Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/29602
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorNEUMANN, Anna-
dc.contributor.authorHASCHKA, Judith-
dc.contributor.authorKLEYER, Arnd-
dc.contributor.authorSCHUSTER, Louis-
dc.contributor.authorENGLBRECHT, Matthias-
dc.contributor.authorBERLIN, Andreas-
dc.contributor.authorFIGUEIREDO, Camille P.-
dc.contributor.authorSIMON, David-
dc.contributor.authorMUSCHITZ, Christian-
dc.contributor.authorKOCIJAN, Roland-
dc.contributor.authorRESCH, Heinrich-
dc.contributor.authorRECH, Juergen-
dc.contributor.authorSCHETT, Georg-
dc.date.accessioned2018-11-21T17:06:44Z-
dc.date.available2018-11-21T17:06:44Z-
dc.date.issued2018-
dc.identifier.citationARTHRITIS RESEARCH & THERAPY, v.20, article ID 202, 11p, 2018-
dc.identifier.issn1478-6354-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29602-
dc.description.abstractBackground: In the present study, we investigated bone geometry, microstructure, and volumetric bone mineral density (vBMD) in a cohort of patients with nonradiographic axial spondyloarthritis (nr-axSpA) in order to define the early bone changes occurring in axial spondyloarthritis (axSpA) and to define potential factors for deterioration of bone microstructure. Methods: Patients with axSpA (n = 107) and healthy control subjects (n = 50) of similar age and sex were assessed for geometric, volumetric, and microstructural parameters of bone using high-resolution peripheral quantitative computed tomography (HR-pQCT) at the radius. Additionally, demographic and disease-specific characteristics of patients with axSpA were recorded. Results: Patients with nr-axSpA and control subjects were comparable in age, sex, and body mass index. Geometric and microstructural analysis by HR-pQCT revealed a significantly reduced cortical area (p = 0.022) and cortical thickness (p = 0.006) in patients with nr-axSpA compared with control subjects. Total and cortical vBMD were significantly reduced in patients with nr-axSpA (p=0.042 and p = 0.007, respectively), whereas there was no difference in trabecular vBMD. Patients with a short disease duration (< 2 years; n = 46) also showed significant reduction of cortical thickness and cortical area compared with control subjects. Patients with disease duration > 2 years (n = 55) additionally developed a decrease of cortical and total vBMD. Multiple regression models identified male sex to be associated with lower cortical vBMD and female sex to be associated with lower trabecular vBMD. Conclusions: Bone microstructure in patients with nr-axSpA is characterized primarily by deterioration of cortical bone. Cortical bone loss starts early and is evident within the first 2 years of the disease.-
dc.description.sponsorshipDeutsche Forschungsgemeinschaft [CRC1181]-
dc.description.sponsorshipBundesministerium fur Bildung und Forschung (BMBF-
dc.description.sponsorshipproject METARTHROS)-
dc.description.sponsorshipInnovative Medicine Initiative-funded project Rheuma Tolerance for Cure (RTCure)-
dc.language.isoeng-
dc.publisherBMC-
dc.relation.ispartofArthritis Research & Therapy-
dc.rightsopenAccess-
dc.subjectSpondyloarthritis-
dc.subjectBone loss-
dc.subjectComputed tomography-
dc.subject.otherquantitative computed-tomography-
dc.subject.otherpsoriatic-arthritis patients-
dc.subject.otherin-vivo assessment-
dc.subject.otherankylosing-spondylitis-
dc.subject.othermineral density-
dc.subject.otherrheumatoid-arthritis-
