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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | MAZO, Daniel Ferraz de Campos | - |
dc.contributor.author | MATTAR, Rejane | - |
dc.contributor.author | STEFANO, Jose Tadeu | - |
dc.contributor.author | SILVA-ETTO, Joyce Matie Kinoshita da | - |
dc.contributor.author | DINIZ, Marcio Augusto | - |
dc.contributor.author | DUARTE, Sebastiao Mauro Bezerra | - |
dc.contributor.author | RABELO, Fabiola | - |
dc.contributor.author | LIMA, Rodrigo Vieira Costa | - |
dc.contributor.author | CAMPOS, Priscila Brizolla de | - |
dc.contributor.author | CARRILHO, Flair Jose | - |
dc.contributor.author | OLIVEIRA, Claudia P. | - |
dc.date.accessioned | 2018-11-21T17:01:29Z | - |
dc.date.available | 2018-11-21T17:01:29Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | WORLD JOURNAL OF HEPATOLOGY, v.8, n.24, p.1019-1027, 2016 | - |
dc.identifier.issn | 1948-5182 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/29459 | - |
dc.description.abstract | AIM To assess lactase gene (LCT)-13910C>T polymorphisms in Brazilian non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) patients in comparison with healthy controls. METHODS This was a transverse observational clinical study with NAFLD patients who were followed at the Hepatology Outpatient Unit of the Hospital das Clinicas, Sao Paulo, Brazil. The polymorphism of lactase non-persistence/ lactase persistence (LCT-13910C>T) was examined by PCR-restriction fragment length polymorphism technique in 102 liver biopsy-proven NAFLD patients (steatosis in 9 and NASH in 93) and compared to those of 501 unrelated healthy volunteers. Anthropometric, clinical, biochemical and liver histology data were analyzed. Continuous variables were compared using the t or Mann-Whitney tests, and categorical data were compared with the Fisher's exact test. Univariate logistic regression and multivariate logistic regression adjusted for gender and age were performed. RESULTS No differences in the LCT-13910 genotype frequencies were noted between the NAFLD patients (66.67% of the patients with steatosis were CC, 33.33% were CT, and none were TT; 55.91% of the patients with NASH were CC, 39.78% were CT, and 4.3% were TT; P = 0.941) and the healthy controls (59.12% were CC, 35.67% were CT, and 5.21% were TT) or between the steatosis and NASH patients. That is, the distribution of the lactase non-persistence/lactase persistence polymorphism (LCT-13910C>T) in the patients with NAFLD was equal to that in the general population. In the NASH patients, the univariate analysis revealed that the lactase nonpersistence (low lactase activity or hypolactasia) phenotype was associated with higher insulin levels (23.47 +/- 15.94 mu U/mL vs 15.8 +/- 8.33 mu U/mL, P = 0.027) and a higher frequency of insulin resistance (91.84% vs 72.22%, P = 0.02) compared with the lactase persistence phenotype. There were no associations between the LCT genotypes and diabetes (P = 0.651), dyslipidaemia (P = 0.328), hypertension (P = 0.507) or liver histology in these patients. Moreover, in the NASH patients, hypolactasia was an independent risk factor for insulin resistance even after adjusting for gender and age [OR = 5.0 (95%CI: 1.35-20; P = 0.017)]. CONCLUSION The LCT-13910 genotype distribution in Brazilian NAFLD patients was the same as that of the general population, but hypolactasia increased the risk of insulin resistance in the NASH patients. | - |
dc.language.iso | eng | - |
dc.publisher | BAISHIDENG PUBLISHING GROUP INC | - |
dc.relation.ispartof | World Journal of Hepatology | - |
dc.rights | openAccess | - |
dc.subject | Lactose intolerance | - |
dc.subject | Genetic polymorphism | - |
dc.subject | Insulin resistance | - |
dc.subject | Non-alcoholic fatty liver disease | - |
dc.subject | Nonalcoholic steatohepatitis | - |
dc.title | Hypolactasia is associated with insulin resistance in nonalcoholic steatohepatitis | - |
dc.type | article | - |
dc.rights.holder | Copyright BAISHIDENG PUBLISHING GROUP INC | - |
dc.identifier.doi | 10.4254/wjh.v8.i24.1019 | - |
dc.identifier.pmid | 27648154 | |
dc.subject.wos | Gastroenterology & Hepatology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | DINIZ, Marcio Augusto:Univ Sao Paulo, Div Gastroenterol & Hepatol, Dept Gastroenterol, Sch Med, LIM 07,Av Dr Eneas de Carvalho Aguiar 255,9 Andar, BR-05403000 Sao Paulo, Brazil | - |
hcfmusp.description.beginpage | 1019 | - |
hcfmusp.description.endpage | 1027 | - |
hcfmusp.description.issue | 24 | - |
hcfmusp.description.volume | 8 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000439246300003 | - |
hcfmusp.origem.id | 2-s2.0-84988429310 | - |
hcfmusp.publisher.city | PLEASANTON | - |
hcfmusp.publisher.country | USA | - |
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dc.description.index | PubMed | - |
hcfmusp.citation.scopus | 1 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MGT Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/07 Artigos e Materiais de Revistas Científicas - ODS/03 |
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