Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/2735
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorCURY, Vivian-
dc.contributor.authorLIMA-SALGADO, Thais-
dc.contributor.authorPINHEIRO, Natalia-
dc.contributor.authorPRADO, Carla Maximo-
dc.contributor.authorASSIS, Livia-
dc.contributor.authorMORETTI, Ana Iochabel-
dc.contributor.authorSOUZA, Heraldo Possolo-
dc.date.accessioned2013-10-11T21:16:41Z-
dc.date.available2013-10-11T21:16:41Z-
dc.date.issued2012-
dc.identifier.citationFASEB JOURNAL, v.26, 2012-
dc.identifier.issn0892-6638-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2735-
dc.description.abstractLow level laser therapy (LLLT) is prescribed as adjuvant therapy for inflammatory diseases. Hence, we examined whether LLLT may ameliorate acute lung injury (ALI) induced by intratracheal LPS instillation. C57 black mice (n=10 per group) were treated with intratracheal LPS (5mg/kg) or PBS. Six hours after instillation, two groups (PBS and LPS) were irradiated with laser at 660 nm, power output 30mW, fluency 10J/cm2. We observed a marked decrease in the number of cells recovered by bronchoalveolar lavage in LPS + LLLT animals compared to LPS alone (2.0±0.8 x 4.4±1.3, respectively p<0.05). LLLT also decreased the number of inflammatory cells infiltrated in lung interstitium (49.6±3.15 x 71.8±3.92), p<0.05). There was also a decrease in the expression of F4/80 (macrophage surface marker) and MCP-1 (monocyte chemoattractant protein-1), detected by quantitative PCR, in animals submitted to LPS + LLLT, when compared to animals that received only LPS. A marked decrease in cytokines secretion (IL1β, TNFα, IL6, IL10) was also observed in LPS+LLLT group. No difference was observed in animals that received PBS, regardless of LLLT. Therefore, LLLT decreases pulmonary inflammatory cell infiltration, cytokines and chemokines secretion in an experimental model of ALI, supporting the notion that laser therapy attenuates inflammatory intensity, what can contribute to accelerate ALI resolution.-
dc.description.sponsorshipNational Counsel of Technological and Scientific Development (CNPq)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.language.isoeng-
dc.publisherFEDERATION AMER SOC EXP BIOL-
dc.relation.ispartofFaseb Journal-
dc.rightsrestrictedAccess-
dc.titleEffect of low level laser therapy on acute lung injury-
dc.typeconferenceObject-
dc.rights.holderCopyright FEDERATION AMER SOC EXP BIOL-
dc.description.conferencedateAPR 21-25, 2012-
dc.description.conferencelocalSan Diego - CA, EUA-
dc.description.conferencenameExperimental Biology Meeting-
dc.subject.wosBiochemistry & Molecular Biology-
dc.subject.wosBiology-
dc.subject.wosCell Biology-
dc.type.categorymeeting abstract-
dc.type.versionpublishedVersion-
hcfmusp.author.externalPRADO, Carla Maximo:Univ Fed Sao Paulo, Biol Sci Dept, Sao Paulo, Brazil-
hcfmusp.author.externalASSIS, Livia:Univ Sao Paulo, Fac Med, Sao Paulo, Brazil-
hcfmusp.description.volume26-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000310711300889-
hcfmusp.publisher.cityBETHESDA-
hcfmusp.publisher.countryUSA-
dc.description.indexMEDLINE-
hcfmusp.remissive.sponsorshipCNPq-
hcfmusp.remissive.sponsorshipFAPESP-
Appears in Collections:

Comunicações em Eventos - FM/MCM
Departamento de Clínica Médica - FM/MCM

Comunicações em Eventos - HC/ICHC
Instituto Central - HC/ICHC

Comunicações em Eventos - LIM/51
LIM/51 - Laboratório de Emergências Clínicas


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