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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorMOREIRA, Rodrigo C.-
dc.contributor.authorMILL, Jose G.-
dc.contributor.authorGRINSZTEJN, Beatriz-
dc.contributor.authorVELOSO, Valdilea-
dc.contributor.authorFONSECA, Maria de Jesus-
dc.contributor.authorGRIEP, Rosane H.-
dc.contributor.authorBENSENOR, Isabela-
dc.contributor.authorCARDOSO, Sandra W.-
dc.contributor.authorLOTUFO, Paulo-
dc.contributor.authorCHOR, Dora-
dc.contributor.authorPACHECO, Antonio G.-
dc.identifier.citationJAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, v.78, n.1, p.73-81, 2018-
dc.description.abstractIntroduction: Aortic stiffness measured by carotid-femoral pulse wave velocity (cf-PWV) is a marker of subclinical atherosclerosis. We propose to assess whether HIV infection is associated with arterial stiffness and their determinants in HIV-infected subjects. Methods: We compared data from an HIV cohort (644 patients, HIV+) in Rio de Janeiro with 2 groups: 105 HIV-negative (HIV-) individuals and 14,873 participants of the ELSA-Brasil study. We used multivariable linear regression to investigate factors associated with cf-PWV and whether HIV was independently associated with aortic stiffness and propensity score weighting to control for imbalances between groups. Results: From 15,860 participants, cf-PWV was obtained in 15,622 (98.5%). Median age was 51 (interquartile range 45-58), 44.41 (35.73, 54.72), and 43.60 (36.01, 50.79) years (P < 0.001), and median cf-PWV (m/s; interquartile range) was 9.0 (8.10, 10.20), 8.70 (7.90, 10.20), and 8.48 (7.66, 9.40) for ELSA-Brasil, HIV- and HIV+, respectively (P < 0.001). In the final weighted multivariable models, HIV group was not associated with cf-PWV when compared either with ELSA-Brasil [beta = -0.05; 95% confidence interval (CI) = -0.23; P = 0.12; P = 0.52] or with the HIV- groups (beta = 0.10; 95% CI = -0.10; 0, 31; P = 0.32). Traditional risk factors were associated with higher cf-PWV levels in the HIV+ group, particularly waist-tohip ratio (beta = 0.20; 95% CI = 0.10; 0.30; P < 0.001, result per one SD change). Conclusions: HIV infection was not associated with higher aortic stiffness according to our study. In HIV-infected subjects, the stiffness of large arteries is mainly associated with traditional risk factors and not to the HIV infection per se.-
dc.description.sponsorshipFundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro [E-26/102398/2009, E-26/201.471/2014]-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico [01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ, 407446/2012-5, 304614/2012-2]-
dc.description.sponsorshipPrograma Estrategico de Apoio a Pesquisa em Saude [407446/2012-5]-
dc.relation.ispartofJAIDS-Journal of Acquired Immune Deficiency Syndromes-
dc.subjectpeople living with HIV-
dc.subjectcardiovascular risk factors-
dc.subjectarterial stiffness-
dc.subject.otheractive antiretroviral therapy-
dc.subject.otherincreased arterial stiffness-
dc.subject.otheracute myocardial-infarction-
dc.subject.otherpulse-wave velocity-
dc.titleHIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants-Cross-sectional Results of INI-ELSA-BRASIL-
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINS-
dc.contributor.groupauthorINI ELSA BRASIL-
dc.subject.wosInfectious Diseases-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Rodrigo C.:Inst Nacl Infectol Evandro Chagas, Fundacao Oswaldo Cruz, Rio De Janeiro, Brazil; Fundacao Oswaldo Cruz, Programa Computacao Cient, Rio De Janeiro, Brazil-, Jose G.:Univ Fed Espirito Santo, Dept Ciencias Fisiol, Vitoria, Brazil-, Beatriz:Inst Nacl Infectol Evandro Chagas, Fundacao Oswaldo Cruz, Rio De Janeiro, Brazil-, Valdilea:Inst Nacl Infectol Evandro Chagas, Fundacao Oswaldo Cruz, Rio De Janeiro, Brazil-, Maria de Jesus:Fundacao Oswaldo Cruz, Dept Epidemiol & Metodos Quantitat Saude, Rio De Janeiro, Brazil-, Rosane H.:Fundacao Oswaldo Cruz, Lab Hlth & Environm Educ, Rio De Janeiro, Brazil-, Sandra W.:Inst Nacl Infectol Evandro Chagas, Fundacao Oswaldo Cruz, Rio De Janeiro, Brazil-, Dora:Fundacao Oswaldo Cruz, Dept Epidemiol & Metodos Quantitat Saude, Rio De Janeiro, Brazil-, Antonio G.:Fundacao Oswaldo Cruz, Programa Computacao Cient, Rio De Janeiro, Brazil-
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - LIM/20
LIM/20 - Laboratório de Terapêutica Experimental

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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