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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorSAPINA-BELTRAN, Esther-
dc.contributor.authorTORRES, Gerard-
dc.contributor.authorMARTINEZ-ALONSO, Montserrat-
dc.contributor.authorSANCHEZ-DE-LA-TORRE, Manuel-
dc.contributor.authorFRANCH, Maria-
dc.contributor.authorBRAVO, Carmen-
dc.contributor.authorMASA, Juan F.-
dc.contributor.authorFELEZ, Miguel-
dc.contributor.authorFORTUNA-GUTIERREZ, Ana Maria-
dc.contributor.authorABAD, Jorge-
dc.contributor.authorGARCIA-RIO, Francisco-
dc.contributor.authorDRAGER, Luciano F.-
dc.contributor.authorCHI-HANG, Ronald Lee-
dc.contributor.authorMARTINEZ-GARCIA, Miguel Angel-
dc.contributor.authorBARBE, Ferran-
dc.contributor.authorDALMASES, Mireia-
dc.identifier.citationARCHIVOS DE BRONCONEUMOLOGIA, v.54, n.10, p.518-523, 2018-
dc.description.abstractIntroduction: Patients with resistant hypertension (RH) have a high risk of developing cardiovascular events; therefore, new therapeutic approaches to better control blood pressure may be useful in improving cardiovascular outcomes. The prevalence of obstructive sleep apnea (OSA) is very high among patients with RH. Continuous positive airway pressure (CPAP) has been shown to be an effective treatment for reducing blood pressure in patients with RH. Nevertheless, the long-term effect of CPAP treatment on cardiovascular outcomes has not been explored. The main objective of the SARAH study is to assess the impact of OSA and its treatment on cardiovascular outcomes (morbidity and mortality) in patients with RH. Methods: This study is a multi-center, prospective, observational cohort study. A total of 1371 patients with RH will be enrolled in the study and followed once a year for five years. At inclusion, ambulatory blood pressure monitoring (ABPM) and a sleep study will be performed in all subjects. Socio-demographic, clinical and cardiovascular variables will be collected at baseline and follow-up. Subsequently, subjects with OSA will be managed according to local standard practice. Based on the OSA diagnosis and its treatment, three cohorts of subjects with RH will be defined: non-OSA, treated OSA and non-treated OSA. Conclusions: This study will contribute to elucidating the long-term impact of OSA treatments on blood pressure control and cardiovascular outcomes in patients with RH. These results will contribute to improve the cardiovascular prognosis of patients with RH.-
dc.description.sponsorshipFondos recibidos por el ISCIII [PI16/00489, DTS15/00145]-
dc.description.sponsorshipfondos FEDER ""Una manera de hacer Europa""-
dc.description.sponsorshipSpanish Respiratory Society (SEPAR)-
dc.description.sponsorshipResMed Foundation-
dc.publisherELSEVIER DOYMA SL-
dc.relation.ispartofArchivos de Bronconeumologia-
dc.subjectAmbulatory blood pressure monitoring-
dc.subjectContinuous positive airway pressure-
dc.subjectResistant hypertension-
dc.subjectSleep apnea-
dc.subject.otherpositive airway pressure-
dc.subject.otherhigh blood-pressure-
dc.titleRationale and Methodology of the SARAH Trial: Long-Term Cardiovascular Outcomes in Patients With Resistant Hypertension and Obstructive Sleep Apnea-
dc.rights.holderCopyright ELSEVIER DOYMA SL-
dc.subject.wosRespiratory System-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Esther:Hosp Univ Arnau de Vilanova & Santa Maria, Grp Translat Res Resp Med, IRBLleida, Lleida, Cataluna, Spain-, Gerard:Hosp Univ Arnau de Vilanova & Santa Maria, Grp Translat Res Resp Med, IRBLleida, Lleida, Cataluna, Spain-, Montserrat:Univ Lleida, Biostat Unit, IRBLleida, Lleida, Cataluna, Spain-, Manuel:Hosp Univ Arnau de Vilanova & Santa Maria, Grp Translat Res Resp Med, IRBLleida, Lleida, Cataluna, Spain; Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain-, Maria:Hosp Santa Maria, Internal Med Dept, Lleida, Cataluna, Spain-, Carmen:Hosp Santa Maria, Internal Med Dept, Lleida, Cataluna, Spain-, Juan