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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorMAZZETTI, Marcelo Paulo Vaccari-
dc.contributor.authorALONSO, Nivaldo-
dc.contributor.authorBROCK, Ryane Schmidt-
dc.contributor.authorAYOUB, Alexandre-
dc.contributor.authorMASSUMOTO, Sally Mizukami-
dc.contributor.authorECA, Lilian Pinero-
dc.identifier.citationJOURNAL OF CRANIOFACIAL SURGERY, v.29, n.6, p.1445-1451, 2018-
dc.description.abstractCleft lip and palate is a congenital malformation that requires a multidisciplinary treatment that evolves pediatrician, obstetrics, fetal medicine, genetics, plastic surgery, orthodontics, speech therapist, nursery, and psychology. Actually, the authors believe that it could be possible to ad protocols to use stem cells. The intrauterine diagnosis leads to preborn parental orientation and better parental collaboration to accept a precocious multidisciplinary treatment. After birth the authors' protocol is: orthodontic devices, phonoaudiology, and surgical procedures. The authors' cleft lip and palate reconstructive surgery protocol demands several steps and begins at 4 to 6-month old with rhinocheiloplasty and soft palate closure at the same moment. The treatment sequence involves the hard palate surgery (8-18 months after the first surgical step), alveoloplasty (after 10 years old), and secondary rhinoplasty (after 14 years old). New ideas to use stern cells and blood from the umbilical cord and also blood from placenta are discussed to improve final surgical results. Maternal stem cells are easy to collect, there are no damage to the patient and mother, it is autologous and it could be very useful in the authors' protocol. Nine patients with clef lip and palate were operated and had stem cells from umbilical cord blood and placenta blood injected into the bone and soft tissue during the primary procedure (rhinocheiloplasty). The stem cells activity into soft tissue and hone were evaluated. Preliminary results have shown no adverse results and improvement at the inflammatory response. A treatment protocol with stem cells was developed. It had a long time follow-up of 10 years.-
dc.relation.ispartofJournal of Craniofacial Surgery-
dc.subjectCleft lip-
dc.subjectcleft palate-
dc.subjectreconstructive surgery-
dc.subjectstem cell-
dc.subject.otherstromal cells-
dc.titleImportance of Stem Cell Transplantation in Cleft Lip and Palate Surgical Treatment Protocol-
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINS-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Marcelo Paulo Vaccari:Darcy Vargas Children Hosp, Brazilian Plast Surg Soc, Brazilian Cleft Lip & Palate Soc, Plast Surg Div, Sao Paulo, Brazil-, Ryane Schmidt:Darcy Vargas Children Hosp, Brazilian Plast Surg Soc, Plast Surg Div, Sao Paulo, Brazil-, Alexandre:Brazilian Cryogen Ctr, Sao Paulo, Brazil-, Sally Mizukami:Brazilian Cryogen Ctr, Umbil Cord Blood Lab, Sao Paulo, Brazil-, Lilian Pinero:Facial Defects Studies & Res Ctr, Sao Paulo, Brazil-
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Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCG
Departamento de Cirurgia - FM/MCG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/04
LIM/04 - Laboratório de Microcirurgia

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