Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/2731
Title: CHROMATOGRAPHIC ANALYSIS OF THE LIPID FRACTIONS IN OBESE CLIENT-OWNED DOGS
Authors: JERICO, M. M.CHIQUITO, F. C.FUSCO, F.CATANOZI, S.NUNES, V. S.NAKANDAKARE, E. R.
Citation: JOURNAL OF VETERINARY INTERNAL MEDICINE, v.26, n.3, p.757-758, 2012
Abstract: Obesity, a metabolic disease of multifactorial origin, impairs the health and longevity of individuals. Dyslipidemia, a common condition in obese animals, is usually associated to a variety of clinical problems, which include gastrointestinal alterations, hepatic lipidosis, atherosclerosis and metabolic syndrome. The aim of the study was to characterize the lipid profile and lipoprotein fractions in obese dogs (n=20) and compare them with control dogs (n=10), selected from a veterinary hospital environment. Lipoproteins (LP) were isolated by fast protein liquid chromatography (FPLC) system and plasma total cholesterol (TC) and triglycerides (TG) concentrations were measured by enzymatic methods. In control group, TC was 193±44 mg/dL (mean±SD) (percentage distribution among LP fractions: VLDL-C 2.34%, LDL-C 15.79%, HDL-C 81.86%); Plasma TG concentration was 50± 15 mg/dL (LP fraction percentage distribution: VLDL-TG 39.17%, LDL-TG 35.9%, HDL-TG 24.94%). In obese dogs, plasma TC was 227± 73 mg/dL (VLDL-C 3,325%, LDL-C21.64%, HDL-C 75.03%) whereas the TG values were 87.9 ± 52 mg/dL (VLDL-TG 61.98%, LDL-TG 24.71%, HDL-TG 13.36%). When compared to the normal dogs, the animals with obesity presented a significant increase (p<0.01) in plasmaTG and VLDL-TG levels as well as a lower HDL-TG concentration. There were not significant alterations in cholesterol fractions or TC between groups although they presented proportionally higher levels of TC, and LDL-C as well as lower HDL-C. It was concluded that obese dogs present a significant difference when compared to normal dogs in relation to triglyceride metabolism and their VLDL and HDL fractions, which has been previously shown in experimental model of obese canine insulin resistance. These findings suggest a higher risk of metabolic complications in obese client-owned dogs, like diabetes, hepatobiliary diseases and o f blood flow disturbances, like atherosclerosis.
Appears in Collections:

Comunicações em Eventos - FM/MCM
Departamento de Clínica Médica - FM/MCM

Comunicações em Eventos - HC/ICHC
Instituto Central - HC/ICHC

Comunicações em Eventos - LIM/10
LIM/10 - Laboratório de Lípides


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