Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorOLIVEIRA, Antonio Anax Falcao de-
dc.contributor.authorOLIVEIRA, Tiago Franco de-
dc.contributor.authorDIAS, Michelle Francini-
dc.contributor.authorMEDEIROS, Marisa Helena Gennari-
dc.contributor.authorMASCIO, Paolo Di-
dc.contributor.authorVERAS, Mariana-
dc.contributor.authorLEMOS, Miriam-
dc.contributor.authorMARCOURAKIS, Tania-
dc.contributor.authorSALDIVA, Paulo Hilario Nascimento-
dc.contributor.authorLOUREIRO, Ana Paula Melo-
dc.identifier.citationPARTICLE AND FIBRE TOXICOLOGY, v.15, article ID 40, 19p, 2018-
dc.description.abstractBackgroundThe Metropolitan Area of SAo Paulo has a unique composition of atmospheric pollutants, and positive correlations between exposure and the risk of diseases and mortality have been observed. Here we assessed the effects of ambient fine particulate matter (PM2.5) on genotoxic and global DNA methylation and hydroxymethylation changes, as well as the activities of antioxidant enzymes, in tissues of AJ mice exposed whole body to ambient air enriched in PM2.5, which was concentrated in a chamber near an avenue of intense traffic in SAo Paulo City, Brazil.ResultsMice exposed to concentrated ambient PM2.5 (1h daily, 3months) were compared to in situ ambient air exposed mice as the study control. The concentrated PM2.5 exposed group presented increased levels of the oxidized nucleoside 8-oxo-7,8-dihydro-2-deoxyguanosine in lung and kidney DNA and increased levels of the etheno adducts 1,N-6-etheno-2-deoxyadenosine and 1,N-2-etheno-2-deoxyguanosine in kidney and liver DNA, respectively. Apart from the genotoxic effects, the exposure to PM2.5 led to decreased levels of the epigenetic mark 5-hydroxymethylcytosine (5-hmC) in lung and liver DNA. Changes in lung, liver, and erythrocyte antioxidant enzyme activities were also observed. Decreased glutathione reductase and increased superoxide dismutase (SOD) activities were observed in the lungs, while the liver presented increased glutathione S-transferase and decreased SOD activities. An increase in SOD activity was also observed in erythrocytes. These changes are consistent with the induction of local and systemic oxidative stress.ConclusionsMice exposed daily to PM2.5 at a concentration that mimics 24-h exposure to the mean concentration found in ambient air presented, after 3months, increased levels of DNA lesions related to the occurrence of oxidative stress in the lungs, liver, and kidney, in parallel to decreased global levels of 5-hmC in lung and liver DNA. Genetic and epigenetic alterations induced by pollutants may affect the genes committed to cell cycle control, apoptosis, and cell differentiation, increasing the chance of cancer development, which merits further investigation.-
