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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMATAS, Carla Gentile
dc.contributor.authorSAMELLI, Alessandra Giannella
dc.contributor.authorMAGLIARO, Fernanda Cristina Leite
dc.contributor.authorSEGURADO, Aluisio
dc.date.accessioned2018-11-21T17:01:16Z
dc.date.available2018-11-21T17:01:16Z
dc.date.issued2018
dc.identifier.citationBRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY, v.84, n.5, p.574-582, 2018
dc.identifier.issn1808-8694
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29443
dc.description.abstractIntroduction: The Human Immunodeficiency Virus (HIV) and infections related to it can affect multiple sites in the hearing system. The use of High Activity Anti-Retroviral Therapy (HAART) can cause side effects such as ototoxicity. Thus, no consistent patterns of hearing impairment in adults with Human Immunodeficiency Virus / Acquired Immune Deficiency Syndrome have been established, and the problems that affect the hearing system of this population warrant further research. Objectives: This study aimed to compare the audiological and electrophysiological data of Human Immunodeficiency Virus-positive patients with and without Acquired Immune Deficiency Syndrome, who were receiving High Activity Anti-Retroviral Therapy, to healthy individuals. Methods: It was a cross-sectional study conducted with 71 subjects (30-48 years old), divided into groups: Research Group I: 16 Human Immunodeficiency Virus-positive individuals without Acquired Immunodeficiency Syndrome (not receiving antiretroviral treatment); Research Group II: 25 Human Immunodeficiency Virus-positive individuals with Acquired Immunodeficiency Syndrome (receiving antiretroviral treatment); Control Group: 30 healthy subjects. All individuals were tested by pure-tone air conduction thresholds at 0.25-8 kHz, extended high frequencies at 9-20 kHz, electrophysiological tests (Auditory Brainstem Response, Middle Latency Responses, Cognitive Potential). Results: Research Group I and Research Group II had higher hearing thresholds in both conventional and high frequency audiometry when compared to the control group, prolonged latency of waves I, III, V and interpeak I-V in Auditory Brainstem Response and prolonged latency of P300 Cognitive Potential. Regarding Middle Latency Responses, there was a decrease in the amplitude of the Pa wave of Research Group II compared to the Research Group I. Conclusions: Both groups with Human Immunodeficiency Virus had higher hearing thresholds when compared to healthy individuals (group exposed to antiretroviral treatment showed the worst hearing threshold) and seemed to have lower neuroelectric transmission speed along the auditory pathway in the brainstem, subcortical and cortical regions. (C) 2018 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial.
dc.description.sponsorshipFAPESP (Foundation for Research Support of the State of Sao Paulo) [55156-9]
dc.language.isoeng
dc.publisherASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIAL
dc.relation.ispartofBrazilian Journal of Otorhinolaryngology
dc.rightsopenAccess
dc.subjectAcquired immunodeficiency syndrome
dc.subjectAdults
dc.subjectAuditory evoked potentials
dc.subjectHearing loss
dc.subjectHIV
dc.subject.otherhuman-immunodeficiency-virus
dc.subject.otherhearing-loss
dc.subject.otheraids
dc.subject.othermanifestations
dc.subject.otherototoxicity
dc.subject.otherimpairment
dc.subject.otherpotentials
dc.subject.otherdisease
dc.titleAudiological and electrophysiological alterations in HIV-infected individuals subjected or not to antiretroviral therapy
dc.typearticle
dc.rights.holderCopyright ASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIAL
dc.identifier.doi10.1016/j.bjorl.2017.07.003
dc.identifier.pmid28823692
dc.subject.wosOtorhinolaryngology
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
hcfmusp.description.beginpage574
hcfmusp.description.endpage582
hcfmusp.description.issue5
hcfmusp.description.volume84
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000446305300008
hcfmusp.origem.id2-s2.0-85027464153
hcfmusp.origem.idSCIELO:S1808-86942018000500574
hcfmusp.publisher.citySAO PAULO
hcfmusp.publisher.countryBRAZIL
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dc.description.indexMEDLINE
dc.identifier.eissn1808-8686
hcfmusp.citation.scopus5
hcfmusp.scopus.lastupdate2022-07-22-
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Artigos e Materiais de Revistas Científicas - FM/MFT
Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional - FM/MFT

Artigos e Materiais de Revistas Científicas - FM/MIP
Departamento de Moléstias Infecciosas e Parasitárias - FM/MIP

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/34
LIM/34 - Laboratório de Ciências da Reabilitação

Artigos e Materiais de Revistas Científicas - LIM/49
LIM/49 - Laboratório de Protozoologia

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

Artigos e Materiais de Revistas Científicas - ODS/05
ODS/05 - Igualdade de gênero


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