Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/29592
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorOLIVEIRA, Antonio Anax Falcao de-
dc.contributor.authorOLIVEIRA, Tiago Franco de-
dc.contributor.authorDIAS, Michelle Francini-
dc.contributor.authorMEDEIROS, Marisa Helena Gennari-
dc.contributor.authorMASCIO, Paolo Di-
dc.contributor.authorVERAS, Mariana-
dc.contributor.authorLEMOS, Miriam-
dc.contributor.authorMARCOURAKIS, Tania-
dc.contributor.authorSALDIVA, Paulo Hilario Nascimento-
dc.contributor.authorLOUREIRO, Ana Paula Melo-
dc.date.accessioned2018-11-21T17:06:25Z-
dc.date.available2018-11-21T17:06:25Z-
dc.date.issued2018-
dc.identifier.citationPARTICLE AND FIBRE TOXICOLOGY, v.15, article ID 40, 19p, 2018-
dc.identifier.issn1743-8977-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29592-
dc.description.abstractBackgroundThe Metropolitan Area of SAo Paulo has a unique composition of atmospheric pollutants, and positive correlations between exposure and the risk of diseases and mortality have been observed. Here we assessed the effects of ambient fine particulate matter (PM2.5) on genotoxic and global DNA methylation and hydroxymethylation changes, as well as the activities of antioxidant enzymes, in tissues of AJ mice exposed whole body to ambient air enriched in PM2.5, which was concentrated in a chamber near an avenue of intense traffic in SAo Paulo City, Brazil.ResultsMice exposed to concentrated ambient PM2.5 (1h daily, 3months) were compared to in situ ambient air exposed mice as the study control. The concentrated PM2.5 exposed group presented increased levels of the oxidized nucleoside 8-oxo-7,8-dihydro-2-deoxyguanosine in lung and kidney DNA and increased levels of the etheno adducts 1,N-6-etheno-2-deoxyadenosine and 1,N-2-etheno-2-deoxyguanosine in kidney and liver DNA, respectively. Apart from the genotoxic effects, the exposure to PM2.5 led to decreased levels of the epigenetic mark 5-hydroxymethylcytosine (5-hmC) in lung and liver DNA. Changes in lung, liver, and erythrocyte antioxidant enzyme activities were also observed. Decreased glutathione reductase and increased superoxide dismutase (SOD) activities were observed in the lungs, while the liver presented increased glutathione S-transferase and decreased SOD activities. An increase in SOD activity was also observed in erythrocytes. These changes are consistent with the induction of local and systemic oxidative stress.ConclusionsMice exposed daily to PM2.5 at a concentration that mimics 24-h exposure to the mean concentration found in ambient air presented, after 3months, increased levels of DNA lesions related to the occurrence of oxidative stress in the lungs, liver, and kidney, in parallel to decreased global levels of 5-hmC in lung and liver DNA. Genetic and epigenetic alterations induced by pollutants may affect the genes committed to cell cycle control, apoptosis, and cell differentiation, increasing the chance of cancer development, which merits further investigation.-
dc.description.sponsorshipFAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [2012/22190-3, 2012/08616-8]-
dc.description.sponsorshipCNPq [454214/2014-6]-
dc.description.sponsorshipCAPES-
dc.description.sponsorshipPRPUSP (Pro-Reitoria de Pesquisa da Universidade de Sao Paulo)-
dc.description.sponsorshipINCT INAIRA (MCT/CNPq/FNDCT/CAPES/FAPEMIG/FAPERJ/FAPESP) [573813/2008-6]-
dc.description.sponsorshipINCT Redoxoma (FAPESP/CNPq/CAPES) [573530/2008-4]-
dc.description.sponsorshipNAP Redoxoma (PRPUSP) [2011.1.9352.1.8]-
dc.description.sponsorshipCEPID Redoxoma (FAPESP) [2013/07937-8]-
dc.description.sponsorshipFAPESP [2012/21636-8, 2011/09891-0, 2012/08617-4]-
dc.description.sponsorshipCAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)-
dc.description.sponsorshipCNPq-
dc.language.isoeng-
dc.publisherBMC-
dc.relation.ispartofParticle and Fibre Toxicology-
dc.rightsopenAccess-
dc.subjectParticulate matter-
dc.subjectOxidative stress-
dc.subjectDNA adducts-
dc.subjectDNA methylation-
dc.subject.othertandem mass-spectrometry-
dc.subject.otherdiesel exhaust particles-
dc.subject.otheretheno-dna-adducts-
dc.subject.otherwhite blood-cells-
dc.subject.othershort-term exposure-
dc.subject.othercpg island shores-
dc.subject.otherair-pollution-
dc.subject.otheroxidative stress-
dc.subject.otherliquid-chromatography-
dc.subject.otherlung-cancer-
dc.titleGenotoxic and epigenotoxic effects in mice exposed to concentrated ambient fine particulate matter (PM2.5) from SAo Paulo city, Brazil-
dc.typearticle-
dc.rights.holderCopyright BMC-
dc.identifier.doi10.1186/s12989-018-0276-y-
dc.identifier.pmid30340610
dc.subject.wosToxicology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalOLIVEIRA, Antonio Anax Falcao de:Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Ave Prof Lineu Prestes 580,Bloco 13 B, BR-05508000 Sao Paulo, Brazil-
hcfmusp.author.externalOLIVEIRA, Tiago Franco de:Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Ave Prof Lineu Prestes 580,Bloco 13 B, BR-05508000 Sao Paulo, Brazil; Univ Fed Ciencias Saude Porto Alegre, Dept Farmacociencias, Rua Sarmento Leite 245, BR-90050170 Porto Alegre, RS, Brazil-
hcfmusp.author.externalDIAS, Michelle Francini:Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Ave Prof Lineu Prestes 580,Bloco 13 B, BR-05508000 Sao Paulo, Brazil-
hcfmusp.author.externalMEDEIROS, Marisa Helena Gennari:Univ Sao Paulo, Inst Quim, Dept Bioquim, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, Brazil-
hcfmusp.author.externalMASCIO, Paolo Di:Univ Sao Paulo, Inst Quim, Dept Bioquim, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, Brazil-
hcfmusp.author.externalMARCOURAKIS, Tania:Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Ave Prof Lineu Prestes 580,Bloco 13 B, BR-05508000 Sao Paulo, Brazil-
hcfmusp.author.externalLOUREIRO, Ana Paula Melo:Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Ave Prof Lineu Prestes 580,Bloco 13 B, BR-05508000 Sao Paulo, Brazil-
hcfmusp.description.articlenumber40-
hcfmusp.description.volume15-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000447845200002-
hcfmusp.origem.id2-s2.0-85055078429-
hcfmusp.publisher.cityLONDON-
hcfmusp.publisher.countryENGLAND-
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dc.description.indexMEDLINE-
hcfmusp.citation.scopus39-
hcfmusp.scopus.lastupdate2022-06-16-
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