Please use this identifier to cite or link to this item:
Title: Pulmonary Morphologic and Functional Abnormalities in Patients with Primary Hypogammaglobulinemia
Authors: DORNA, Mayra de BarrosCASTRO, Ana Paula B. MoschionePASTORINO, Antonio CarlosCARNEIRO-SAMPAIO, Magda M. SalesJACOB, Cristina Miuki Abe
Citation: JOURNAL OF CLINICAL IMMUNOLOGY, v.32, n.2, p.378-378, 2012
Abstract: Retrospective evaluation of 30 patients (21 M) aged 4.6–23.4 y (median 16.7 y) with predominantly humoral PID(9IDCV;14XLA;7HIGM).Mediantimeof follow-up9.2y(1.8–17.5). Median age of symptoms’ onset8mo(1–96 mo), age at diagnosis 5.8 y (7–175 mo) and diagnostic delay 4.7 y (0.2–13 y). Pneumonia was the main manifestation before diagnosis (24/30 patients) with frequency of 0.6/patient/year. After beginning IVIG, frequency of pneumonias decreased to 0.1 (p<0.001) and the frequency of sinusitis increased from0to0.55(p<0.001). Higher age at diagnosis and longer diagnostic delay were associated to bronchiectasis at diagnosis (p=0.016 and p<0.001). Seven patients developed bronchiectasis during follow-up. Spirometry (23/30 patients), 1–15 y after IVIG was abnormal in 13 (9 obstructive; 4 restrictive). Humoral PID often affects respiratory tract and IVIG reduces complications but pulmonary monitoring is essential to guarantee adequate therapeutic interventions.
Appears in Collections:

Comunicações em Eventos - FM/MPE
Departamento de Pediatria - FM/MPE

Comunicações em Eventos - HC/ICr
Instituto da Criança - HC/ICr

Comunicações em Eventos - LIM/36
LIM/36 - Laboratório de Pediatria Clínica

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.