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Title: Endoscopic Suturing Devices and Injection Teraphy on GERD: Prospective Study With Late Follow-Up (60 Months)
Authors: MOURA, Eduardo G. H. DeFERREIRA, Flavio C.SALLUM, Rubens A.NASI, AryOLIVEIRA, Suzana L. DeMOURA, Eduardo T. H. DeMOURA, Diogo T. H. DeSAKAI, PauloCECCONELLO, Ivan
Citation: GASTROINTESTINAL ENDOSCOPY, v.75, n.4, suppl.S, p.473-473, 2012
Abstract: Background: Several studies regarding endoscopic treatment of GERD were published on the 90’s with the intention to reduce gastro-esophageal reflux and diminish the use of acid-suppressing drugs. The appealing immediate results of these therapies that are also minimally invasive characteristics determined our goal to assess the long-term follow up of these patients. Objective: Assess the effectiveness of injection therapy with an inert polymer (G0) and endoscopic plication (G1) on GERD treatment on long-term follow-up (60months). Material: 47 patients with GERD, without complications, with good clinical response to proton pump inhibitors, fit to surgical procedure. Results: Most patients were male on both groups, with median age of 39 y (G0) and 48 y (G1). All patients completed follow-up until 6 months but the analyzes of patients that failed to attend follow-up on 12months and 60 months showed losses of 9,6% and 47,7% for group (G0); 6,9% and 58,7% for group (G1), respectively. It was seen increase over time of patients that had no response (UN) to proton pump inhibitors after 12months on both groups (p<0.001). EAV analyzes showed full response on both groups until 12 months but this was not seen on 60 months follow-up (p=0.013). On 1,3, 6 and 12 months there is a full response of clinical improvement on both groups however on 60 months follow-up it was clear that the number of patients with no response to proton pump inhibitors greatly increased (G0, p=0.019 ; G1 p=0.003). There was no improvement on endoscopic erosive esophagitis score, manometric PRM, total time of acid exposure and DeMeester score. Conclusion: Efficacy of endoscopic plication and injection therapy with inert polimer on GERD was limited on long-term follow-up. There was no sustained clinical response, reduction of proton pump inhibitors, QVSR response, improvement of quality of life, after 12 months. Immediate complications were limited and there was no mortality. There was no improvement of esophagitis score nor esophageal (pH) manometry tests.
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Comunicações em Eventos - FM/MGT
Departamento de Gastroenterologia - FM/MGT

Comunicações em Eventos - HC/ICHC
Instituto Central - HC/ICHC

Comunicações em Eventos - HC/InCor
Instituto do Coração - HC/InCor

Comunicações em Eventos - LIM/35
LIM/35 - Laboratório de Nutrição e Cirurgia Metabólica do Aparelho Digestivo

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