F.:Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain; Hosp San Pedro de Alcantara, Resp Dept, Caceres, Extremadura, Spain-, Miguel:Hosp del Mar, Unit Sleep Breathing Disorders, Resp Dept, Barcelona, Cataluna, Spain-, Ana Maria:Hosp Santa Creu & Sant Pau, Resp Dept, Barcelona, Cataluna, Spain-, Jorge:Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain; Hosp Badalona Germans Trias & Pujol, Resp Dept, Badalona, Cataluna, Spain-, Francisco:Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain; Hosp Univ La Paz, IdiPAZ, Resp Dept, Madrid, Spain-, Ronald Lee:Natl Univ Heart Ctr Singapore, Dept Cardiol, Singapore, Singapore-, Miguel Angel:Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain; Hosp Univ & Politecn La Fe, Resp Dept, Valencia, Spain-, Ferran:Hosp Univ Arnau de Vilanova & Santa Maria, Grp Translat Res Resp Med, IRBLleida, Lleida, Cataluna, Spain; Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain-, Mireia:Hosp Univ Arnau de Vilanova & Santa Maria, Grp Translat Res Resp Med, IRBLleida, Lleida, Cataluna, Spain; Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain-
hcfmusp.relation.referenceBazzano LA, 2007, HYPERTENSION, V50, P417, DOI 10.1161/HYPERTENSIONAHA.106.085175-
hcfmusp.relation.referenceCalhoun DA, 2008, CIRCULATION, V117, pE510, DOI 10.1161/CIRCULATIONAHA.108.189141-
hcfmusp.relation.referenceChobanian AV, 2003, JAMA-J AM MED ASSOC, V289, P2560, DOI 10.1001/jama.289.19.2560-
hcfmusp.relation.referenceDaugherty SL, 2012, CIRCULATION, V125, P1635, DOI 10.1161/CIRCULATIONAHA.111.068064-
hcfmusp.relation.referencede la Sierra A, 2011, HYPERTENSION, V57, P898, DOI 10.1161/HYPERTENSIONAHA.110.168948-
hcfmusp.relation.referencede Oliveira AC, 2014, AM J RESP CRIT CARE, V190, P345, DOI 10.1164/rccm.201403-0479LE-
hcfmusp.relation.referenceEgan BM, 2011, CIRCULATION, V124, P1046, DOI 10.1161/CIRCULATIONAHA.111.030189-
hcfmusp.relation.referenceGoncalves SC, 2007, CHEST, V132, P1858, DOI 10.1378/chest.07-1170-
hcfmusp.relation.referenceGonzaga C, 2015, J HUM HYPERTENS, V29, P705, DOI 10.1038/jhh.2015.15-
hcfmusp.relation.referenceKumbhani DJ, 2013, EUR HEART J, V34, P1204, DOI 10.1093/eurheartj/ehs368-
hcfmusp.relation.referenceLei Q, 2017, J BRAS PNEUMOL, V43, P373, DOI [10.1590/S1806-37562016000000190, 10.1590/s1806-37562016000000190]-
hcfmusp.relation.referenceLevy P, 2015, NATURE REV DIS PRIME, V25, P1-
hcfmusp.relation.referenceLitvin AY, 2013, VASC HEALTH RISK MAN, V9, P229, DOI 10.2147/VHRM.S40231-
hcfmusp.relation.referenceLogan AG, 2001, J HYPERTENS, V19, P2271, DOI 10.1097/00004872-200112000-00022-
hcfmusp.relation.referenceLozano L, 2010, J HYPERTENS, V28, P2161, DOI 10.1097/HJH.0b013e32833b9c63-
hcfmusp.relation.referenceMarin JM, 2005, LANCET, V365, P1046, DOI 10.1016/S0140-6736(05)71141-7-
hcfmusp.relation.referenceMartinez-Garcia MA, 2013, JAMA-J AM MED ASSOC, V310, P2407, DOI 10.1001/jama.2013.281250-
hcfmusp.relation.referenceMuxfeldt ES, 2015, HYPERTENSION, V65, P736, DOI 10.1161/HYPERTENSIONAHA.114.04852-
hcfmusp.relation.referencePedrosa RP, 2013, CHEST, V144, P1487, DOI 10.1378/chest.13-0085-
hcfmusp.relation.referencePedrosa RP, 2011, HYPERTENSION, V58, P811, DOI 10.1161/HYPERTENSIONAHA.111.179788-
hcfmusp.relation.referencePersell SD, 2011, HYPERTENSION, V57, P1076, DOI 10.1161/HYPERTENSIONAHA.111.170308-
hcfmusp.relation.referenceSanchez-de-la-Torre M, 2013, LANCET, V1, P1-
hcfmusp.relation.referenceSanchez-de-la-Torre M, 2015, J AM COLL CARDIOL, V66, P1023, DOI 10.1016/j.jacc.2015.06.1315-
hcfmusp.relation.referenceSchlaich MP, 2013, J AM COLL CARDIOL, V62, P2031, DOI 10.1016/j.jacc.2013.08.1616-
hcfmusp.relation.referenceSilverberg D S, 2001, Curr Hypertens Rep, V3, P209, DOI 10.1007/s11906-001-0040-8-
hcfmusp.relation.referenceTorres G, 2015, CHEST, V148, P824, DOI 10.1378/chest.15-0136-
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/09
LIM/09 - Laboratório de Pneumologia

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