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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorSILVA, Veronica Torres Costa e-
dc.contributor.authorCAIRES, Renato Antunes-
dc.contributor.authorBEZERRA, Juliana Silva-
dc.contributor.authorCOSTALONGA, Elerson C.-
dc.contributor.authorOLIVEIRA, Ana Paula Leandro-
dc.contributor.authorCOELHO, Fernanda Oliveira-
dc.contributor.authorFUKUSHIMA, Julia T.-
dc.contributor.authorSOARES, Cilene Muniz-
dc.contributor.authorOIKAWA, Luciane-
dc.contributor.authorHAJJAR, Ludhmila Abrahao-
dc.contributor.authorBURDMANN, Emmanuel A.-
dc.identifier.citationJOURNAL OF CRITICAL CARE, v.47, p.302-309, 2018-
dc.description.abstractPurpose: This study aimed to evaluate the safety and efficacy of a regional citrate anticoagulation (RCA) protocol for continuous venovenous hemodialysis (CVVHD) in cancer patients with acute kidney injury (AKI) in the intensive care unit (ICU) setting. Material and methods: One hundred twenty two consecutive ICU cancer patients with AKI treated with citrate-based CVVHD were prospectively evaluated in this prospective observational study. Results: A total of 7198 h of CVVHD therapy (250 filters) were performed. Patients were 613 +/- 15.7 years old, 78% had solid cancer and the main AKI cause was sepsis (50%). The in-hospital mortality was 78.7%. Systemic ionized calcium (SCai) was 435 (4.10-4.60) mg/dL, severe hypocalcemia (SCai <3.6 mg/dL) was observed in 4.3% of procedures and post-filter ionized calcium was 1.60 (1.40-1.80) mg/dL. Median filter pa tency was 24.8 (11-43) hours. Factors related to filter clotting were: no tumor evidence (OR 0.44, C10.18-0.99); genitourinary tumor (OR 1.83, CI 1.18-2.81); platelets number (each 10,000/mm(3)) (OR 1.02, CI 1.00-1.04); International Normatized Ratio (INR) (OR 059, CI 0.41-0.85) and citrate dose (each 10 mL/h) (OR 0.88, CI 0.82-0.95). Conclusion: Filler plenty was relatively short and dotting was associated with active cancer disease, genitourinary tumor, lower citrate dose and lower INR. (C) 2018 Published by Elsevier Inc.-
dc.relation.ispartofJournal of Critical Care-
dc.subjectAcute kidney injury-
dc.subjectContinuous renal replacement therapy-
dc.subjectRegional citrate anticoagulation-
dc.subjectCancer patients-
dc.subjectIntensive care unit-
dc.subject.otherrenal replacement therapy-
dc.subject.otherrandomized controlled-trial-
dc.subject.otherlow-efficiency dialysis-
dc.subject.otherintensive-care units-
dc.subject.otherheparin anticoagulation-
dc.subject.othervenous thromboembolism-
dc.subject.othersystemic heparin-
dc.titleUse of regional citrate anticoagulation for continuous venovenous hemodialysis in critically ill cancer patients with acute kidney injury-
dc.rights.holderCopyright W B SAUNDERS CO-ELSEVIER INC-
dc.subject.wosCritical Care Medicine-
dc.type.categoryoriginal article-
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MCP
Departamento de Cardio-Pneumologia - FM/MCP

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/08
LIM/08 - Laboratório de Anestesiologia

Artigos e Materiais de Revistas Científicas - LIM/12
LIM/12 - Laboratório de Pesquisa Básica em Doenças Renais

Artigos e Materiais de Revistas Científicas - LIM/29
LIM/29 - Laboratório de Nefrologia Celular, Genética e Molecular

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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