dc.subject.otherpostmenopausal women-
dc.subject.othertrabecular plates-
dc.subject.otherstrength-
dc.subject.othermicroarchitecture-
dc.titleCortical bone loss is an early feature of nonradiographic axial spondyloarthritis-
dc.typearticle-
dc.rights.holderCopyright BMC-
dc.identifier.doi10.1186/s13075-018-1620-1-
dc.identifier.pmid30165891
dc.subject.wosRheumatology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalNEUMANN, Anna:Friedrich Alexander Univ Erlangen Nurnberg, Dept Internal Med 3, Ulmenweg 18, D-91054 Erlangen, Germany; Univ Klinikum Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany-
hcfmusp.author.externalHASCHKA, Judith:Friedrich Alexander Univ Erlangen Nurnberg, Dept Internal Med 3, Ulmenweg 18, D-91054 Erlangen, Germany; Univ Klinikum Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany; Med Univ Vienna, St Vincent Hosp, VINFORCE Study Grp, Vienna, Austria-
hcfmusp.author.externalKLEYER, Arnd:Friedrich Alexander Univ Erlangen Nurnberg, Dept Internal Med 3, Ulmenweg 18, D-91054 Erlangen, Germany; Univ Klinikum Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany-
hcfmusp.author.externalSCHUSTER, Louis:Friedrich Alexander Univ Erlangen Nurnberg, Dept Internal Med 3, Ulmenweg 18, D-91054 Erlangen, Germany; Univ Klinikum Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany-
hcfmusp.author.externalENGLBRECHT, Matthias:Friedrich Alexander Univ Erlangen Nurnberg, Dept Internal Med 3, Ulmenweg 18, D-91054 Erlangen, Germany; Univ Klinikum Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany-
hcfmusp.author.externalBERLIN, Andreas:Friedrich Alexander Univ Erlangen Nurnberg, Dept Internal Med 3, Ulmenweg 18, D-91054 Erlangen, Germany; Univ Klinikum Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany-
hcfmusp.author.externalSIMON, David:Friedrich Alexander Univ Erlangen Nurnberg, Dept Internal Med 3, Ulmenweg 18, D-91054 Erlangen, Germany; Univ Klinikum Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany-
hcfmusp.author.externalMUSCHITZ, Christian:Med Univ Vienna, St Vincent Hosp, VINFORCE Study Grp, Vienna, Austria-
hcfmusp.author.externalKOCIJAN, Roland:Med Univ Vienna, St Vincent Hosp, VINFORCE Study Grp, Vienna, Austria-
hcfmusp.author.externalRESCH, Heinrich:Med Univ Vienna, St Vincent Hosp, VINFORCE Study Grp, Vienna, Austria-
hcfmusp.author.externalRECH, Juergen:Friedrich Alexander Univ Erlangen Nurnberg, Dept Internal Med 3, Ulmenweg 18, D-91054 Erlangen, Germany; Univ Klinikum Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany-
hcfmusp.author.externalSCHETT, Georg:Friedrich Alexander Univ Erlangen Nurnberg, Dept Internal Med 3, Ulmenweg 18, D-91054 Erlangen, Germany; Univ Klinikum Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany-
hcfmusp.description.articlenumber202-
hcfmusp.description.volume20-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000443363100001-
hcfmusp.origem.id2-s2.0-85052593278-
hcfmusp.publisher.cityLONDON-
hcfmusp.publisher.countryENGLAND-
hcfmusp.relation.referenceAkgol G, 2014, RHEUMATOLOGY, V53, P497, DOI 10.1093/rheumatology/ket385-
hcfmusp.relation.referenceAllali F, 2003, ANN RHEUM DIS, V62, P347, DOI 10.1136/ard.62.4.347-
hcfmusp.relation.referenceAmstrup AK, 2016, J BONE MINER METAB, V34, P638, DOI 10.1007/s00774-015-0708-9-
hcfmusp.relation.referenceArends S, 2012, ARTHRITIS RES THER, V14, DOI 10.1186/ar3823-
hcfmusp.relation.referenceBoutroy S, 2005, J CLIN ENDOCR METAB, V90, P6508, DOI 10.1210/jc.2005-1258-