dc.description.sponsorshipFAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [2012/22190-3, 2012/08616-8]-
dc.description.sponsorshipCNPq [454214/2014-6]-
dc.description.sponsorshipPRPUSP (Pro-Reitoria de Pesquisa da Universidade de Sao Paulo)-
dc.description.sponsorshipINCT INAIRA (MCT/CNPq/FNDCT/CAPES/FAPEMIG/FAPERJ/FAPESP) [573813/2008-6]-
dc.description.sponsorshipINCT Redoxoma (FAPESP/CNPq/CAPES) [573530/2008-4]-
dc.description.sponsorshipNAP Redoxoma (PRPUSP) [2011.1.9352.1.8]-
dc.description.sponsorshipCEPID Redoxoma (FAPESP) [2013/07937-8]-
dc.description.sponsorshipFAPESP [2012/21636-8, 2011/09891-0, 2012/08617-4]-
dc.description.sponsorshipCAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)-
dc.relation.ispartofParticle and Fibre Toxicology-
dc.subjectParticulate matter-
dc.subjectOxidative stress-
dc.subjectDNA adducts-
dc.subjectDNA methylation-
dc.subject.othertandem mass-spectrometry-
dc.subject.otherdiesel exhaust particles-
dc.subject.otherwhite blood-cells-
dc.subject.othershort-term exposure-
dc.subject.othercpg island shores-
dc.subject.otheroxidative stress-
dc.titleGenotoxic and epigenotoxic effects in mice exposed to concentrated ambient fine particulate matter (PM2.5) from SAo Paulo city, Brazil-
dc.rights.holderCopyright BMC-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Antonio Anax Falcao de:Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Ave Prof Lineu Prestes 580,Bloco 13 B, BR-05508000 Sao Paulo, Brazil-, Tiago Franco de:Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Ave Prof Lineu Prestes 580,Bloco 13 B, BR-05508000 Sao Paulo, Brazil; Univ Fed Ciencias Saude Porto Alegre, Dept Farmacociencias, Rua Sarmento Leite 245, BR-90050170 Porto Alegre, RS, Brazil-, Michelle Francini:Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Ave Prof Lineu Prestes 580,Bloco 13 B, BR-05508000 Sao Paulo, Brazil-, Marisa Helena Gennari:Univ Sao Paulo, Inst Quim, Dept Bioquim, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, Brazil-, Paolo Di:Univ Sao Paulo, Inst Quim, Dept Bioquim, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, Brazil-, Tania:Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Ave Prof Lineu Prestes 580,Bloco 13 B, BR-05508000 Sao Paulo, Brazil-, Ana Paula Melo:Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Ave Prof Lineu Prestes 580,Bloco 13 B, BR-05508000 Sao Paulo, Brazil-
hcfmusp.relation.referenceAEBI H, 1984, METHOD ENZYMOL, V105, P121-
hcfmusp.relation.referenceAlexander DJ, 2008, INHAL TOXICOL, V20, P1179, DOI [10.1080/08958370802207318, 10.1080/08958370802207318 ]-
hcfmusp.relation.referenceAlvarado-Cruz I, 2017, MUTAT RES-GEN TOX EN, V813, P27, DOI 10.1016/j.mrgentox.2016.11.007-
hcfmusp.relation.referenceAnderson LG, 2009, ENERG ENVIRON SCI, V2, P1015, DOI 10.1039/b906057j-
