Use este identificador para citar ou linkar para este item: https://observatorio.fm.usp.br/handle/OPI/2703
Título: Evaluating the atmospheric particulate concentrated carcinogenic potential: a lung cancer experimental study in two different mice models
Autor(es): CURY, P. M.PEDRO, S. S. C.LEMOS, M.PASTRO, L. D. M.JACOMO, A. L.DAGLI, M. L. Z.JUNIOR, E. C. B.SALDIVA, P. H. N.
Parte de: HISTOPATHOLOGY, v.61, suppl.1, Special Issue, p.70-70, 2012
Resumo: Introduction: Previous studies have linked exposure to pollution and cancer, have shown the role of dose-dependent promoters and polluted atmosphere in the progression of lung tumours. Objectives: To determine whether chronic exposure to particulate matter (PM) concentration 2.5, from the ambient air of the city of São Paulo, has carcinogenic potential. Methods: Of the 120 male Swiss and AJ mice, of four to ten weeks of age were exposed daily to the PM 2, 5 in a container, for two hours, for four months. Urethane was used as carcinogen for Swiss mice, in a dose of 3.0 mg/kg, while in the AJ 4 mice, NNK carcinogen was used in a dose of 200 mg/kg. Each strain was divided into four groups: two controls (Cr) containing saline and carcinogen and two exposed (Ex) and saline containing carcinogen. After euthanasia, the lungs were fixed and the number of lesions counted (nodules and hyperplasia). Results: The mean number of lesions in Swiss mice was greater in the exposed group with carcinogen(SWEx-U: 2.57, SD ±2.77) when compared with the control group (SwCr-U: 1.07, SD ±1.54), (P < 0.001) . Similar findings were seen in AJ mice, where the exposed group with NNK (ExNNKAJ: 9.14, SD ±7.70) had more lesions than the non exposed ones (CrNNKAJ : 4.94, SD ±3.54) (P < 0.001). Conclusion: We have evidence that chronic exposure to PM 2, 5 by air pollution in São Paulo has the potential to promote tumors in mice of two different strains.
Aparece nas coleções:

Comunicações em Eventos - FM/MCG
Departamento de Cirurgia - FM/MCG

Comunicações em Eventos - FM/MCM
Departamento de Clínica Médica - FM/MCM

Comunicações em Eventos - FM/MPT
Departamento de Patologia - FM/MPT

Comunicações em Eventos - HC/ICHC
Instituto Central - HC/ICHC

Comunicações em Eventos - HC/InCor
Instituto do Coração - HC/InCor

Comunicações em Eventos - LIM/02
LIM/02 - Laboratório de Anatomia Médico-Cirúrgica

Comunicações em Eventos - LIM/05
LIM/05 - Laboratório de Poluição Atmosférica Experimental

Comunicações em Eventos - LIM/22
LIM/22 - Laboratório de Patolologia Cardiovascular


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