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Title: Minipuberty and Sexual Dimorphism in the Infant Human Thymus
Authors: MOREIRA-FILHO, Carlos AlbertoBANDO, Silvia YumiBERTONHA, Fernanda BernardiFERREIRA, Leandro RodriguesVINHAS, Christiana de FreitasOLIVEIRA, Lucila Habib BourguignonZERBINI, Maria Claudia NogueiraFURLANETTO, GlaucioCHACCUR, PauloCARNEIRO-SAMPAIO, Magda
Citation: SCIENTIFIC REPORTS, v.8, article ID 13169, 13p, 2018
Abstract: AIRE expression in thymus is downregulated by estrogen after puberty, what probably renders women more susceptible to autoimmune disorders. Here we investigated the effects of minipuberty on male and female infant human thymic tissue in order to verify if this initial transient increase in sex hormones - along the first six months of life - could affect thymic transcriptional network regulation and AIRE expression. Gene co-expression network analysis for differentially expressed genes and miRNA-target analysis revealed sex differences in thymic tissue during minipuberty, but such differences were not detected in the thymic tissue of infants aged 7-18 months, i.e. the non-puberty group. AIRE expression was essentially the same in both sexes in minipuberty and in non-puberty groups, as assessed by genomic and immunohistochemical assays. However, A/RE-interactors networks showed several differences in all groups regarding gene-gene expression correlation. Therefore, minipuberty and genomic mechanisms interact in shaping thymic sexual dimorphism along the first six months of life.
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Artigos e Materiais de Revistas Científicas - FM/MPE
Departamento de Pediatria - FM/MPE

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - LIM/14
LIM/14 - Laboratório de Investigação em Patologia Hepática

Artigos e Materiais de Revistas Científicas - LIM/36
LIM/36 - Laboratório de Pediatria Clínica

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