensive care unit (PICU) with severe sepsis/septic shock. Methods: This was a prospective and observational study at a 15-bed PICU at a public university hospital. We analyzed the lipid profiles of 40 patients with severe sepsis/septic shock admitted to the PICU on the first and seventh days of hospitalization. C-reactive protein was used as a marker for systemic inflammation. Forty-two pediatric patients seen in the emergency department and without systemic inflammatory response syndrome were used to provide control values. Results: On day 1 of admission to the PICU, the patients had significantly lower levels of total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) as well as higher concentrations of triacylglycerols compared with the control group. There was a significant increase in the TC, HDL, LDL, and apolipoprotein levels from day 1 to day 7 of the study. Conclusions: During severe sepsis/septic shock, we found lower serum levels of lipoproteins and apolipoproteins, and these were negatively correlated with C-reactive protein. As the inflammatory response improved, the levels of TC, HDL, LDL, and apolipoproteins increased, suggesting a direct relationship between changes in the lipid profiles and inflammation.
dc.subjectLipid metabolism
dc.subjectIntensive care units
dc.subject.othersystemic inflammatory response
dc.subject.otherhospital malnutrition
dc.subject.othercritical illness
dc.subject.otherorgan failure
dc.titleChanges in lipid metabolism in pediatric patients with severe sepsis and septic shock
dc.rights.holderCopyright ELSEVIER SCIENCE INC
dc.subject.wosNutrition & Dietetics
dc.type.categoryoriginal article
dc.type.versionpublishedVersion, Giovana:Univ Sao Paulo, Hosp Univ, Emergency Dept, Sao Paulo, Brazil
hcfmusp.publisher.cityNEW YORK
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Artigos e Materiais de Revistas Científicas - FM/MPE
Departamento de Pediatria - FM/MPE

Artigos e Materiais de Revistas Científicas - HC/ICr
Instituto da Criança - HC/ICr

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/31
LIM/31 - Laboratório de Genética e Hematologia Molecular

Artigos e Materiais de Revistas Científicas - LIM/36
LIM/36 - Laboratório de Pediatria Clínica

Artigos e Materiais de Revistas Científicas - ODS/02
ODS/02 - Fome zero e agricultura sustentável

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