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Title: Beta-alanine Supplementation Increases Muscle Carnosine Content And Physical Capacity In Elderly Subjects
Authors: FAVERO, Serena delROSCHEL, HamiltonSOLIS, Marina Y.HAYASHI, Ana P.ARTIOLI, Guilherme G.OTADUY, Maria ConcepcionBENATTI, Fabiana B.HARRIS, Roger C.WISE, John A.LEITE, Claudia C.PEREIRA, Rosa M.SA-PINTO, Ana L. deLANCHA-JUNIOR, Antonio HerbertGUALANO, Bruno
Citation: MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v.44, suppl.2, p.447-447, 2012
Abstract: PURPOSE: To investigate the effects of beta-alanine supplementation on exercise performance capacity and on the muscle carnosine content in elderly subjects. METHODS: Eighteen elderly subjects (65 ± 4 yrs) were randomly assigned to receive either beta-alanine (BA, n=12) or placebo (PL, n=6) for 12 weeks. The BA group received 3.2g of betaalanine per day (2x800mg, given 2 times per day). The PL group received the exact same amount of placebo. At baseline (PRE) and after 12 weeks (POST-12) of supplementation we assessed the muscle carnosine content and anaerobic exercise capacity. Food intake was monitored throughout the study. RESULTS: A significant increase in the muscle carnosine content of the gastrocnemius muscle was found in the BA group (+ 85.4%) when compared with the PL group (+ 7.2%) (p=0.004; ES: 1.21). The time-to-exhaustion in the TLIM test was significantly improved (p=0.05; ES: 1.71) in the BA group (+36.5%) versus the PL group (+8.6%). Similarly, time-to-exhaustion in the incremental test was also significantly increased (p=0.04; ES: 1.03) following beta-alanine supplementation (+12.2%) when compared with placebo (+0.1%). We also observed significant positive correlations between the relative change in the muscle carnosine content and the relative change in the time-to-exhaustion in the TLIM test (r=0.62; p = 0.01) and in the incremental test (r=0.48; p = 0.02). Dietary intake was unchanged. CONCLUSION: beta-alanine supplementation is effective in increasing the muscle carnosine content in healthy elderly subjects, with subsequent improvement in their exercise capacity.
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Comunicações em Eventos - FM/MCM
Departamento de Clínica Médica - FM/MCM

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Departamento de Radiologia - FM/MDR

Comunicações em Eventos - HC/ICHC
Instituto Central - HC/ICHC

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Instituto de Radiologia - HC/InRad

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LIM/17 - Laboratório de Investigação em Reumatologia

Comunicações em Eventos - LIM/44
LIM/44 - Laboratório de Ressonância Magnética em Neurorradiologia

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