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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorFERREIRA, Cristiane R.-
dc.contributor.authorZHAO, Shuchun-
dc.contributor.authorSAHOO, Malaya K.-
dc.contributor.authorPINSKY, Benjamin-
dc.contributor.authorWEBER, Jenna-
dc.contributor.authorLAGE, Luis A. P. C.-
dc.contributor.authorPEREIRA, Juliana-
dc.contributor.authorZERBINI, Maria C. N.-
dc.contributor.authorNATKUNAM, Yasodha-
dc.identifier.citationHUMAN PATHOLOGY, v.80, p.138-144, 2018-
dc.description.abstractForkhead box P3 (FOXP3) is a specific marker for regulatory T-cells (Tregs). We report 6 cases of T-cell lymphomas with Treg phenotype based on diffuse positivity for FOXP3 in tumor cells. The patients showed a median age of 56 years with a male predominance. Sites of disease included lymph nodes (4), skin (2), subcutaneous tissue (1) and bone marrow (1). All cases showed monomorphic large cells, some with Hodgkin-like or anaplastic cells. All cases expressed pan T-cell markers and lacked cytotoxic markers; one case showed diffuse PD1 staining. Only one case harbored human T-lymphotrophic virus (HTLV)-1 DNA within tumor cells and was classified as adult T-cell leukemia/lymphoma (ATLL). Among 5 HTLV1-negative cases, 3 were classified as peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) and 2 fulfilled criteria for ALK-negative anaplastic large cell lymphoma (ALCL) with diffuse and strong CD30 positivity. We concluded that Treg phenotype may be rarely seen in HTLV1-negative cases, such as PTCL, NOS and ALK-negative ALCL. Our findings expand the spectrum of T-cell lymphomas with regulatory phenotype and suggest that consideration should be given to HTLV1 DNA testing in the appropriate clinical setting to rule out ATLL.-
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP) [2016/09180-0]-
dc.relation.ispartofHuman Pathology-
dc.subjectRegulatory T-Cell-
dc.subject.otherlymphotropic virus-
dc.subject.otherpd-l1 expression-
dc.subject.otherfoxp3 expression-
dc.titleFOXP3-positive T-cell lymphomas in non-HTLV1 carriers include ALK-negative anaplastic large cell lymphoma: expanding the spectrum of T-cell lymphomas with regulatory phenotype-
dc.rights.holderCopyright W B SAUNDERS CO-ELSEVIER INC-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Shuchun:Stanford Univ, Dept Pathol, Sch Med, L235,300 Pasteur Dr, Stanford, CA 94305 USA-, Malaya K.:Stanford Univ, Dept Pathol, Sch Med, L235,300 Pasteur Dr, Stanford, CA 94305 USA-, Benjamin:Stanford Univ, Dept Pathol, Sch Med, L235,300 Pasteur Dr, Stanford, CA 94305 USA-, Jenna:Stanford Univ, Dept Pathol, Sch Med, L235,300 Pasteur Dr, Stanford, CA 94305 USA-, Yasodha:Stanford Univ, Dept Pathol, Sch Med, L235,300 Pasteur Dr, Stanford, CA 94305 USA-
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Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - HU
Hospital Universitário - HU

Artigos e Materiais de Revistas Científicas - LIM/14
LIM/14 - Laboratório de Investigação em Patologia Hepática

Artigos e Materiais de Revistas Científicas - LIM/31
LIM/31 - Laboratório de Genética e Hematologia Molecular

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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