hcfmusp.relation.referenceAngeli JPF, 2011, FREE RADICAL BIO MED, V51, P503, DOI 10.1016/j.freeradbiomed.2011.04.015-
hcfmusp.relation.reference[Anonymous], 2016, IARC MON EV CARC RIS, P448-
hcfmusp.relation.referenceArab K, 2009, CARCINOGENESIS, V30, P282, DOI 10.1093/carcin/bgn264-
hcfmusp.relation.referenceBaccarelli A, 2009, AM J RESP CRIT CARE, V179, P572, DOI 10.1164/rccm.200807-1097OC-
hcfmusp.relation.referenceBakulski KM, 2014, ENVIRON MOL MUTAGEN, V55, P171, DOI 10.1002/em.21850-
hcfmusp.relation.referenceCarvalho VSB, 2015, ENVIRON SCI POLICY, V47, P68, DOI 10.1016/j.envsci.2014.11.001-
hcfmusp.relation.referenceBartosz G, 2009, BIOCHEM PHARMACOL, V77, P1303, DOI 10.1016/j.bcp.2008.11.009-
hcfmusp.relation.referenceBartsch H, 2000, EUR J CANCER, V36, P1229, DOI 10.1016/S0959-8049(00)00095-2-
hcfmusp.relation.referenceBell ML, 2007, ENVIRON HEALTH PERSP, V115, P989, DOI 10.1289/ehp.9621-
hcfmusp.relation.referenceBellavia A, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.113.000212-
hcfmusp.relation.referenceBenbrahim-Tallaa L, 2012, LANCET ONCOL, V13, P663, DOI 10.1016/S1470-2045(12)70280-2-
hcfmusp.relation.referenceBender J, 2004, ANNU REV PLANT BIOL, V55, P41, DOI 10.1146/annurev.arplant.55.031903.141641-
hcfmusp.relation.referenceBock C, 2016, NAT BIOTECHNOL, V34, P726, DOI 10.1038/nbt.3605-
hcfmusp.relation.referenceBranco MR, 2012, NAT REV GENET, V13, P7, DOI 10.1038/nrg3080-
hcfmusp.relation.referenceBrenet F, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0014524-
hcfmusp.relation.referenceBrook RD, 2010, CIRCULATION, V121, P2331, DOI 10.1161/CIR.0b013e3181dbece1-
hcfmusp.relation.referenceCadet J, 2012, FREE RADICAL RES, V46, P367, DOI 10.3109/10715762.2012.659248-
hcfmusp.relation.referenceCai J, 2017, SCI TOTAL ENVIRON, V607, P1103, DOI 10.1016/j.scitotenv.2017.07.029-
hcfmusp.relation.referenceCalderon-Garciduenas L, 1999, ENVIRON HEALTH PERSP, V107, P469, DOI 10.2307/3434629-
hcfmusp.relation.referenceCARLBERG I, 1975, J BIOL CHEM, V250, P5475-
hcfmusp.relation.referenceCETESB-Companhia Ambiental do Estado de SAo Paulo, 2010, QUAL SIST INF QUAL A-
hcfmusp.relation.referenceCETESB-Companhia Ambiental do Estado de SAo Paulo, 2013, QUAL EST SAO PAUL 20-
hcfmusp.relation.referenceChappell G, 2016, MUTAT RES-REV MUTAT, V768, P27, DOI 10.1016/j.mrrev.2016.03.004-
hcfmusp.relation.referenceChen HJC, 2011, ANAL CHEM, V83, P8543, DOI 10.1021/ac201874d-
hcfmusp.relation.referenceChen RJ, 2016, ENVIRON INT, V94, P614, DOI 10.1016/j.envint.2016.06.026-
hcfmusp.relation.referenceChen WL, 2014, MOL BIOSYST, V10, P3163, DOI 10.1039/c4mb00435c-
hcfmusp.relation.referenceChurchwell MI, 2002, CHEM RES TOXICOL, V15, P1295, DOI 10.1021/tx0101595-
hcfmusp.relation.referenceCollins A, 2002, CARCINOGENESIS, V23, P2129-
hcfmusp.relation.referenceCui SW, 2014, INT J ENV RES PUB HE, V11, P10902, DOI 10.3390/ijerph111010902-
