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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorROCHA, Lucila Soares da Silva
dc.contributor.authorRIECHELMANN, Rachel P.
dc.date.accessioned2018-11-21T17:09:07Z
dc.date.available2018-11-21T17:09:07Z
dc.date.issued2018
dc.identifier.citationCLINICS, v.73, suppl.1, article ID UNSP e542s, 7p, 2018
dc.identifier.issn1807-5932
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29631
dc.description.abstractPatients with unresectable metastatic colorectal cancer live for a median of three years when treated with standard therapies. While the evidence guiding cancer-directed treatment of this disease comes from phase III trials that have mostly enrolled patients with good performance status, some patients present with poor clinical conditions. The best treatment for these patients remains to be determined. We performed a systematic review of the treatment outcomes of patients with metastatic colorectal cancer and poor performance status, defined as Eastern Cooperative Oncology Group performance status >= 2. Eligible articles were prospective or retrospective studies or case reports published in English, Portuguese or Spanish. We searched PubMed, EMBASE, LILACS and the Cochrane Library from onset until October 2017 using specific keywords for each search. We found a total of 18 publications, mostly case reports and retrospective studies (14 articles). One was an uncontrolled prospective trial, two were observational studies and one was an individual patient meta-analysis. Although some studies suggested benefits in terms of symptomatic response with standard chemotherapy, with good safety profiles when dose-reduced regimens were administered, a true survival gain could not be demonstrated. The scientific evidence for treating metastatic colorectal cancer patients with poor performance status is scarce, and more studies evaluating treatment for this population are necessary since this condition is not uncommon in clinical practice, particularly in the public healthcare system and developing countries and among destitute populations.
dc.language.isoeng
dc.publisherHOSPITAL CLINICAS, UNIV SAO PAULO
dc.relation.ispartofClinics
dc.rightsopenAccess
dc.subjectMetastatic Colorectal Cancer
dc.subjectPoor Performance
dc.subjectChemotherapy
dc.subjectPerformance
dc.subjectSurvival
dc.subject.otherrandomized controlled-trial
dc.subject.otherelderly-patients
dc.subject.other1st-line treatment
dc.subject.otherpalliative chemotherapy
dc.subject.otherphase-3 trial
dc.subject.other2nd-line chemotherapy
dc.subject.otherclinical-trial
dc.subject.otheropen-label
dc.subject.otherbevacizumab
dc.subject.otherfluorouracil
dc.titleTreatment of patients with metastatic colorectal cancer and poor performance status: current evidence and challenges
dc.typearticle
dc.rights.holderCopyright HOSPITAL CLINICAS, UNIV SAO PAULO
dc.identifier.doi10.6061/clinics/2018/e542s
dc.identifier.pmid30281700
dc.subject.wosMedicine, General & Internal
dc.type.categoryreview
dc.type.versionpublishedVersion
hcfmusp.description.articlenumberUNSP e542s
hcfmusp.description.issuesuppl 1
hcfmusp.description.volume73
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000684065500024
hcfmusp.origem.id2-s2.0-85054460318
hcfmusp.origem.idSCIELO:S1807-59322018000200324
hcfmusp.publisher.citySAO PAULO
hcfmusp.publisher.countryBRAZIL
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dc.description.indexMEDLINE
dc.identifier.eissn1980-5322
hcfmusp.citation.scopus6
hcfmusp.scopus.lastupdate2022-06-16
Appears in Collections:

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - LIM/24
LIM/24 - Laboratório de Oncologia Experimental

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


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