Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/26385
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBERMUDES, Ana Carolina G.
dc.contributor.authorCARVALHO, Werther B. de
dc.contributor.authorZAMBERLAN, Patricia
dc.contributor.authorMURAMOTO, Giovana
dc.contributor.authorMARANHAO, Raul C.
dc.contributor.authorDELGADO, Artur F.
dc.date.accessioned2018-05-08T14:35:30Z
dc.date.available2018-05-08T14:35:30Z
dc.date.issued2018
dc.identifier.citationNUTRITION, v.47, p.104-109, 2018
dc.identifier.issn0899-9007
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/26385
dc.description.abstractObjectives: Limited knowledge exists regarding the lipid profiles of critically ill pediatric patients with systemic inflammatory response syndrome. The aim of this study was to evaluate the relationship between the intensity of the inflammatory response and changes in the lipid profiles of critically ill pediatric patients admitted to a pediatric intensive care unit (PICU) with severe sepsis/septic shock. Methods: This was a prospective and observational study at a 15-bed PICU at a public university hospital. We analyzed the lipid profiles of 40 patients with severe sepsis/septic shock admitted to the PICU on the first and seventh days of hospitalization. C-reactive protein was used as a marker for systemic inflammation. Forty-two pediatric patients seen in the emergency department and without systemic inflammatory response syndrome were used to provide control values. Results: On day 1 of admission to the PICU, the patients had significantly lower levels of total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) as well as higher concentrations of triacylglycerols compared with the control group. There was a significant increase in the TC, HDL, LDL, and apolipoprotein levels from day 1 to day 7 of the study. Conclusions: During severe sepsis/septic shock, we found lower serum levels of lipoproteins and apolipoproteins, and these were negatively correlated with C-reactive protein. As the inflammatory response improved, the levels of TC, HDL, LDL, and apolipoproteins increased, suggesting a direct relationship between changes in the lipid profiles and inflammation.
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofNutrition
dc.rightsrestrictedAccess
dc.subjectLipid metabolism
dc.subjectIntensive care units
dc.subjectPediatric
dc.subjectSepsis
dc.subjectLipoproteins
dc.subjectMalnutrition
dc.subject.othersystemic inflammatory response
dc.subject.otherhigh-density-lipoproteins
dc.subject.otherintensive-care-unit
dc.subject.otherapolipoprotein-a-i
dc.subject.otherhospital malnutrition
dc.subject.othercritical illness
dc.subject.otherorgan failure
dc.subject.othercholesterol
dc.subject.othernutrition
dc.subject.otherchildren
dc.titleChanges in lipid metabolism in pediatric patients with severe sepsis and septic shock
dc.typearticle
dc.rights.holderCopyright ELSEVIER SCIENCE INC
dc.identifier.doi10.1016/j.nut.2017.09.015
dc.identifier.pmid29429528
dc.subject.wosNutrition & Dietetics
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
hcfmusp.author.externalMURAMOTO, Giovana:Univ Sao Paulo, Hosp Univ, Emergency Dept, Sao Paulo, Brazil
hcfmusp.description.beginpage104
hcfmusp.description.endpage109
hcfmusp.description.volume47
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000426228400017
hcfmusp.origem.id2-s2.0-85044869292
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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dc.description.indexMEDLINE
dc.identifier.eissn1873-1244
hcfmusp.citation.scopus23
hcfmusp.scopus.lastupdate2022-11-18-
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