Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/29318
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorBARROS, Guilherme Garcia-
dc.contributor.authorTANNURI, Ana Cristina Aoun-
dc.contributor.authorROTONDO, Italo Gerardo-
dc.contributor.authorVAISBERG, Vitor Van-
dc.contributor.authorSARMENTO, Leandro Silveira-
dc.contributor.authorNETO, Cicero Mendes-
dc.contributor.authorSERAFINI, Suellen-
dc.contributor.authorGONCALVES, Josiane de Oliveira-
dc.contributor.authorCOELHO, Maria Cecilia Mendonca-
dc.contributor.authorTANNURI, Uenis-
dc.date.accessioned2018-11-21T16:59:15Z-
dc.date.available2018-11-21T16:59:15Z-
dc.date.issued2018-
dc.identifier.citationPEDIATRIC SURGERY INTERNATIONAL, v.34, n.11, p.1215-1224, 2018-
dc.identifier.issn0179-0358-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29318-
dc.description.abstractPurpose To evaluate the role of maintenance of the ileocecal valve (ICV) in intestinal adaptation mechanisms, in a weaning rat experimental model of short bowel. Methods Forty animals were operated on to produce short bowel syndrome. They were divided into five groups: maintenance (MV) or resection of ICV (RV), kill after 4 days (MV4 and RV4) or 21 days (MV21 and RV21), and a control group (21-day-old rats). Body weights, small bowel and colon lengths and diameters, villus heights, crypt depths, lamina propria and muscle layer thickness, as well as the apoptosis index of villi and crypts and expression of pro-and anti-apoptotic genes, were studied. Results Preservation of the ICV promoted increased weight gain (p = 0.0001) and intestinal villus height after 21 days; crypt depth was higher in comparison to controls. It was verified a higher expression of Ki-67 in bowel villi and crypts (p = 0.018 and p = 0.015, respectively) in RV4 group and a higher expression in bowel villi of MV4 group animals (p = 0.03). The maintenance of ICV promoted late increased expression of the anti-apoptotic gene Bcl-XL in the colon (p = 0.043, p = 0.002, p = 0.01). Conclusion The maintenance of the ICV led to positive changes in this model.-
dc.language.isoeng-
dc.publisherSPRINGER-
dc.relation.ispartofPediatric Surgery International-
dc.rightsrestrictedAccess-
dc.subjectBowel resection-
dc.subjectShort bowel syndrome-
dc.subjectIntestine-
dc.subjectNewborn-
dc.subjectParenteral and enteral nutrition-
dc.subjectRat-
dc.subject.otherliver-regeneration-
dc.subject.othercolonic adaptation-
dc.subject.otherenteral autonomy-
dc.subject.otherweanling rats-
dc.subject.otherresection-
dc.subject.otherchildren-
dc.subject.otherexpression-
dc.subject.otherfailure-
dc.subject.otherhepatectomy-
dc.subject.otherpredictors-
dc.titleIs maintenance of the ileocecal valve important to the intestinal adaptation mechanisms in a weaning rat model of short bowel?-
dc.typearticle-
dc.rights.holderCopyright SPRINGER-
dc.identifier.doi10.1007/s00383-018-4333-2-
dc.identifier.pmid30121781
dc.subject.wosPediatrics-
dc.subject.wosSurgery-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalROTONDO, Italo Gerardo:Univ Sao Paulo, Med Sch, Pediat Liver Transplantat Unit, Pediat Surg Div, Sao Paulo, SP, Brazil; Univ Sao Paulo, Med Sch, Lab Res Pediat Surg LIM 30, Sao Paulo, SP, Brazil-
hcfmusp.description.beginpage1215-
hcfmusp.description.endpage1224-
hcfmusp.description.issue11-
hcfmusp.description.volume34-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000447263600013-
hcfmusp.origem.id2-s2.0-85051757375-
hcfmusp.publisher.cityNEW YORK-
hcfmusp.publisher.countryUSA-
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dc.description.indexMEDLINE-
dc.identifier.eissn1437-9813-
hcfmusp.citation.scopus3-
hcfmusp.scopus.lastupdate2022-06-17-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCG
Departamento de Cirurgia - FM/MCG

Artigos e Materiais de Revistas Científicas - FM/MPE
Departamento de Pediatria - FM/MPE

Artigos e Materiais de Revistas Científicas - HC/ICr
Instituto da Criança - HC/ICr

Artigos e Materiais de Revistas Científicas - LIM/07
LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental

Artigos e Materiais de Revistas Científicas - LIM/26
LIM/26 - Laboratório de Pesquisa em Cirurgia Experimental

Artigos e Materiais de Revistas Científicas - LIM/30
LIM/30 - Laboratório de Investigação em Cirurgia Pediátrica


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