hcfmusp.relation.referenceDahl C, 2011, CLIN CHIM ACTA, V412, P831, DOI 10.1016/j.cca.2011.02.013-
hcfmusp.relation.referenceDamiani LA, 2008, CANCER RES, V68, P9005, DOI 10.1158/0008-5472.CAN-08-1276-
hcfmusp.relation.referenceDanielsen PH, 2011, CHEM RES TOXICOL, V24, P168, DOI 10.1021/tx100407m-
hcfmusp.relation.referenceDanielsen PH, 2010, TOXICOL SCI, V118, P574, DOI 10.1093/toxsci/kfq290-
hcfmusp.relation.referencede Kok TM, 2005, ENVIRON MOL MUTAGEN, V46, P71, DOI 10.1002/em.20133-
hcfmusp.relation.referenceDe Martinis BS, 1999, MUTAT RES-GEN TOX EN, V446, P83-
hcfmusp.relation.referenceDe Nys S, 2018, ENVIRON INT, V111, P301, DOI 10.1016/j.envint.2017.11.002-
hcfmusp.relation.referenceDe Prins S, 2013, ENVIRON INT, V59, P418, DOI 10.1016/j.envint.2013.07.007-
hcfmusp.relation.referenceDechakhamphu S, 2010, CANCER EPIDEM BIOMAR, V19, P310, DOI 10.1158/1055-9965.EPI-09-0849-
hcfmusp.relation.referenceDelatte B, 2015, SCI REP-UK, V5, DOI 10.1038/srep12714-
hcfmusp.relation.referenceDeMarini DM, 2013, MUTAGENESIS, V28, P485, DOI 10.1093/mutage/get042-
hcfmusp.relation.referenceDeMarini DM, 2001, CANCER RES, V61, P6679-
hcfmusp.relation.referenceDemetriou CA, 2012, OCCUP ENVIRON MED, V69, P619, DOI 10.1136/oemed-2011-100566-
hcfmusp.relation.referenceDing R, 2016, MUTAT RES-GEN TOX EN, V796, P46, DOI 10.1016/j.mrgentox.2015.12.002-
hcfmusp.relation.referenceDoerge DR, 2000, CHEM RES TOXICOL, V13, P1259, DOI 10.1021/tx0001575-
hcfmusp.relation.referenceDoi A, 2009, NAT GENET, V41, P1350, DOI 10.1038/ng.471-
hcfmusp.relation.referenceDybdahl M, 2004, MUTAT RES-GEN TOX EN, V562, P119, DOI 10.1016/j.mrgentox.2004.05.010-
hcfmusp.relation.referenceFajersztajn L, 2013, NAT REV CANCER, V13, P674, DOI 10.1038/nrc3572-
hcfmusp.relation.referenceFeil R, 2012, NAT REV GENET, V13, P97, DOI 10.1038/nrg3142-
hcfmusp.relation.referenceFLOHE L, 1984, METHOD ENZYMOL, V105, P114-
hcfmusp.relation.referenceFLOHE L, 1984, METHOD ENZYMOL, V105, P93-
hcfmusp.relation.referenceForman HJ, 2014, J MOL CELL CARDIOL, V73, P2, DOI 10.1016/j.yjmcc.2014.01.018-
hcfmusp.relation.referenceGarcia CCM, 2013, CHEM RES TOXICOL, V26, P1602, DOI 10.1021/tx400273q-
hcfmusp.relation.referenceGarcia CCM, 2010, CHEM RES TOXICOL, V23, P1851, DOI 10.1021/tx100339e-
hcfmusp.relation.referenceGarcia CCM, 2011, J AM CHEM SOC, V133, P9140, DOI 10.1021/ja2004686-
hcfmusp.relation.referenceGodschalk R, 2002, CARCINOGENESIS, V23, P2081, DOI 10.1093/carcin/23.12.2081-
hcfmusp.relation.referenceGuo LQ, 2014, ENVIRON MOL MUTAGEN, V55, P322, DOI 10.1002/em.21838-
hcfmusp.relation.referenceGutierrez-Castillo ME, 2006, ENVIRON MOL MUTAGEN, V47, P199, DOI 10.1002/em.20186-
hcfmusp.relation.referenceHABIG WH, 1974, P NATL ACAD SCI USA, V71, P3879, DOI 10.1073/pnas.71.10.3879-
