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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorOLIVEIRA, Luciano Fonseca Lemos de-
dc.contributor.authorTHACKERAY, James T.-
dc.contributor.authorMARIN NETO, Jose Antonio-
dc.contributor.authorROMANO, Minna Moreira Dias-
dc.contributor.authorCARVALHO, Eduardo Elias Vieira de-
dc.contributor.authorMEJIA, Jorge-
dc.contributor.authorTANAKA, Denise Mayumi-
dc.contributor.authorSILVA, Grace Kelly da-
dc.contributor.authorABDALLA, Douglas Reis-
dc.contributor.authorMALAMUT, Carlos-
dc.contributor.authorBENGEL, Frank M.-
dc.contributor.authorHIGUCHI, Maria de Lourdes-
dc.contributor.authorSCHMIDT, Andre-
dc.contributor.authorCUNHA-NETO, Edecio-
dc.contributor.authorSIMOES, Marcus Vinicius-
dc.identifier.citationJOURNAL OF NUCLEAR MEDICINE, v.59, n.9, p.1430-1436, 2018-
dc.description.abstractAltered myocardial perfusion is a common finding in chronic Chagas cardiomyopathy (CCC), but its underlying histologic changes have not been elucidated. We investigated the occurrence of myocardial perfusion defects (MPDs) and the correlated regional changes to histology in an experimental model of CCC in hamsters. Methods: Female Syrian hamsters (n = 34) were infected with 3.5 x 10(4) to 10(5) trypomastigote forms of Trypanosoma cruzi, Y strain, and 6-10 mo afterward underwent in vivo imaging including resting Tc-99m-sestamibi SPECT, segmental and global left ventricular function assessment using 2-dimensional echocardiography, and F-18-FDG PET for evaluation of myocardial viability. Histologic analysis included quantification of fibrosis, inflammatory infiltration, and the diameter and density of myocardial microcirculation. Results: MPDs were present in 17 (50%) of the infected animals. Histologic analysis revealed no transmural scar in segments with an MPD, and normal or mildly reduced F-18-FDG uptake, indicating viable myocardium. Infected animals with an MPD, in comparison to infected animals without an MPD and control animals, showed a lower left ventricular ejection fraction (P = 0.012), a higher wall motion score index (P = 0.004), and a higher extent of inflammatory infiltration (P = 0.018) but a similar extent of fibrosis (P = 0.15) and similar microvascular diameter and density (P > 0.05). Segments with an MPD (n = 65), as compared with normally perfused regions in the same animal (n = 156), showed a higher wall motion score index (P = 0.005) but a similar extent of inflammatory infiltration, a similar extent of fibrosis, and a similar microvascular diameter and density. Conclusion: Resting MPDs are frequent in experimental CCC and are associated with myocardial inflammation but do not designate scar tissue, corresponding to regions with metabolically viable myocardium.-
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP) [2015/25209-5, 2011/03261-4]-
dc.relation.ispartofJournal of Nuclear Medicine-
dc.subjectchronic Chagas cardiomyopathy-
dc.subjectmyocardial perfusion-
dc.subjectmyocardial inflammation-
dc.subject.othertrypanosoma-cruzi infection-
dc.subject.othermitochondrial dysfunction-
dc.subject.otherdilated cardiomyopathy-
dc.titleRegional Myocardial Perfusion Disturbance in Experimental Chronic Chagas Cardiomyopathy-
dc.rights.holderCopyright SOC NUCLEAR MEDICINE INC-
dc.subject.wosRadiology, Nuclear Medicine & Medical Imaging-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Luciano Fonseca Lemos de:Univ Sao Paulo, Med Sch Ribeirao Preto, 3900 Bandeirantes Ave, BR-14048900 Ribeirao Preto, SP, Brazil-, James T.:Hannover Med Sch, Dept Nucl Med, Hannover, Germany- NETO, Jose Antonio:Univ Sao Paulo, Med Sch Ribeirao Preto, 3900 Bandeirantes Ave, BR-14048900 Ribeirao Preto, SP, Brazil-, Minna Moreira Dias:Univ Sao Paulo, Med Sch Ribeirao Preto, 3900 Bandeirantes Ave, BR-14048900 Ribeirao Preto, SP, Brazil-, Eduardo Elias Vieira de:Univ Sao Paulo, Med Sch Ribeirao Preto, 3900 Bandeirantes Ave, BR-14048900 Ribeirao Preto, SP, Brazil-, Jorge:Hosp Israelita Albert Einstein, Sao Paulo, Brazil-, Denise Mayumi:Univ Sao Paulo, Med Sch Ribeirao Preto, 3900 Bandeirantes Ave, BR-14048900 Ribeirao Preto, SP, Brazil-, Grace Kelly da:Univ Sao Paulo, Med Sch Ribeirao Preto, 3900 Bandeirantes Ave, BR-14048900 Ribeirao Preto, SP, Brazil-, Douglas Reis:Fac Human Talent, Hlth Dept, Uberaba, Brazil-, Carlos:Natl Commiss Nucl Energy CNEN, Nucl Technol Dev Ctr CDTN, Belo Horizonte, MG, Brazil-, Frank M.:Hannover Med Sch, Dept Nucl Med, Hannover, Germany-, Andre:Univ Sao Paulo, Med Sch Ribeirao Preto, 3900 Bandeirantes Ave, BR-14048900 Ribeirao Preto, SP, Brazil-, Marcus Vinicius:Univ Sao Paulo, Med Sch Ribeirao Preto, 3900 Bandeirantes Ave, BR-14048900 Ribeirao Preto, SP, Brazil-
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/19
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular

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