hcfmusp.relation.referenceBriot K, 2013, ANN RHEUM DIS, V72, P1914, DOI 10.1136/annrheumdis-2012-201845-
hcfmusp.relation.referenceCARTER DR, 1984, CALCIFIED TISSUE INT, V36, pS19, DOI 10.1007/BF02406129-
hcfmusp.relation.referenceCheung AM, 2013, CURR OSTEOPOROS REP, V11, P136, DOI 10.1007/s11914-013-0140-9-
hcfmusp.relation.referencede Waard EAC, 2018, CALCIFIED TISSUE INT, V103, P252, DOI 10.1007/s00223-018-0416-2-
hcfmusp.relation.referenceDEVOGELAER JP, 1992, ARTHRITIS RHEUM, V35, P1062, DOI 10.1002/art.1780350911-
hcfmusp.relation.referenceDONNELLY S, 1994, ANN RHEUM DIS, V53, P117, DOI 10.1136/ard.53.2.117-
hcfmusp.relation.referenceEngelke K, 2013, CURR OSTEOPOROS REP, V11, P246, DOI 10.1007/s11914-013-0147-2-
hcfmusp.relation.referenceHaroon NN, 2015, ARTHRITIS RES THER, V17, DOI 10.1186/s13075-015-0873-1-
hcfmusp.relation.referenceHaschka J, 2016, J CROHNS COLITIS, V10, P532, DOI 10.1093/ecco-jcc/jjw012-
hcfmusp.relation.referenceJEE WSS, 1990, BONE, V11, P253, DOI 10.1016/8756-3282(90)90078-D-
hcfmusp.relation.referenceKang KY, 2013, RHEUMATOLOGY, V52, P718, DOI 10.1093/rheumatology/kes364-
hcfmusp.relation.referenceKarberg K, 2005, J RHEUMATOL, V32, P1290-
hcfmusp.relation.referenceKhosla S, 2006, J BONE MINER RES, V21, P124, DOI 10.1359/JBMR.050916-
hcfmusp.relation.referenceKilic E, 2015, WORLD J ORTHOP, V6, P298, DOI 10.5312/wjo.v6.i2.298-
hcfmusp.relation.referenceKlingberg E, 2013, ARTHRITIS RES THER, V15, DOI 10.1186/ar4368-
hcfmusp.relation.referenceKlingberg E, 2012, J RHEUMATOL, V39, P1987, DOI 10.3899/jrheum.120316-
hcfmusp.relation.referenceKlingberg E, 2012, ARTHRITIS RES THER, V14, DOI 10.1186/ar3833-
hcfmusp.relation.referenceKocijan R, 2015, J BONE MINER RES, V30, P1775, DOI 10.1002/jbmr.2521-
hcfmusp.relation.referenceKocijan R, 2014, ANN RHEUM DIS, V73, P2022, DOI 10.1136/annrheumdis-2013-203791-
hcfmusp.relation.referenceKotake S, 1999, J CLIN INVEST, V103, P1345, DOI 10.1172/JCI5703-
hcfmusp.relation.referenceLange U, 2005, RHEUMATOL INT, V26, P115, DOI 10.1007/s00296-004-0515-4-
hcfmusp.relation.referenceMartin RB, 2002, BONE, V30, P8, DOI 10.1016/S8756-3282(01)00620-2-
hcfmusp.relation.referenceMeirelles ES, 1999, CLIN RHEUMATOL, V18, P364, DOI 10.1007/s100670050120-
hcfmusp.relation.referenceSchett G, 2010, NAT REV ENDOCRINOL, V6, P698, DOI 10.1038/nrendo.2010.190-
hcfmusp.relation.referenceSeeman E, 2006, NEW ENGL J MED, V354, P2250, DOI 10.1056/NEJMra053077-
hcfmusp.relation.referenceSimon D, 2017, J BONE MINER RES, V32, P722, DOI 10.1002/jbmr.3025-
hcfmusp.relation.referenceSINGH A, 1995, SOUTHERN MED J, V88, P939, DOI 10.1097/00007611-199509000-00010-
hcfmusp.relation.referenceSpeden DJ, 2002, J RHEUMATOL, V29, P516-
hcfmusp.relation.referenceStein EM, 2014, J BONE MINER RES, V29, P1101, DOI 10.1002/jbmr.2144-
hcfmusp.relation.referenceSutter S, 2014, J CLIN ENDOCR METAB, V99, P4231, DOI 10.1210/jc.2014-2177-
hcfmusp.relation.referenceSzulc P, 2011, J BONE MINER RES, V26, P1358, DOI 10.1002/jbmr.319-
hcfmusp.relation.referenceUluckan O, 2016, SCI TRANSL MED, V8, DOI 10.1126/scitranslmed.aad8996-
dc.description.indexMEDLINE-
dc.identifier.eissn1478-6362-
hcfmusp.citation.scopus15-
hcfmusp.scopus.lastupdate2022-06-16-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/Outros
Outros departamentos - FM/Outros


Files in This Item:
File Description SizeFormat 
art_NEUMANN_Cortical_bone_loss_is_an_early_feature_of_2018.PDFpublishedVersion (English)995.91 kBAdobe PDFThumbnail
View/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.