Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/29436
Title: | Role of Histamine in Modulating the Immune Response and Inflammation |
Authors: | BRANCO, Anna Claudia Calvielli Castelo; YOSHIKAWA, Fabio Seiti Yamada; PIETROBON, Anna Julia; SATO, Maria Notomi |
Citation: | MEDIATORS OF INFLAMMATION, article ID 9524075, 10p, 2018 |
Abstract: | Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive amine, causes symptoms such as allergies and has a pleiotropic effect that is dependent on its interaction with its four histamine receptors. In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. We also evaluate the interactions between these effects. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MDT Artigos e Materiais de Revistas Científicas - IMT Artigos e Materiais de Revistas Científicas - LIM/56 |
Files in This Item:
File | Description | Size | Format | |
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art_BRANCO_Role_of_Histamine_in_Modulating_the_Immune_Response_2018.PDF | publishedVersion (English) | 2.47 MB | Adobe PDF | View/Open |
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