hcfmusp.relation.referenceHaffner MC, 2011, ONCOTARGET, V2, P627-
hcfmusp.relation.referenceHalliwell B., 2007, FREE RADICALS BIOL M-
hcfmusp.relation.referenceHelbock HJ, 1998, P NATL ACAD SCI USA, V95, P288, DOI 10.1073/pnas.95.1.288-
hcfmusp.relation.referenceHellack B, 2015, ATMOS ENVIRON, V105, P1, DOI 10.1016/j.atmosenv.2015.01.033-
hcfmusp.relation.referenceHerceg Z, 2011, EPIGENETICS-US, V6, P804, DOI 10.4161/epi.6.7.16262-
hcfmusp.relation.referenceHillestrom PR, 2006, J AM SOC MASS SPECTR, V17, P605, DOI 10.1016/j.jasms.2005.12.012-
hcfmusp.relation.referenceHofer T, 2006, BIOL CHEM, V387, P103, DOI 10.1515/BC.2006.014-
hcfmusp.relation.referenceHou LF, 2014, ENVIRON MOL MUTAGEN, V55, P256, DOI 10.1002/em.21829-
hcfmusp.relation.referenceIchinose T, 1997, CARCINOGENESIS, V18, P185, DOI 10.1093/carcin/18.1.185-
hcfmusp.relation.referenceIrizarry RA, 2009, NAT GENET, V41, P178, DOI 10.1038/ng.298-
hcfmusp.relation.referenceIwai K, 2000, ENVIRON RES, V84, P255, DOI 10.1006/enrs.2000.4072-
hcfmusp.relation.referenceJanssen BG, 2013, PART FIBRE TOXICOL, V10, DOI 10.1186/1743-8977-10-22-
hcfmusp.relation.referenceJi H, 2012, J ALLERGY CLIN IMMUN, V129, P33, DOI 10.1016/j.jaci.2011.11.008-
hcfmusp.relation.referenceJiang CL, 2017, ONCOTARGET, V8, P1369, DOI 10.18632/oncotarget.13622-
hcfmusp.relation.referenceJin ZL, 2018, GENES DIS, V5, P1, DOI 10.1016/j.gendis.2018.01.002-
hcfmusp.relation.referenceKampfrath T, 2011, CIRC RES, V108, P716, DOI 10.1161/CIRCRESAHA.110.237560-
hcfmusp.relation.referenceKarlsson HL, 2004, MUTAT RES-GEN TOX EN, V565, P1, DOI 10.1016/j.mrgentox.2004.07.015-
hcfmusp.relation.referenceKe SR, 2018, TOXICOL LETT, V290, P10, DOI 10.1016/j.toxlet.2018.03.005-
hcfmusp.relation.referenceKim JY, 2004, ENVIRON HEALTH PERSP, V112, P666, DOI 10.1289/ehp.6827-
hcfmusp.relation.referenceKim S, 2000, INHAL TOXICOL, V12, P281, DOI 10.1080/089583700750019611-
hcfmusp.relation.referenceKnaapen AM, 2006, MUTAGENESIS, V21, P225, DOI 10.1093/mutage/gel032-
hcfmusp.relation.referenceLee S, 2013, ANTIOXID REDOX SIGN, V18, P1165, DOI 10.1089/ars.2011.4322-
hcfmusp.relation.referenceLisanti S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079044-
hcfmusp.relation.referenceLoft S, 2012, FREE RADICAL BIO MED, V52, P167, DOI 10.1016/j.freeradbiomed.2011.10.439-
hcfmusp.relation.referenceLoureiro APM, 2000, CHEM RES TOXICOL, V13, P601, DOI 10.1021/tx000004h-
hcfmusp.relation.referenceLoureiro APM, 2002, CHEM RES TOXICOL, V15, P1302, DOI 10.1021/tx025554p-
hcfmusp.relation.referenceMadrigano J, 2011, ENVIRON HEALTH PERSP, V119, P977, DOI 10.1289/ehp.1002773-
hcfmusp.relation.referenceMagalhaes D, 2007, QUIM NOVA, V30, P577, DOI 10.1590/S0100-40422007000300014-
hcfmusp.relation.referenceMagana AA, 2008, ANAL BIOCHEM, V374, P378, DOI 10.1016/j.ab.2007.11.026-
