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Title: | Beta-alanine Supplementation Increases Muscle Carnosine Content And Physical Capacity In Elderly Subjects |
Authors: | FAVERO, Serena del; ROSCHEL, Hamilton; SOLIS, Marina Y.; HAYASHI, Ana P.; ARTIOLI, Guilherme G.; OTADUY, Maria Concepcion; BENATTI, Fabiana B.; HARRIS, Roger C.; WISE, John A.; LEITE, Claudia C.; PEREIRA, Rosa M.; SA-PINTO, Ana L. de; LANCHA-JUNIOR, Antonio Herbert; GUALANO, Bruno |
Citation: | MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v.44, suppl.2, p.447-447, 2012 |
Abstract: | PURPOSE: To investigate the effects of beta-alanine supplementation on exercise performance capacity and on the muscle carnosine content in elderly subjects. METHODS: Eighteen elderly subjects (65 ± 4 yrs) were randomly assigned to receive either beta-alanine (BA, n=12) or placebo (PL, n=6) for 12 weeks. The BA group received 3.2g of betaalanine per day (2x800mg, given 2 times per day). The PL group received the exact same amount of placebo. At baseline (PRE) and after 12 weeks (POST-12) of supplementation we assessed the muscle carnosine content and anaerobic exercise capacity. Food intake was monitored throughout the study. RESULTS: A significant increase in the muscle carnosine content of the gastrocnemius muscle was found in the BA group (+ 85.4%) when compared with the PL group (+ 7.2%) (p=0.004; ES: 1.21). The time-to-exhaustion in the TLIM test was significantly improved (p=0.05; ES: 1.71) in the BA group (+36.5%) versus the PL group (+8.6%). Similarly, time-to-exhaustion in the incremental test was also significantly increased (p=0.04; ES: 1.03) following beta-alanine supplementation (+12.2%) when compared with placebo (+0.1%). We also observed significant positive correlations between the relative change in the muscle carnosine content and the relative change in the time-to-exhaustion in the TLIM test (r=0.62; p = 0.01) and in the incremental test (r=0.48; p = 0.02). Dietary intake was unchanged. CONCLUSION: beta-alanine supplementation is effective in increasing the muscle carnosine content in healthy elderly subjects, with subsequent improvement in their exercise capacity. |
Appears in Collections: | Comunicações em Eventos - FM/MCM Comunicações em Eventos - FM/MDR Comunicações em Eventos - HC/ICHC Comunicações em Eventos - HC/InRad Comunicações em Eventos - LIM/17 Comunicações em Eventos - LIM/44 |
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