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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorGENARO, Isabella Santos de-
dc.contributor.authorALMEIDA, Francine Maria de-
dc.contributor.authorHIZUME-KUNZLER, Deborah Camargo-
dc.contributor.authorMORIYA, Henrique Takachi-
dc.contributor.authorSILVA, Ronaldo Aparecido-
dc.contributor.authorCRUZ, Joao Carlos Goncalves-
dc.contributor.authorLOPES, Renan Boeira-
dc.contributor.authorRIGHETTI, Renato Fraga-
dc.contributor.authorVIEIRA, Rodolfo de Paula-
dc.contributor.authorSAIKI, Mitiko-
dc.contributor.authorMARTINS, Milton Arruda-
dc.contributor.authorTIBERIO, Iolanda de Fatima Lopes Calvo-
dc.contributor.authorARANTES-COSTA, Fernanda Magalhaes-
dc.contributor.authorSARAIVA-ROMANHOLO, Beatriz Mangueira-
dc.date.accessioned2018-11-21T17:00:04Z-
dc.date.available2018-11-21T17:00:04Z-
dc.date.issued2018-
dc.identifier.citationSCIENTIFIC REPORTS, v.8, article ID 12636, 13p, 2018-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29347-
dc.description.abstractWork-exacerbated asthma (WEA) is defined as preexisting asthma that worsens with exposure to irritants [e.g., chlorine (Cl-2) derivatives] in the workplace. The maximum allowable concentration in the workplace of Cl-2 exposure is 3 mg/m(3) (described in OSHA). We investigated in an experimental asthma model in mice the effects of a single exposure to a sodium hypochlorite dose with this allowed chlorine concentration and a tenfold higher dose. Acute chlorine exposure at 3.3 mg/m(3) in the OVA-sensitized group increased eosinophils in the peribronquial infiltrate, cytokine production, nasal mucus production and the number of iNOS positive cells in the distal lung compared to only sensitized mice. The exposure to a higher dose of 33.3 mg/m(3) in the OVA-sensitized group resulted in an increase in respiratory system elastance, in the total and differential numbers of inflammatory cells in bronchoalveolar lavage fluid, IL-4, IL-5, and IL-17 in the lungs, eosinophils in peribronquial infiltrate and mucus content in nasal compared to non-exposed and sensitized animals. In this asthma model, chorine exposures at an allowable dose, contributed to the potentiation of Th2 responses. The functional alterations were associated with increased iNOS and ROCK-2 activation in the distal lung.-
dc.description.sponsorshipSao Paulo Research Foundation, (FAPESP) [2009/53904-9, 2012/15165-2]-
dc.description.sponsorshipExperimental Therapeutic Laboratory I, School of Medicine, University of Sao Paulo, School of Medicine Foundation (FFM/USP) [LIM 20]-
dc.description.sponsorshipAUXPE/PROAP [2696/2013]-
dc.language.isoeng-
dc.publisherNATURE PUBLISHING GROUP-
dc.relation.ispartofScientific Reports-
dc.rightsopenAccess-
dc.subject.otherdiesel exhaust particles-
dc.subject.otherairway epithelial-cells-
dc.subject.otherrho-kinase inhibition-
dc.subject.othernitric-oxide synthase-
dc.subject.otheroccupational asthma-
dc.subject.otherlung inflammation-
dc.subject.otherstereological methods-
dc.subject.othersodium-hypochlorite-
dc.subject.otherconsensus statement-
dc.subject.otherhydrochloric-acid-
dc.titleLow dose of chlorine exposure exacerbates nasal and pulmonary allergic inflammation in mice-
dc.typearticle-
dc.rights.holderCopyright NATURE PUBLISHING GROUP-
dc.identifier.doi10.1038/s41598-018-30851-6-
dc.identifier.pmid30135462
dc.subject.wosMultidisciplinary Sciences-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalGENARO, Isabella Santos de:Publ Employee Sao Paulo Hosp IAMSPE, Sao Paulo, Brazil; Univ Sao Paulo, Sch Med, Dept Med LIM 20, Sao Paulo, Brazil-
hcfmusp.author.externalMORIYA, Henrique Takachi:Univ Sao Paulo, Escola Politecn, Biomed Engn Lab, Sao Paulo, Brazil-
hcfmusp.author.externalCRUZ, Joao Carlos Goncalves:Univ City Sao Paulo UNICID, Sao Paulo, Brazil-
hcfmusp.author.externalLOPES, Renan Boeira:Univ City Sao Paulo UNICID, Sao Paulo, Brazil-
hcfmusp.author.externalVIEIRA, Rodolfo de Paula:Univ Brasil, Postgrad Program Bioengn, Sao Paulo, Brazil; Brazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Jose Dos Campos, Brazil-
hcfmusp.author.externalSAIKI, Mitiko:IPEN CNEN SP, Nucl & Energy Res Inst, Sao Paulo, Brazil-
hcfmusp.description.articlenumber12636-
hcfmusp.description.volume8-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000442388700003-
hcfmusp.origem.id2-s2.0-85052084767-
hcfmusp.publisher.cityLONDON-
hcfmusp.publisher.countryENGLAND-
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