Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/2882
Title: ELASTOGRAPHY AND CONTRAST-ENHANCED ULTRASONOGRAPHY IMPROVES EARLY DETECTION OF HEPATOCELLULAR CARCINOMA IN AN EXPERIMENTAL MODEL OF NON-ALCOHOLIC STEATOHEPATITIS (NASH)
Authors: CARVALHO, C. F.CHAMMAS, M. C.COGLIATTI, B.STEFANO, J. T.CARRILHO, F. J.OLIVEIRA, C. P. M. S.
Citation: JOURNAL OF HEPATOLOGY, v.56, suppl.2, p.S495-S495, 2012
Abstract: Background and Aims: Early detection of focal hepatic lesions is a challenge for ultrasound scanning and becomes even greater in the presence of a diffuse parenchymal disease. Hepatocelular carcinoma is the fifth most common cancer in human being and is a recognized complication of advanced non-alcoholic steatohepatitis. This study aimed to evaluate the diagnostic performance of elastography and contrast-enhanced ultrasonography for early detection of hepatocellular lesions in an experimental model of non-alcoholic steatohepatitis (NASH). Methods: Adult Sprague-Dawley rats, weighing 250–300g, were fed a choline-deficient high fat diet (35% total fat, 54% trans fatty acid enriched) and simultaneously exposed to diethylnitrosamine (13–15mg/day) in drinking water during 16 weeks to induce NASH. Control group (n=10) received standard diet and water ad libitum . B-mode and Doppler ultrasonography was performed weekly in these experimental rats. The animals with NASH that developed focal liver lesions with suggestive malignancy were underwent elastography and contrast-enhanced ultrasonography, euthanized and liver nodules were assessment by histopathology. Tissue stiffness of the nodules on elastography were classified in negative (elastic strain) or positive (hard and no strain) comparing with surrounding liver parenchyma. Contrasted study classified focal lesions according to type of enhancement and wash out. Results: Elastograms of positive lesions showed area of high shear stiffness, which were indicative of malignancy confirmed on histology evaluation, with sensitivity of 100% and specificity of 90%. In the early phase, wash in was significantly associated with malignancy (sensitivity of 71% and specificity of 100%). Also wash out in the late phase was associated with malignancy, with sensitivity of 86% and specificity of 67%. Conclusions: 1. Both techniques allow making right diagnosis with high accuracy of well to moderately-differentiated hepatocellular carcinomas in an experimental model of NASH. 2. Elastography provided promising perspectives for the assessment of malignancy of focal hepatic lesions.
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Comunicações em Eventos - FM/MGT
Departamento de Gastroenterologia - FM/MGT

Comunicações em Eventos - HC/ICHC
Instituto Central - HC/ICHC

Comunicações em Eventos - HC/InRad
Instituto de Radiologia - HC/InRad

Comunicações em Eventos - LIM/07
LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental

Comunicações em Eventos - LIM/44
LIM/44 - Laboratório de Ressonância Magnética em Neurorradiologia


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