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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorANTUNES-CORREA, Ligia M.-
dc.contributor.authorNOBRE, Thais S.-
dc.contributor.authorGROEHS, Raphaela V.-
dc.contributor.authorALVES, Maria Janieire N. N.-
dc.contributor.authorRONDON, Maria Urbana P. B.-
dc.contributor.authorMADY, Charles-
dc.contributor.authorALMEIDA, Dirceu R.-
dc.contributor.authorOLIVEIRA, Patricia-
dc.contributor.authorLIMA, Marta F.-
dc.contributor.authorMATHIAS, Wilson-
dc.contributor.authorBRUM, Patricia C.-
dc.contributor.authorROSSONI, Luciana V.-
dc.contributor.authorOLIVEIRA, Edilamar M.-
dc.contributor.authorMIDDLEKAUFF, Holly R.-
dc.contributor.authorNEGRAO, Carlos Eduardo-
dc.identifier.citationFASEB JOURNAL, v.27, 2013-
dc.description.abstractIncreased sympathetic muscle mechanoreflex sensitivity and attenuated sympathetic muscle metaboreflex sensitivity have been described in heart failure (HF) patients. We tested the hypothesis that exercise training (ET) would improve sympathetic mechano and metaboreflex sensitivity in HF patients. 24 consecutive, randomized, HF patients, Functional Class II-III NYHA, EF≤40% were divided into two groups: Exercise-trained (n=12, 55±2 years) and untrained (n=12, 54±2 years). 10 normal controls (NC) were also studied. Muscle sympathetic nerve activity (MSNA) was directly recorded from the peroneal nerve. Mechanoreceptors were activated by passive exercise. Metaboreceptors were activated by post-exercise circulatory arrest. ET consisted of three 60-minutes exercise sessions per week for 4 months. ET significantly reduced MSNA in HF patients (34 vs. 40 bursts/min, P<0.05). ET significantly reduced MSNA responses to passive exercise ({Delta} = 2 vs. 5 bursts/min, P<0.05) and increased MNSA responses during post-exercise circulatory arrest ({Delta} = 5 vs. –1 bursts/min, P<0.0 5). These changes were so dramatic that the difference between HF patients and NC were no longer observed. No changes in untrained HF patients were found. In conclusion, ET restores sympathetic muscle mechano and metaboreflex sensitivity in HF patients, which may contribute to the reduction in MSNA and clinical outcomes in these patients.-
dc.relation.ispartofFaseb Journal-
dc.titleExercise Training Restores Muscle Mechano and Metaboreflex Sensitivity in Heart Failure Patients-
dc.rights.holderCopyright FEDERATION AMER SOC EXP BIOL-
dc.description.conferencedateAPR 20-24, 2013-
dc.description.conferencelocalBoston - MA, EUA-
dc.description.conferencenameJoint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)-
dc.subject.wosBiochemistry & Molecular Biology-
dc.subject.wosCell Biology-
dc.type.categorymeeting abstract-
dc.type.versionpublishedVersion-, Maria Urbana P. B.:Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo, Brazil; Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil-, Dirceu R.:Univ Fed Sao Paulo, Dept Med, Sao Paulo, Brazil-, Patricia:Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo, Brazil-, Patricia C.:Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil-, Luciana V.:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil-, Edilamar M.:Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil-, Holly R.:Univ Calif Los Angeles, Dept Med Cardiol & Physiol, Los Angeles, CA USA-
Appears in Collections:

Comunicações em Eventos - FM/MCP
Departamento de Cardio-Pneumologia - FM/MCP

Comunicações em Eventos - HC/InCor
Instituto do Coração - HC/InCor

Comunicações em Eventos - LIM/11
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação

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