hcfmusp.relation.referenceMagnani ND, 2011, BIOCHEM BIOPH RES CO, V412, P667, DOI 10.1016/j.bbrc.2011.08.021-
hcfmusp.relation.referenceMangal D, 2009, CHEM RES TOXICOL, V22, P788, DOI 10.1021/tx800343c-
hcfmusp.relation.referenceMarie-Desvergne C, 2010, CHEM RES TOXICOL, V23, P1207, DOI 10.1021/tx100081p-
hcfmusp.relation.referenceMarnett LJ, 2001, TRENDS GENET, V17, P214, DOI 10.1016/S0168-9525(01)02239-9-
hcfmusp.relation.referenceMartins LD, 2010, AIR QUAL ATMOS HLTH, V3, P29, DOI 10.1007/s11869-009-0048-9-
hcfmusp.relation.referenceMauad T, 2008, AM J RESP CRIT CARE, V178, P721, DOI 10.1164/rccm.200803-436OC-
hcfmusp.relation.referenceMCCORD JM, 1969, J BIOL CHEM, V244, P6056-
hcfmusp.relation.referenceMedeiros MHG, 2009, CHEM RES TOXICOL, V22, P419, DOI 10.1021/tx800367d-
hcfmusp.relation.referenceMENACHE MG, 1995, ANN OCCUP HYG, V39, P317, DOI 10.1093/annhyg/39.3.317-
hcfmusp.relation.referenceMeng Z, 2007, FOOD CHEM TOXICOL, V45, P1368, DOI 10.1016/j.fet.2007.01.014-
hcfmusp.relation.referenceMoller P, 2012, CURR MOL MED, V12, P732, DOI 10.2174/156652412800792624-
hcfmusp.relation.referenceMoller P, 2008, CANCER LETT, V266, P84, DOI 10.1016/j.canlet.2008.02.030-
hcfmusp.relation.referenceMoller P, 2014, MUTAT RES-REV MUTAT, V762, P133, DOI 10.1016/j.mrrev.2014.09.001-
hcfmusp.relation.referenceMonien BH, 2015, ANAL CHEM, V87, P641, DOI 10.1021/ac503803m-
hcfmusp.relation.referenceNair J, 1997, CANCER EPIDEM BIOMAR, V6, P597-
hcfmusp.relation.referenceNair U, 2007, FREE RADICAL BIO MED, V43, P1109, DOI 10.1016/j.freeradbiomed.2007.07.012-
hcfmusp.relation.referenceNogueira T, 2015, ATMOS ENVIRON, V108, P88, DOI 10.1016/j.atmosenv.2015.02.064-
hcfmusp.relation.referenceObtulowicz T, 2010, MUTAGENESIS, V25, P463, DOI 10.1093/mutage/geq028-
hcfmusp.relation.referencePang B, 2007, CARCINOGENESIS, V28, P1807, DOI 10.1093/carein/bgm037-
hcfmusp.relation.referencePope CA, 2006, J AIR WASTE MANAGE, V56, P709, DOI 10.1080/10473289.2006.10464485-
hcfmusp.relation.referenceQin M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046856-
hcfmusp.relation.referenceRaaschou-Nielsen O, 2013, LANCET ONCOL, V14, P813, DOI 10.1016/S1470-2045(13)70279-1-
hcfmusp.relation.referenceRisom L, 2005, MUTAT RES-FUND MOL M, V592, P119, DOI 10.1016/j.mrfmmm.2005.06.012-
hcfmusp.relation.referenceRisom L, 2003, CARCINOGENESIS, V24, P1847, DOI 10.1093/carcin/bgg144-
hcfmusp.relation.referenceRisom L, 2007, FREE RADICAL RES, V41, P172, DOI 10.1080/10715760601024122-
hcfmusp.relation.referenceRiva DR, 2011, INHAL TOXICOL, V23, P257, DOI 10.3109/08958378.2011.566290-
hcfmusp.relation.referenceRobertson KD, 2000, NAT REV GENET, V1, P11, DOI 10.1038/35049533-
hcfmusp.relation.referenceRossner P, 2010, TOXICOL LETT, V198, P312, DOI 10.1016/j.toxlet.2010.06.021-
