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Title: Genomic ancestry as a predictor of haemodynamic profile in heart failure
Authors: BERNARDEZ-PEREIRA, SabrinaGIOLI-PEREIRA, LucianaMARCONDES-BRAGA, Fabiana G.SANTOS, Paulo Caleb Junior LimaSPINA, Joceli Mabel RochaHORIMOTO, Andrea Roseli Vancan RussoSANTOS, Hadassa CamposBACAL, FernandoFERNANDES, FabioMANSUR, Alfredo JosePIETROBON, RicardoKRIEGER, Jose EduardoMESQUITA, Evandro TinocoPEREIRA, Alexandre Costa
Citation: OPEN HEART, v.3, n.2, article ID UNSP e000434, 9p, 2016
Abstract: Objective: The aim of this study is to assess the association between genetic ancestry, self-declared race and haemodynamic parameters in patients with chronic heart failure (HF). Methods: Observational, cross-sectional study. Eligible participants were aged between 18 and 80 years; ejection fraction was <= 50%. Patients underwent genetic analysis of ancestry informative markers, echocardiography and impedance cardiography (ICG). Race was determined by self-classification into two groups: white and non-white. Genomic ancestry was estimated using a panel of 101 348 polymorphic markers and three continental reference populations (European, African and Native American). Results: Our study included 362 patients with HF between August 2012 and August 2014. 123 patients with HF declared themselves as white and 234 patients declared themselves as non-white. No statistically significant differences were found regarding the ICG parameters according to self-declared race. The Amerindian ancestry was positively correlated with systolic time ratio (r=0.109, p<0.05). The thoracic fluid content index (r=0.124. p<0.05), E wave peak (r=0.127. p<0.05) and E/e' ratio (r=0.197. p<0.01) were correlated positively with African ancestry. In multiple linear regression, African ancestry remained associated with the E/e0 ratio, even after adjustment to risk factors. Conclusions: The African genetic ancestry was associated with worse parameters of diastolic function; the Amerindian ancestry correlated with a worse pattern of ventricular contractility, while self-declared colour was not helpful to infer haemodynamic profiles in HF.
Appears in Collections:Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/11
Artigos e Materiais de Revistas Científicas - LIM/13

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