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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorIBANEZ, Humberto C.-
dc.contributor.authorMELANDA, Viviane S.-
dc.contributor.authorGERBER, Viviane K. Q.-
dc.contributor.authorLICHT, Otavio A. B.-
dc.contributor.authorIBANEZ, Marilea V. C.-
dc.contributor.authorAGUIAR JUNIOR, Terencio R.-
dc.contributor.authorMELLO, Rosiane G.-
dc.contributor.authorKOMECHEN, Heloisa-
dc.contributor.authorANDRADE, Diancarlos P.-
dc.contributor.authorPICHARSKI, Gledson L.-
dc.contributor.authorFIGUEIREDO, Damasio P. G.-
dc.contributor.authorPIANOVSKI, Mara A. D.-
dc.contributor.authorFIGUEIREDO, Mirna M. O.-
dc.contributor.authorCUSTODIO, Gislaine-
dc.contributor.authorPARISE, Ivy Z. S.-
dc.contributor.authorCASTILHO, Laura M.-
dc.contributor.authorPARAIZO, Mariana M.-
dc.contributor.authorEDINGER, Chloe-
dc.contributor.authorFIORI, Carmem M. C. M.-
dc.contributor.authorPEDRINI, Helio-
dc.contributor.authorKIESEL FILHO, Nilton-
dc.contributor.authorFABRO, Ana Luiza M. R.-
dc.contributor.authorFACHIN, Rayssa D.-
dc.contributor.authorOGRADOWSKI, Karin R. P.-
dc.contributor.authorPARISE, Guilherme A.-
dc.contributor.authorSALDIVA, Paulo H. N.-
dc.contributor.authorLEGAL, Edith F.-
dc.contributor.authorROSATI, Roberto-
dc.contributor.authorRODRIGUEZ-GALINDO, Carlos-
dc.contributor.authorRIBEIRO, Raul C.-
dc.contributor.authorZAMBETTI, Gerard P.-
dc.contributor.authorLALLI, Enzo-
dc.contributor.authorFIGUEIREDO, Bonald C.-
dc.date.accessioned2018-11-21T17:06:22Z-
dc.date.available2018-11-21T17:06:22Z-
dc.date.issued2019-
dc.identifier.citationSCIENCE OF THE TOTAL ENVIRONMENT, v.650, p.1278-1291, 2019-
dc.identifier.issn0048-9697-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29569-
dc.description.abstractThe incidence of variable congenital malformation (CM) among 399 municipalities in the state of Parana, southern Brazil, suggests the etiological role of environmental factors. This study examined a) environmental concentrations of chlorine anions (Cl-) associated with organochlorines (OCs) and b) associations between these chemicals and agricultural output with CMs using a geographical information system. In one of the three years during the sampling period (2008, 2009 or 2010) Cl-, dichlorodiphenyltrichloroethane (p,p'-DDT), dichlorodiphenyldichloroethylene (p, p'-DDE), dichlorodiphenyldichloroethane (p,p'-DDD), and endosulfan levels were measured in 465 (465/736, 63%) catchment basins. Agricultural outputs for crops during 2006-2010 were also evaluated (t/km(2)). Further, CM kernel density for the 399 municipalities in Parana during 2007-2014 was investigated. Cl- levels increased significantly in one of the three years (2008, 2009 or 2010) in western catchment basins, compared to 1996 (p < 0.0001). The municipalities were divided according to the obtained Cl- levels, where sub-region C2 (central-southern) < 1.8mg/L <= sub-regions C1 (northern-western) and C3 (eastern-southern). We identified 8756 cases of CMs among 1,221,287 newborns (NB) in all sub-regions. C1 had higher DDT-DDE-DDD (p,p'-DDT + p,p'-DDE + p,p'-DDD) concentrations, agricultural output, and CM kernel density. C2 and C3 had minor agricultural outputs (per square kilometer) and CM densities. A 2.96 mg/L increase in Cl- between sub-regions C1 and C2 was co-localized