Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/29331
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorFERREIRA, Cristiane R.-
dc.contributor.authorZHAO, Shuchun-
dc.contributor.authorSAHOO, Malaya K.-
dc.contributor.authorPINSKY, Benjamin-
dc.contributor.authorWEBER, Jenna-
dc.contributor.authorLAGE, Luis A. P. C.-
dc.contributor.authorPEREIRA, Juliana-
dc.contributor.authorZERBINI, Maria C. N.-
dc.contributor.authorNATKUNAM, Yasodha-
dc.date.accessioned2018-11-21T17:00:02Z-
dc.date.available2018-11-21T17:00:02Z-
dc.date.issued2018-
dc.identifier.citationHUMAN PATHOLOGY, v.80, p.138-144, 2018-
dc.identifier.issn0046-8177-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29331-
dc.description.abstractForkhead box P3 (FOXP3) is a specific marker for regulatory T-cells (Tregs). We report 6 cases of T-cell lymphomas with Treg phenotype based on diffuse positivity for FOXP3 in tumor cells. The patients showed a median age of 56 years with a male predominance. Sites of disease included lymph nodes (4), skin (2), subcutaneous tissue (1) and bone marrow (1). All cases showed monomorphic large cells, some with Hodgkin-like or anaplastic cells. All cases expressed pan T-cell markers and lacked cytotoxic markers; one case showed diffuse PD1 staining. Only one case harbored human T-lymphotrophic virus (HTLV)-1 DNA within tumor cells and was classified as adult T-cell leukemia/lymphoma (ATLL). Among 5 HTLV1-negative cases, 3 were classified as peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) and 2 fulfilled criteria for ALK-negative anaplastic large cell lymphoma (ALCL) with diffuse and strong CD30 positivity. We concluded that Treg phenotype may be rarely seen in HTLV1-negative cases, such as PTCL, NOS and ALK-negative ALCL. Our findings expand the spectrum of T-cell lymphomas with regulatory phenotype and suggest that consideration should be given to HTLV1 DNA testing in the appropriate clinical setting to rule out ATLL.-
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP) [2016/09180-0]-
dc.language.isoeng-
dc.publisherW B SAUNDERS CO-ELSEVIER INC-
dc.relation.ispartofHuman Pathology-
dc.rightsrestrictedAccess-
dc.subjectATLL-
dc.subjectFOXP3-
dc.subjectPTCL-NOS-
dc.subjectALK-ALCL-
dc.subjectRegulatory T-Cell-
dc.subjectLymphoma-
dc.subjectImmunohistochemistry-
dc.subject.otherleukemia-virus-
dc.subject.otherlymphotropic virus-
dc.subject.otherpd-l1 expression-
dc.subject.otherfoxp3 expression-
dc.subject.otherleukemia/lymphoma-
dc.subject.otherleukaemia/lymphoma-
dc.subject.otherinfiltration-
dc.subject.otherprognosis-
dc.subject.otherfeatures-
dc.subject.otherimmunity-
dc.titleFOXP3-positive T-cell lymphomas in non-HTLV1 carriers include ALK-negative anaplastic large cell lymphoma: expanding the spectrum of T-cell lymphomas with regulatory phenotype-
dc.typearticle-
dc.rights.holderCopyright W B SAUNDERS CO-ELSEVIER INC-
dc.identifier.doi10.1016/j.humpath.2018.06.001-
dc.identifier.pmid29898383
dc.subject.wosPathology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalZHAO, Shuchun:Stanford Univ, Dept Pathol, Sch Med, L235,300 Pasteur Dr, Stanford, CA 94305 USA-
hcfmusp.author.externalSAHOO, Malaya K.:Stanford Univ, Dept Pathol, Sch Med, L235,300 Pasteur Dr, Stanford, CA 94305 USA-
hcfmusp.author.externalPINSKY, Benjamin:Stanford Univ, Dept Pathol, Sch Med, L235,300 Pasteur Dr, Stanford, CA 94305 USA-
hcfmusp.author.externalWEBER, Jenna:Stanford Univ, Dept Pathol, Sch Med, L235,300 Pasteur Dr, Stanford, CA 94305 USA-
hcfmusp.author.externalNATKUNAM, Yasodha:Stanford Univ, Dept Pathol, Sch Med, L235,300 Pasteur Dr, Stanford, CA 94305 USA-
hcfmusp.description.beginpage138-
hcfmusp.description.endpage144-
hcfmusp.description.volume80-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000447817100017-
hcfmusp.origem.id2-s2.0-85052644104-
hcfmusp.publisher.cityPHILADELPHIA-
hcfmusp.publisher.countryUSA-
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dc.description.indexMEDLINE-
dc.identifier.eissn1532-8392-
hcfmusp.citation.scopus1-
hcfmusp.scopus.lastupdate2022-06-17-
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

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