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Title: Impact of the severity of end-stage liver disease in cardiac remodeling
Authors: SILVESTRE, Odilson M.BACAL, FernandoRAMOS, DanusaBELLETI, ElisangelaANDRADE, Jose L.PUGLIESE, VincenzoANDRAUS, WellingtonFURTADO, MeiveCARRILHO, Flair J.D'ALBUQUERQUE, Luiz C.FARIAS, Alberto Q.
Citation: HEPATOLOGY, v.56, suppl.1, p.944A-944A, 2012
Abstract: Background: The impact of end-stage liver disease (ESLD) severity in cardiac remodeling of patients with cirrhosis is unknown. Our aim was to correlate the severity of ESLD with morphologic and functional heart changes. Methods: 184 patients underwent a protocol providing data on the severity of ESLD and undergoing echocardiography to assess the diameters of the left atrium and right ventricle; the systolic and diastolic diameters of the left ventricle, interventricular septum, and posterior wall of the left ventricle; systolic pulmonary artery pressure; ejection fraction; and diastolic function. Severity of ESLD was assessed by the Model for End-Stage Liver Disease (MELD) score. Results: Left-atrial diameter (r=0.323; IC 95% 0.190-0.455; p<0.001), left-ventricular diastolic diameter (r=0.177; IC 95% 0.033-0.320; p=0.01) and systolic pulmonary artery pressure (r=0.185; IC 95% 0.036-0.335; p=0.02) significantly correlated with MELD score. Patients with MELD ≥16 had significantly higher left-atrial diameter and systolic pulmonary artery pressure, compared with patients with MELD scores <16 points. Conclusions: Changes in cardiac structure and function, as assessed by echocardiography, correlate with the severity of ESLD in patients with cirrhosis.
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Comunicações em Eventos - FM/MGT
Departamento de Gastroenterologia - FM/MGT

Comunicações em Eventos - HC/ICHC
Instituto Central - HC/ICHC

Comunicações em Eventos - HC/InCor
Instituto do Coração - HC/InCor

Comunicações em Eventos - HC/InRad
Instituto de Radiologia - HC/InRad

Comunicações em Eventos - LIM/07
LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental

Comunicações em Eventos - LIM/11
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação

Comunicações em Eventos - LIM/37
LIM/37 - Laboratório de Transplante e Cirurgia de Fígado

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