with a 45% increase in CM density (spatial relative risk = 1.45, CI 95%: 1.36-1.55). C1 had the highest log likelihood ratios (p = 0.001) identified via SaTScan clustering analyses. Organochlorines and other toxic chlorinated chemicals may contribute to CMs in humans, and these chemicals are ultimately transformed and release Cl- in rivers. Higher Cl- levels were correlated significantly with higher agricultural productivity, DDT-DDE-DDD levels, and CMs in some parts of the northern and western sub-regions (C1). (C) 2018 Published by Elsevier B.V.-
dc.description.sponsorshipParana State Secretary of Science, Technology and Higher Education [026/06/SETI/Geomedicina]-
dc.description.sponsorshipBrazilian National Council for Research and Development (CNPq)-
dc.description.sponsorshipCoordenadoria de Aperfeicoamento de Pessoal de Ensino Superior (CAPES)-
dc.language.isoeng-
dc.publisherELSEVIER SCIENCE BV-
dc.relation.ispartofScience of the Total Environment-
dc.rightsrestrictedAccess-
dc.subjectAgricultural output-
dc.subjectPesticide-
dc.subjectOrganochlorine-
dc.subjectChloride-
dc.subjectCongenital anomaly-
dc.subjectSpatial analysis-
dc.subject.otherorganochlorine pesticides-
dc.subject.otherpolychlorinated-biphenyls-
dc.subject.otherddt-
dc.subject.otherexposure-
dc.subject.otheranomalies-
dc.subject.otherchildren-
dc.subject.otherdefects-
dc.subject.othermothers-
dc.subject.otherdioxins-
dc.subject.otherchina-
dc.titleSpatial trends in congenital malformations and stream water chemistry in Southern Brazil-
dc.typearticle-
dc.rights.holderCopyright ELSEVIER SCIENCE BV-
dc.identifier.doi10.1016/j.scitotenv.2018.09.061-
dc.identifier.pmid30308815
dc.subject.wosEnvironmental Sciences-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalIBANEZ, Humberto C.:Pele Pequeno Principe Res Inst, Curitiba, Parana, Brazil; Fac Pequeno Principe, Curitiba, Parana, Brazil-
hcfmusp.author.externalMELANDA, Viviane S.:Secretaria Estado Saude Parana, Dept Vigilancia Epidemiol, Curitiba, Parana, Brazil-
hcfmusp.author.externalGERBER, Viviane K. Q.:Pele Pequeno Principe Res Inst, Curitiba, Parana, Brazil; Fac Pequeno Principe, Curitiba, Parana, Brazil-
hcfmusp.author.externalLICHT, Otavio A. B.:Inst Terras Cartog & Geol, Curitiba, Parana, Brazil-
hcfmusp.author.externalIBANEZ, Marilea V. C.:Pele Pequeno Principe Res Inst, Curitiba, Parana, Brazil-
hcfmusp.author.externalAGUIAR JUNIOR, Terencio R.:Univ Fed Parana, Ctr Genet Mol & Pesquisa Canc Criancas CEGEMPAC, Curitiba, Parana, Brazil-
hcfmusp.author.externalMELLO, Rosiane G.:Pele Pequeno Principe Res Inst, Curitiba, Parana, Brazil; Fac Pequeno Principe, Curitiba, Parana, Brazil-
hcfmusp.author.externalKOMECHEN, Heloisa:Pele Pequeno Principe Res Inst, Curitiba, Parana, Brazil; Univ Fed Parana, Ctr Genet Mol & Pesquisa Canc Criancas CEGEMPAC, Curitiba, Parana, Brazil-
hcfmusp.author.externalANDRADE, Diancarlos P.:Pele Pequeno Principe Res Inst, Curitiba, Parana, Brazil; Fac Pequeno Principe, Curitiba, Parana, Brazil-
hcfmusp.author.externalPICHARSKI, Gledson L.:Pele Pequeno Principe Res Inst, Curitiba, Parana, Brazil; Fac Pequeno Principe, Curitiba, Parana, Brazil-
hcfmusp.author.externalFIGUEIREDO, Damasio P. G.:Univ Fed Parana, Ctr Genet Mol & Pesquisa Canc Criancas CEGEMPAC, Curitiba, Parana, Brazil-
