Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/29675
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorANDRADE, Adriana R.-
dc.contributor.authorBARROS, Luisa L.-
dc.contributor.authorAZEVEDO, Matheus F. C.-
dc.contributor.authorCARLOS, Alexandre S.-
dc.contributor.authorDAMIAO, Aderson O. M. C.-
dc.contributor.authorSIPAHI, Aytan M.-
dc.contributor.authorLEITE, Andre Z. A.-
dc.date.accessioned2018-11-21T17:09:25Z-
dc.date.available2018-11-21T17:09:25Z-
dc.date.issued2018-
dc.identifier.citationCLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, v.9, article ID 142, 7p, 2018-
dc.identifier.issn2155-384X-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29675-
dc.description.abstractObjectives: Patients with inflammatory bowel disease have a higher risk of thrombosis, which is associated with a higher morbidity and mortality. Most data about VTE are related to hospitalized patients with active disease, but several cases happen in the outpatient setting, and are not covered by current prophylaxis recommendation. As the knowledge of VTE in outpatients is still poor, the aim of this study is to evaluate the risk, clinical data and mortality of thrombosis in patients followed in our center, comparing our findings with the current prophylaxis recommendation. Methods: The medical electronic chart of 1093 inflammatory bowel disease patients and their image exams were actively searched for words related to thrombosis, followed by charts reviewed to collect information about the event and data regarding clinical settings and thrombosis profile. Results: Overall, 654 Crohn's and 439 Colitis patients were included. Thrombosis prevalence was 5.1%, and mortality rate was higher in patients who had suffered thrombosis (10.71% vs. 1.45%, OR 8.0). Half of them developed thrombosis in the outpatient setting, 52% of these had disease activity, 17% had recent hospitalization, and 10% had previous thrombosis. In 27% of cases, diagnosis was done by routine image exams, with no clinical symptoms or previous history of thrombosis. None of them had used thromboprophylaxis. However, a great majority of patients who had thrombosis during hospitalization used heparin prophylaxis. Conclusion: Inflammatory bowel disease patients who develop thrombosis have an increased mortality risk. A significant proportion of the events happened in patients without a clear thromboprophylaxis recommendation or in those receiving heparin prophylaxis.-
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP) [2015/06196-0]-
dc.language.isoeng-
dc.publisherNATURE PUBLISHING GROUP-
dc.relation.ispartofClinical and Translational Gastroenterology-
dc.rightsopenAccess-
dc.subject.othervenous thromboembolism-
dc.subject.othercrohns-disease-
dc.subject.otherprevention-
dc.subject.othermanagement-
dc.subject.otherconsensus-
dc.titleRisk of thrombosis and mortality in inflammatory bowel disease-
dc.typearticle-
dc.rights.holderCopyright NATURE PUBLISHING GROUP-
dc.identifier.doi10.1038/s41424-018-0013-8-
dc.identifier.pmid29618721
dc.subject.wosGastroenterology & Hepatology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.description.articlenumber142-
hcfmusp.description.volume9-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000447528100001-
hcfmusp.origem.id2-s2.0-85045131913-
hcfmusp.publisher.cityNEW YORK-
hcfmusp.publisher.countryUSA-
hcfmusp.relation.referenceBollen L, 2016, EUR J GASTROEN HEPAT, V28, P1, DOI 10.1097/MEG.0000000000000495-
hcfmusp.relation.referenceDi Fabio F, 2011, SEMIN THROMB HEMOST, V37, P220, DOI 10.1055/s-0031-1273086-
hcfmusp.relation.referenceFumery M, 2014, J CROHNS COLITIS, V8, P469, DOI 10.1016/j.crohns.2013.09.021-
hcfmusp.relation.referenceGionchetti P, 2017, J CROHNS COLITIS, V11, P135, DOI 10.1093/ecco-jcc/jjw169-
hcfmusp.relation.referenceGrainge MJ, 2010, LANCET, V375, P657, DOI 10.1016/S0140-6736(09)61963-2-
hcfmusp.relation.referenceHeit JA, 2006, J THROMB THROMBOLYS, V21, P23, DOI 10.1007/s11239-006-5572-y-
hcfmusp.relation.referenceHigaki S, 2006, J GASTROEN HEPATOL, V21, P1407, DOI 10.1111/j.1440-1746.2006.04319.x-
hcfmusp.relation.referenceIrving PM, 2005, CLIN GASTROENTEROL H, V3, P617, DOI 10.1053/S1542-3565(05)00154-0-
hcfmusp.relation.referenceKohoutova D, 2015, J THROMB THROMBOLYS, V39, P489, DOI 10.1007/s11239-014-1129-7-
hcfmusp.relation.referenceLaMori JC, 2015, CLIN THER, V37, P62, DOI 10.1016/j.clinthera.2014.10.024-
hcfmusp.relation.referenceNguyen GC, 2008, AM J GASTROENTEROL, V103, P2272, DOI 10.1111/j.1572-0241.2008.02052.x-
hcfmusp.relation.referenceNguyen GC, 2014, GASTROENTEROLOGY, V146, P835, DOI 10.1053/j.gastro.2014.01.042-
hcfmusp.relation.referenceNovacek G, 2010, GASTROENTEROLOGY, V139, P779, DOI 10.1053/j.gastro.2010.05.026-
hcfmusp.relation.referenceSam JJ, 2013, DIGEST DIS SCI, V58, P46, DOI 10.1007/s10620-012-2435-6-
hcfmusp.relation.referenceScoville EA, 2014, INFLAMM BOWEL DIS, V20, P631, DOI 10.1097/MIB.0000000000000007-
hcfmusp.relation.referenceYusuf Hussain R., 2012, Morbidity and Mortality Weekly Report, V61, P401-
dc.description.indexPubMed-
hcfmusp.citation.scopus46-
hcfmusp.scopus.lastupdate2024-02-23-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/07
LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


Files in This Item:
File Description SizeFormat 
art_ANDRADE_Risk_of_thrombosis_and_mortality_in_inflammatory_bowel_2018.PDFpublishedVersion (English)546.97 kBAdobe PDFThumbnail
View/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.