Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/29512
Title: Efficacy and effects of transdermal hormone therapy in postmenopausal women
Authors: CORREIA, L. E. PradoALMEIDA, B. C. deBARACAT, E. ChadaSILVA, ISOARES JUNIOR, J. M.BONDUKI, C. E.HAIDAR, M. Abi
Citation: CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, v.45, n.5, p.735-740, 2018
Abstract: The authors aimed to evaluate the influence of transdermal hormone therapy (I IT) in the blood coagulation parameters. Fifty-eight postmenopausal women received: G1-transdermal estradiol (E2) (50 mg), G2-E2+oral micronized progesterone (100 mg/day), and G3-F2+ +oral medroxyprogesterone acetate (2.5 mg/day) for six months. Statistical relevance was seen mainly in G1 and G2. G1 showed a decrease in prothrombin time (PT), fibrinogen (FG), and thrombin time (TT) at six months (p < 0.05) compared to baseline values. G2 showed an increase of PT (p < 0.05) and a reduction of activated partial thromboplastin time (aPTT). AT III at three months (p < 0.01). AT RI showed an increase after six months (p < 0.05), as well as F1 + 2 (p < 0.05). G3 exhibited a decrease of PT after three and six months of transdermal LIT. Data suggests that E2 alone or E2 + OMP are correlated with some variations of anticoagulant and procoagulant factors. E2 I MPA avoids any major activation of blood coagulation in patients who receive transdermal FIT.
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Artigos e Materiais de Revistas Científicas - FM/MOG
Departamento de Obstetrícia e Ginecologia - FM/MOG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/58
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular


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