hcfmusp.author.externalPIANOVSKI, Mara A. D.:Univ Fed Parana, Ctr Genet Mol & Pesquisa Canc Criancas CEGEMPAC, Curitiba, Parana, Brazil; Erasto Gaertner Hosp, Curitiba, Parana, Brazil-
hcfmusp.author.externalFIGUEIREDO, Mirna M. O.:Univ Fed Parana, Ctr Genet Mol & Pesquisa Canc Criancas CEGEMPAC, Curitiba, Parana, Brazil-
hcfmusp.author.externalCUSTODIO, Gislaine:Univ Fed Parana, Ctr Genet Mol & Pesquisa Canc Criancas CEGEMPAC, Curitiba, Parana, Brazil-
hcfmusp.author.externalPARISE, Ivy Z. S.:Pele Pequeno Principe Res Inst, Curitiba, Parana, Brazil; Fac Pequeno Principe, Curitiba, Parana, Brazil-
hcfmusp.author.externalCASTILHO, Laura M.:Pele Pequeno Principe Res Inst, Curitiba, Parana, Brazil-
hcfmusp.author.externalPARAIZO, Mariana M.:Pele Pequeno Principe Res Inst, Curitiba, Parana, Brazil; Fac Pequeno Principe, Curitiba, Parana, Brazil-
hcfmusp.author.externalEDINGER, Chloe:Pele Pequeno Principe Res Inst, Curitiba, Parana, Brazil-
hcfmusp.author.externalFIORI, Carmem M. C. M.:Uniao Oeste Paranaense Estudos & Combate Canc UOP, Cascavel, PR, Brazil; Univ Estadual Oeste Parana, Cascavel, PR, Brazil-
hcfmusp.author.externalPEDRINI, Helio:Inst Computacao Univ Campinas UNICAMP, Campinas, SP, Brazil; St Jude Childrens Res Hosp, Dept Global Pediat Med, 332 N Lauderdale St, Memphis, TN 38105 USA-
hcfmusp.author.externalKIESEL FILHO, Nilton:Hosp Pequeno Principe, Curitiba, Parana, Brazil-
hcfmusp.author.externalFABRO, Ana Luiza M. R.:Pele Pequeno Principe Res Inst, Curitiba, Parana, Brazil; Hosp Pequeno Principe, Curitiba, Parana, Brazil-
hcfmusp.author.externalFACHIN, Rayssa D.:Pele Pequeno Principe Res Inst, Curitiba, Parana, Brazil-
hcfmusp.author.externalOGRADOWSKI, Karin R. P.:Pele Pequeno Principe Res Inst, Curitiba, Parana, Brazil; Fac Pequeno Principe, Curitiba, Parana, Brazil-
hcfmusp.author.externalPARISE, Guilherme A.:Univ Fed Parana, Ctr Genet Mol & Pesquisa Canc Criancas CEGEMPAC, Curitiba, Parana, Brazil-
hcfmusp.author.externalLEGAL, Edith F.:Fac Pequeno Principe, Curitiba, Parana, Brazil-
hcfmusp.author.externalROSATI, Roberto:Pele Pequeno Principe Res Inst, Curitiba, Parana, Brazil; Fac Pequeno Principe, Curitiba, Parana, Brazil-
hcfmusp.author.externalRODRIGUEZ-GALINDO, Carlos:St Jude Childrens Res Hosp, Dept Global Pediat Med, 332 N Lauderdale St, Memphis, TN 38105 USA-
hcfmusp.author.externalRIBEIRO, Raul C.:Fac Pequeno Principe, Curitiba, Parana, Brazil; St Jude Childrens Res Hosp, Dept Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA-
hcfmusp.author.externalZAMBETTI, Gerard P.:St Jude Childrens Res Hosp, Dept Pathol, 332 N Lauderdale St, Memphis, TN 38105 USA-
hcfmusp.author.externalLALLI, Enzo:CNRS, Inst Pharmacol Mol & Cellulaire, 660 Route Lucioles, Valbonne, France-
hcfmusp.author.externalFIGUEIREDO, Bonald C.:Pele Pequeno Principe Res Inst, Curitiba, Parana, Brazil; Fac Pequeno Principe, Curitiba, Parana, Brazil; Univ Fed Parana, Ctr Genet Mol & Pesquisa Canc Criancas CEGEMPAC, Curitiba, Parana, Brazil; Univ Fed Parana, Dept Saude Colet, Curitiba, Parana, Brazil-
hcfmusp.description.beginpage1278-
hcfmusp.description.endpage1291-
hcfmusp.description.volume650-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000447092700129-
hcfmusp.origem.id2-s2.0-85053182889-
hcfmusp.publisher.cityAMSTERDAM-
hcfmusp.publisher.countryNETHERLANDS-
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