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Title: Evaluation of Clinical and Laboratory Response to Influenza and H1N1 Vaccines in a Group of Brazilian CVID Patients
Authors: PEDRESCHI, MairaOLIVEIRA, Ana Karolina BarretoBARROS, Myrthes ToledoCOHON, AndreaCELESTINO, A. T.VILAS-BOAS, L. S.FELIX, A. C.PANNUTI, C. S.KALIL, JorgeKOKRON, Cristina M.
Citation: JOURNAL OF CLINICAL IMMUNOLOGY, v.32, n.2, p.395-395, 2012
Abstract: CVID pts lack vaccine-specific ab production. We studied the clinical / laboratorial responses to influenza and H1N1 immunization in 22 CVID pts. Clinical evaluation was done through a score (infections, hospitalizations, antibiotic use). The score was applied during the previous and following year post immunization (PI). Blood was drawn before and 1/3/6/12 m PI. A significant reduction was observed in upper respiratory infections and sinusitis in the year PI (p<0.001), and 6 pts seroconverted. Statistical analysis showed no difference among ab levels before and PI. Among the 9 pts who presented H1N1 ab production, 4 reduced the clinical score. Of note, 50% of the 22 pts presented reduction of clinical scores. Then, although ab production to H1N1 wasn’t statistically significant, we observed a reduction in the number of infections in the year PI. This observation may be due to eventual presence of influenza’sabs but reinforces potential benefits of vaccination in CVID pts.
Appears in Collections:

Comunicações em Eventos - FM/MCM
Departamento de Clínica Médica - FM/MCM

Comunicações em Eventos - FM/MIP
Departamento de Moléstias Infecciosas e Parasitárias - FM/MIP

Comunicações em Eventos - HC/ICHC
Instituto Central - HC/ICHC

Comunicações em Eventos - HC/InCor
Instituto do Coração - HC/InCor

Comunicações em Eventos - LIM/19
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular

Comunicações em Eventos - LIM/52
LIM/52 - Laboratório de Virologia

Comunicações em Eventos - LIM/60
LIM/60 - Laboratório de Imunologia Clínica e Alergia

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