hcfmusp.relation.referenceSamet JM, 2014, SALUD PUBLICA MEXICO, V56, P379-
hcfmusp.relation.referenceSanchez-Guerra M, 2015, EPIGENETICS-US, V10, P633, DOI 10.1080/15592294.2015.1050174-
hcfmusp.relation.referenceSandhu J, 2009, J CHROMATOGR B, V877, P1957, DOI 10.1016/j.jchromb.2009.05.032-
hcfmusp.relation.referenceSchauer JJ., 2006, RES REP HLTH EFF I, V133, P77-
hcfmusp.relation.referenceSchmerold I, 2001, EXP GERONTOL, V36, P1375, DOI 10.1016/S0531-5565(01)00103-6-
hcfmusp.relation.referenceSharma S, 2010, CARCINOGENESIS, V31, P27, DOI 10.1093/carcin/bgp220-
hcfmusp.relation.referenceSilveyra P, 2012, SWISS MED WKLY, V142, DOI 10.4414/smw.2012.13579-
hcfmusp.relation.referenceSmith ZD, 2013, NAT REV GENET, V14, P204, DOI 10.1038/nrg3354-
hcfmusp.relation.referenceSomineni HK, 2016, J ALLERGY CLIN IMMUN, V137, P797, DOI 10.1016/j.jaci.2015.10.021-
hcfmusp.relation.referenceSorensen M, 2003, CANCER EPIDEM BIOMAR, V12, P191-
hcfmusp.relation.referenceTammen SA, 2014, ALCOHOL CLIN EXP RES, V38, P2178, DOI 10.1111/acer.12477-
hcfmusp.relation.referenceTan CC, 2017, SCI TOTAL ENVIRON, V593, P330, DOI 10.1016/j.scitotenv.2017.03.179-
hcfmusp.relation.referenceTarantini L, 2009, ENVIRON HEALTH PERSP, V117, P217, DOI 10.1289/ehp.11898-
hcfmusp.relation.referenceTeneng I, 2011, EPIGENETICS-US, V6, P355, DOI 10.4161/epi.6.3.14282-
hcfmusp.relation.referenceTsurudome Y, 1999, CARCINOGENESIS, V20, P1573, DOI 10.1093/carcin/20.8.1573-
hcfmusp.relation.referenceValavanidis A, 2005, REDOX REP, V10, P37, DOI 10.1179/135100005X21606-
hcfmusp.relation.referenceVeras MM, 2009, ENVIRON RES, V109, P536, DOI 10.1016/j.envres.2009.03.006-
hcfmusp.relation.referenceWei YJ, 2009, ENVIRON SCI TECHNOL, V43, P4757, DOI 10.1021/es803337c-
hcfmusp.relation.referenceWilliams K, 2012, EMBO REP, V13, P28, DOI 10.1038/embor.2011.233-
hcfmusp.relation.referenceWorld Health Organization, 2005, WHO AIR QUAL GUID PA-
hcfmusp.relation.referenceXia B, 2016, INT J TOXICOL, V35, P336, DOI 10.1177/1091581816637071-
hcfmusp.relation.referenceYanagi Y, 2012, CAD SAUDE PUBLICA, V28, P1737, DOI 10.1590/S0102-311X2012000900012-
hcfmusp.relation.referenceYauk C, 2008, P NATL ACAD SCI USA, V105, P605, DOI 10.1073/pnas.0705896105-
hcfmusp.relation.referenceAkinaga LMY, 2009, TOXICOL PATHOL, V37, P306, DOI 10.1177/0192623309332994-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/05
LIM/05 - Laboratório de Poluição Atmosférica Experimental

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

Artigos e Materiais de Revistas Científicas - ODS/11
ODS/11 - Cidades e comunidades sustentáveis

Files in This Item:
File Description SizeFormat 
art_OLIVEIRA_Genotoxic_and_epigenotoxic_effects_in_mice_exposed_to_2018.PDFpublishedVersion (English)1.12 MBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.