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Title: Serological profile of John Cunningham virus (JCV) in patients with multiple sclerosis
Authors: BRANCO, Luciana PratsADONI, TorsoAPOSTOLOS-PEREIRA, Samira LuisaBROOKS, Joseph Bruno BidinCORREA, Eber CastroDAMASCENO, Carlos AugustoEBONI, Audred Cristina BiondoFEZER, LeticiaGAMA, Paulo Diniz daGONCALVES, Marcus Vinicius MagnoGOMES, SidneyGRZESIUK, Anderson KuntzMENDES, Maria FernandoMORALES, Rogerio RizoMUNIZ, AndrePAROLIN, Monica Fiuza KonckePIMENTEL, Maria Lucia VellutiniRIBEIRO, Mortise de CastroSANTOS, Gutemberg Augusto Cruz dosSATO, Henry KoitiSCHERPENHUIJZEN, Simone BatistaSCORCINE, ClaudioSIQUINELI, FabioSOUSA, Nise Alexandra de CarvalhoVARELA, Daniel LimaWINCKLER, Tereza Cristina AvilaFRAGOSO, Yara Dadalti
Citation: ARQUIVOS DE NEURO-PSIQUIATRIA, v.76, n.9, p.588-591, 2018
Abstract: Treatment options for multiple sclerosis (MS) have changed over the last few years, bringing about a new category of drugs with more efficient profiles. However, these drugs have come with a whole new profile of potential adverse events that neurologists have to learn well and quickly. One of the most feared complications of these MS treatments is progressive multifocal leukoencephalopathy caused by the reactivation of the John Cunningham virus (JCV). Objective: To identify the serologic profile of JCV in patients with MS. Methods: Data on serum antibodies for JCV were obtained using the enzyme-linked immunosorbent assay provided by the STRATIFY-JCV program. Results: A total of 1,501 blood tests were obtained from 1,102 patients with MS. There were 633 patients (57.1%) who were positive for antibodies for JCV and 469 patients who were negative (42.9%). Twenty-three patients became positive after initially having negative JCV antibody status. The rate of seroconversion was 18.5% over 22 months. Conclusion: The JCV serologic profile and seroconversion in Brazilian patients were similar to those described in other countries.
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/45
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica

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